- Incorporating Pendent Fullerenes with High Refractive Index Backbones: A Conjunction Effect Method for High Refractive Index Polymers
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To achieve high refractive index polymers (HRIPs), we report here the design and synthesis of four fullerene polyesters (P1-P4), based on the conjunction effect from the high refractive index polyester backbones and pendent fullerene side chains. At sodiu
- Chen, Shuang,Chen, Dongxue,Lu, Min,Zhang, Xin,Li, He,Zhang, Xiaoyan,Yang, Xiaoming,Li, Xiaohong,Tu, Yingfeng,Li, Christopher Y.
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- C-I···π Halogen Bonding Driven Supramolecular Helix of Bilateral N-Amidothioureas Bearing β-Turns
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We report the first example of C-I···π halogen bonding driven supramolecular helix in highly dilute solution of micromolar concentration, using alanine based bilateral I-substituted N-amidothioureas that contain helical fragments, the β-turn structures. T
- Cao, Jinlian,Yan, Xiaosheng,He, Wenbin,Li, Xiaorui,Li, Zhao,Mo, Yirong,Liu, Maili,Jiang, Yun-Bao
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- Synthesis, thermal, and photocrosslinking studies of thermotropic liquid crystalline poly(benzylidene-ether)esters containing α,β-unsaturated ketone moiety in the main chain
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A series of poly(benzylidene-ether)esters containing a photoreactive benzylidene chromophore in the main chain were synthesized from 2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMBCH) with various aliphatic and aromatic diacid chlorides by an interfacial polycondensation technique. The intrinsic viscosity of the synthesized homo and copolymers determined by Ubbelohde viscometer was found to be 0.12 to 0.17 dL/g. The molecular structure of the monomer and polymers was confirmed by FT-IR, 1H NMR, and 13C NMR spectral analyses. These polymers were studied for their thermal stability and photochemical properties. Thermal properties were evaluated by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). It was found that the polymers were stable up to 280 °C and start degrading thereafter. Increase in acid methylene spacer length decreased the thermal stability. The self-extinguishing property of the synthesized polymers was studied by calculating the limiting oxygen index (LOI) value using a Van Krevelen's equation. The influence of the length of methylene spacer on phase transition was investigated using DSC and odd-even effect has been observed. Hot-stage optical polarizing microscopic (HOPM) study showed that most of the polymers exhibited birefringence and opalescence properties. The photolysis of liquid crystalline poly(benzylidene-ether)esters revealed that α,β-unsaturated ketone moiety in the main chain dimerises through 2π + 2π cycloaddition reaction to form a cyclobutane derivative and leads to crosslinking.
- Muthusamy, Athianna,Balaji, Krishnasamy,Murugavel, Salem Chandrasekaran
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- Exploiting Peptidomimetics to Synthesize Compounds That Activate Ryanodine Receptor Calcium Release Channels
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Ryanodine receptor (RyR) Ca2+-release channels are essential for contraction in skeletal and cardiac muscle and are prime targets for modification of contraction in disorders that affect either the skeletal or heart musculature. We designed and synthesized a number of compounds with structures based on a naturally occurring peptide (A peptides) that modifies the activity of RyRs. In total, 34 compounds belonging to eight different classes were prepared. The compounds were screened for their ability to enhance Ca2+ release from isolated cardiac sarcoplasmic reticulum (SR) vesicles, with 25 displaying enhanced Ca2+ release. Competition studies with the parent peptides indicated that the synthetic compounds act at a competing site. The activity of the most effective of the compounds, BIT 180, was further explored using Ca2+ release from skeletal SR vesicles and contraction in intact skeletal muscle fibers. The compounds did not alter tension in intact fibers, indicating that (as expected) they are not membrane permeable, but importantly, that they are not toxic to the intact cells. Proof in principal that the compounds would be effective in intact muscle fibers if rendered membrane permeable was obtained with a structurally related membrane-permeable scorpion toxin (imperatoxin A), which was found to enhance contraction.
- Robinson, Ken,Easton, Christopher J.,Dulhunty, Angela F.,Casarotto, Marco G.
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- Infrared and Raman spectra of terephthalonitrile and terephthalonitrile-15N2. Force field for out-of-plane vibrations
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A general assignment of the vibrational spectra of terephthalonitrile and terephthalonitrile-15N2 is proposed on the basis of their infrared and Raman spectra.The relevant symmetry is found to be D2h.The force field for the out-of-plane vibrati
- Arenas, J. F.,Marcos, J. I.,Ramirez, F. J.
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- Phosphazenium chloride catalysts immobilized on SBA-15 mesoporous material and silica gel: New exceptionally active catalysts for the chlorination of organic acids
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Novel reusable phosphazenium chloride catalysts immobilized on SBA-15 mesoporous material and silica gel show exceptional activities and selectivities even in the continuous chlorination reaction of organic acids with thionyl chloride or phosgene.
- Kim, Keun-Sik,Kim, Jong-Ho,Seo, Gon
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- Effect of regioisomerism on the self-assembly and photophysical behavior of 1,3,4-thiadiazole-based polycatenars
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A new class of polycatenars, where the central benzene ring is connected to two arms derived from substituted 1,3,4-thiadiazoles at the 1,3- and 1,4-positions, was synthesized and characterized. These thiadiazole-based molecules are promising as they stabilize columnar phases over a wide temperature range, in comparison to their oxadiazole analogues. The para-substituted polycatenars exhibited a columnar hexagonal and/or a columnar oblique phase, while the meta-substituted polycatenars exhibited solely a columnar oblique phase. The para-substituted polycatenars exhibited green emission, while the meta-substituted polycatenars exhibited blue emission in solution and film states. Stabilization of a broad range columnar phase and luminescence in the solid state make these new compounds promising from the viewpoint of applications in emissive displays. The self-assembly and luminescence of these regioisomers was greatly influenced by the molecular structure.
- Pathak, Suraj Kumar,Nath, Subrata,Gupta, Ravindra Kumar,Rao, D. S. Shankar,Prasad, S. Krishna,Achalkumar, Ammathnadu S.
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- Aromatic Esters, Carbinols, and Derivatives Thereof with Perfluorohexyl Residues as Alternatives to Perfluoroalkanecarboxylic and -sulfonic Acids
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Four perfluorohexyl carbinols have been prepared from the corresponding Grignard reagent and benzaldehyde, terephthalaldehyde, isophthalaldehyde, and trimesaldehyde. The corresponding secondary alcohols were then transformed by alkylation and acylation reactions to form a total of 14 ethers (methyl, ethyl, propyl, and n-hexyl ethers) and esters (acetyl and 2-ethylhexanoyl), respectively. Furthermore, 11 perfluoroalkyl carboxylates were prepared from aromatic, heteroaromatic, and aliphatic mono-, di-, tri-, and tetracarboxylic acids and tridecafluorooctanol. The wettability of all 29 materials was investigated by the water contact angle measurements of thin films on glass surfaces. In up to six cases, contact angles greater than 130° were observed, which indicates that the products might be suitable candidates for the impregnation of surfaces. With their relatively short perfluoroalkyl side-chains and therefore low bioaccumulativity, the target compounds might be beneficial alternatives to established products.
- Alpers, Torben,Muesmann, Thomas W. T.,Temme, Oliver,Christoffers, Jens
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- Photo-on-Demand Synthesis of Vilsmeier Reagents with Chloroform and Their Applications to One-Pot Organic Syntheses
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The Vilsmeier reagent (VR), first reported a century ago, is a versatile reagent in a variety of organic reactions. It is used extensively in formylation reactions. However, the synthesis of VR generally requires highly toxic and corrosive reagents such as POCl3, SOCl2, or COCl2. In this study, we found that VR is readily obtained from a CHCl3 solution containing N,N-dimethylformamide or N,N-dimethylacetamide upon photo-irradiation under O2 bubbling. The corresponding Vilsmeier reagents were obtained in high yields with the generation of gaseous HCl and CO2 as byproducts to allow their isolations as crystalline solid products amenable to analysis by X-ray crystallography. With the advantage of using CHCl3, which bifunctionally serves as a reactant and a solvent, this photo-on-demand VR synthesis is available for one-pot syntheses of aldehydes, acid chlorides, formates, ketones, esters, and amides.
- Liang, Fengying,Eda, Kazuo,Okazoe, Takashi,Wada, Akihiro,Mori, Nobuaki,Konishi, Katsuhiko,Tsuda, Akihiko
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- Synthesis of poly β ketoesters via double acylketene trapping
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The synthesis and characterization of polymeric β ketoesters is herein reported. These polymers were prepared by allowing highly electrophilic acylketenes, generated in situ via thermolysis of stable 6-substituted-2,2-dimethyl-4H-1,3-dioxin-4-ones, to rea
- Palma, Aniello,Serginson, James M.,Barrett, Anthony G.M.
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- Synthesis and characteriation of novel poly (ester amide)s containing benzthiazole heterocyclic ring
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The novel Poly (ester-amide)s (PEAs) were prepared by inrter-facial polycondensation of 5 - hydroxy - 2 - amino benzthiazole with various di-basic acid chlorides. The PEAs were characterized by elements analysis, IR spectra studies, Mn estimated by non aqueous conductometric titration and thermogravimetry. The electric conductivity of all the poly (ester amide)s PEAs was also measured at room temperature and it was found that the PEAs have semiconducting properties.
- Patel,Desai,Patel
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- Primary coloured electrochromism of aromatic oxygen and sulfur diesters
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Eleven aromatic diesters and thioic S,S′-diesters were synthesized and investigated using electrochemical (cyclic voltammetry and controlled potential electrolysis) and UV-vis spectroscopic techniques over a range of temperatures. Nine of the compounds exhibited vibrant colour changes from a colourless state in their neutral forms to brightly coloured upon one-electron electrochemical reduction in acetonitrile. The compounds were found to display either red, green or blue colours in their one-electron reduced states. The electrochromic properties of 3 of the compounds that displayed the most vibrant colour changes were examined in solution using a gold micro-mesh electrode laminated inside a polymer film.
- Xu, Xiuhui,Webster, Richard D.
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- Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist
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NF449 [4,4′,4″,4′′′-(carbonylbis(imino-5,1,3- benzenetriyl-bis(carbonylimino)))tetrakisbenzene-1,3-disulfonic acid-octasodiumsalt)] was recently described to inhibit recombinant rP2X 1 receptors (Naunyn Schmiedeberg's Arch. Pharmacol. 364 (2001
- Kassack, Matthias U.,Braun, Kirsten,Ganso, Matthias,Ullmann, Heiko,Nickel, Peter,Boeing, Barbara,Mueller, Gregor,Lambrecht, Guenter
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- Novel bivalent securinine mimetics as topoisomerase I inhibitors
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A series of novel bivalent securinine mimetics incorporating different linkers between C-15 and C-15′ were synthesized and their topoisomerase I (Topo I) inhibitory activities evaluated. It was thus revealed that mimetic R2 incorporating a rigid m-substituted benzene linker exhibits Topo I inhibitory activity three times that of parent securinine. Comprehensive structure-activity relationship analyses in combination with docking studies were used to rationalize the potent activity of these bivalent mimetics. Mechanistic studies served to confirm the deductions arising from docking studies that the active bivalent mimetics not only inhibited complexation between Topo I and DNA but also stabilized the Topo I-DNA complex itself.
- Hou, Wen,Lin, Hui,Wang, Zhen-Ya,Banwell, Martin G.,Zeng, Ting,Sun, Ping-Hua,Lin, Jing,Chen, Wei-Min
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- Photolysis of p-Phenylbis(chlorodiazirine), Studied by Matrix Isolation Spectroscopy. Generation, Detection and Characterization of p-Phenylenebis(chloromethylene)
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Photolysis of the title bis-diazirine matrix-isolated in Ar at 10 K monitored by IR and UV/vis spectroscopy indicated that the diazirine underwent stepwise elimination of N2 to produce 3-(4-chlorocarbenophenyl)-3-chlorodiazirine which then eliminated the
- Tomioka, Hideo,Komatsu, Kazunori,Nakayama, Takehito,Shimizu, Masayoshi
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- Br?nsted acid-catalyzed chlorination of aromatic carboxylic acids
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The chlorination of aromatic carboxylic acids with SOCl2 has been effectively performed by reacting with a Br?nsted acid as the catalyst. Based on this discovery, an efficient catalytic method that is cheaper than traditional catalytic methods was developed. 20 substrates were chlorinated offering excellent yields in a short reaction time. And the SOCl2/Br?nsted acid system has been used in a larger scale preparative reaction. A dual activation mechanism was proposed to prove the irreplaceable system of SOCl2/Br?nsted acid.
- Yu, Zhiqun,Yao, Hongmiao,Xu, Qilin,Liu, Jiming,Le, Xingmao,Ren, Minna
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supporting information
p. 685 - 689
(2021/04/09)
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- Preparation method of terephthaloyl chloride
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The invention discloses a preparation method of terephthaloyl chloride, and belongs to the technical field of organic chemical synthesis. To 85 - 110 °C reaction 5 - 10h, after the reaction is finished, the reaction mixture is separated from the catalyst,
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Paragraph 0028; 0030-0041
(2021/10/27)
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- BENZENE 1,4-BIS(BISPHOSPHONIC ACID)-BASED METAL COMPLEXES, METHOD OF SYNTHESIS AND APPLICATIONS THEREOF
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The invention provides extended bisphosphonate-based metal complexes using benzene1,4-bis(bisphosphonic acid) (BBPA), an analog of benzene 1,4-dicarboxylic acid (BDC). Hydrothermal synthesis of BBPA with the bioactive metals Ca2+, Zn2+/su
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Paragraph 0103; 0104
(2021/10/15)
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- One-step Conversion of Amides and Esters to Acid Chlorides with PCl3
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A general and efficient iodine-promoted chlorination of amides and esters with phosphorus trichloride is described. For the first time. Various inactivated amides including secondary and tertiary amides were directly converted to the corresponding acid chlorides in one-step. The substrate scope of methyl esters including aromatic and aliphatic esters was also explored under this system. This method is simple, scalable and wide in scope, which provides an approach to preparation of these acid chlorides.
- Li, Fangshao,Wu, Xiaofang,Guo, Fengzhe,Tang, Zi-Long,Xiao, Jing
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p. 4314 - 4317
(2021/07/16)
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- Process for preparing paraphthaloyl chloride
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The invention relates to a new process for preparing paraphthaloyl chloride. The process comprises the following steps: reacting terephthalic acid with methyltrichlorosilane at 40-77 DEG C for 6-12 hours by using carbon tetrachloride as a solvent and Lewi
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Paragraph 0032-0033; 0034-0035; 0036-0037; 0038-0041
(2020/11/12)
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- Amide pyrazole compound and preparation method and application thereof
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The invention provides an amide pyrazole compound and a preparation method and application thereof. The amide pyrazole compound has a structure as shown in a formula I or II, and R is 5-pyrazolyl or 4-pyrazolyl. An amide structure is combined with pyrazole ligands, a series of amide pyrazole compounds are obtained by designing different coordination angles, coordination numbers and the like, and the amide pyrazole compound has the advantages of rich coordination forms, diversified functions, outstanding performance and the like, and can be applied to the fields of coordination chemistry, organic chemistry, inorganic chemistry, biochemistry, biopharmacy and the like. The preparation method has the advantages of few synthesis steps, simple operation and low production cost, and the yield is75% or above so that the preparation method is suitable for industrial production.
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Paragraph 0032-0038
(2020/09/09)
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- Framework molecules based on folding and assembling of cyclic polymers and preparation method thereof
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The invention discloses framework molecules based on folding and assembling of cyclic polymers and a preparation method thereof. The framework molecules have a chemical name of cyclic polyesters whichcomprise cyclic di-polyester namely 1-Ar, cyclic tri-po
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Paragraph 0053-0055
(2019/05/15)
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- Preparation process for terephthaloyl chloride
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The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation process for terephthaloyl chloride. Under the irradiation of a LED light source, an excesschlorine gas is introduced into a p-xylene to obtain crude product of 1.4-2 (trichloromethyl) benzene, excess chlorine gas is absorbed by alkali liquor; the obtained crude product of 1,4-2 (trichloromethyl) benzene and a terephthalic acid react under the action of a catalyst, adopt nitrogen to drive out the hydrogen chloride gas produced by the reaction until no hydrogen chloride gas is released,and a crude product of the terephthaloyl chloride is obtained; decolorizing agent is added to the crude product of terephthaloyl chloride, and the terephthaloyl chloride is obtained by rectification under vacuum. The preparation process has the advantages of simple process, easy-to-get raw materials, low cost, convenient operation, high product quality, stable quality and the like.
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Paragraph 0023; 0025-0027; 0029-0031; 0033-0034
(2019/01/23)
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- AMIDE-BASED HOLE-TRANSPORTING OR HOLE-INJECTING MATERIALS
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The present invention provides a hole-transporting or hole-injecting material for an optoelectronic device, comprising a compound of the formula (I) and/or a compound of the formula (II), (I) (II) wherein: Ar1 and Ar2 independently represent an optionally substituted arylene group, an optionally substituted heteroarylene group or an optionally substituted fluorenylene group; R1 and R2 independently represent hydrogen or a group -NAr6Ar7, wherein Ar6 and Ar7 are independently an optionally substituted aryl group, an optionally substituted heteroaryl group, or an optionally substituted fluorenylene group, and wherein a direct covalent bond may be present between Ar6 and Ar7 such that a fused heterocyclic ring system is formed which contains Ar6, Ar7 and the nitrogen atom to which they are attached; L1 and L3 independently represent a bond, an optionally substituted arylene group, an optionally substituted fluorenylene group, or an optionally substituted heteroarylene group; and L2 represents a bond, an optionally substituted arylene group, an optionally substituted heteroarylene group, an optionally substituted fluorenylene group, or a group - Ar3-N(Ar4)-Ar5-, wherein Ar3 and Ar5 represent optionally substituted arylene groups, and Ar4 represents an optionally substituted aryl group.
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Page/Page column 23-24
(2018/03/01)
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- Synthesis and characterization of ferrocenyl esters: Their anti-oxidant activity and DNA-binding ability
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In continuation to our work on biologically active material, some new ferrocenyl esters were prepared by condensation of 4-ferrocenyl phenol (ROH) with ferrocenyl dicarboxylic acid chlorides (DCC) at low temperature. The synthesized compounds (E1-E9) were characterized by analyzing their physical properties, FT-IR, 1H-NMR, UV-visible spectroscopic and cyclic voltammetric studies. The DPPH free radical scavenging assay was performed to explore their potential as antioxidant which showed that the E1 had maximum scavenging ability (77.11%) whereas E3 showed minimum (52%) compared with the standard. Cyclic voltammetric studies indicated that these compounds were electroactive in potential window of 2.0-0.0V. Binding mode found in these esters was an electrostatic interaction which is considered as strongest amongst all. Therefore, these compounds are considered to have DNA-binding capability and are potential DNA binders.
- Bukhari, Syeda Anam,Gul, Asghari,Akhter, Zareen,Bashir, Amna
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p. 375 - 382
(2018/06/06)
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- METHOD OF PREPARING p-PHENYLENEDIAMINE
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Provided is a method for producing paraphenylenediamine. More specifically, the present invention relates to a method for producing paraphenylenediamine, comprising the following steps: carrying out a chlorination reaction using a by-product from a production process of dimethyl terephthalate; preparing terephthalamide through an amidation reaction using the chlorinated product; and carrying out Hofmann rearrangement from the terephthalamide.COPYRIGHT KIPO 2018
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Paragraph 0088-0089; 0096
(2018/07/03)
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- Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
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Current methods for functional group interconversion have, for the most part, relied on relatively strong driving forces which often require highly reactive reagents to generate irreversibly a desired product in high yield and selectivity. These approaches generally prevent the use of the same catalytic strategy to perform the reverse reaction. Here we describe a catalytic functional group metathesis approach to interconvert, under CO-free conditions, two synthetically important classes of electrophiles that are often employed in the preparation of pharmaceuticals and agrochemicals—aroyl chlorides (ArCOCl) and aryl iodides (ArI). Our reaction design relies on the implementation of a key reversible ligand C–P bond cleavage event, which enables a non-innocent, metathesis-active phosphine ligand to mediate a rapid aryl group transfer between the two different electrophiles. Beyond enabling a practical and safer approach to the interconversion of ArCOCl and ArI, this type of ligand non-innocence provides a blueprint for the development of a broad range of functional group metathesis reactions employing synthetically relevant aryl electrophiles.
- Lee, Yong Ho,Morandi, Bill
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p. 1016 - 1022
(2018/09/06)
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- Method of co-producing methyl benzoic acid, methylbenzoyl chloride and phthaloyl dichloride
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The invention discloses a method of co-producing methyl benzoic acid, methylbenzoyl chloride and phthaloyl dichloride. The method comprises the following steps: (1) continuously introducing xylene, acatalyst and oxygen-containing gas into an oxidizing reactor to react to obtain an oxidized reaction solution; (2) rectifying and separating the oxidized reaction solution to obtain a low-boiling-point component and an initial evaporative tower bottom; (3) rectifying the initial evaporative tower bottom to obtain a methyl benzoic acid product and a tower bottom; (4) carrying out an acylating chlorination reaction on the tower bottom and an acylating chlorination reagent to obtain an acyl chloride reaction solution; and (5) rectifying and separating the acyl chloride reaction solution to separately obtain methylbenzoyl chloride and phthaloyl dichloride products. The method provided by the invention has the advantages of being simple in process, small in equipment investment, green and environment-friendly and good in comprehensive economical benefit.
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Paragraph 15-17; 27; 28
(2018/06/16)
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- Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction
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Identification of novel Hsp90 inhibitors to disrupt Hsp90-Cdc37 protein-protein interaction (PPI) could be an alternative strategy to achieve Hsp90 inhibition. In this paper, a series of small molecules targeting Hsp90-Cdc37 complex are addressed and characterized. The molecules' key characters are determined by utilizing a structure-based virtual screening workflow, derivatives synthesis, and biological evaluation. Structural optimization and structure–activity relationship (SAR) analysis were then carried out on the virtual hit of VS-8 with potent activity, which resulted in the discovery of compound 10 as a more potent regulator of Hsp90-Cdc37 interaction with a promising inhibitory effect (IC50?=?27?μM), a moderate binding capacity (KD?=?40?μM) and a preferable antiproliferative activity against several cancer lines including MCF-7, SKBR3 and A549?cell lines (IC50?=?26?μM, 15?μM and 38?μM respectively). All the data suggest that compound 10 exhibits moderate inhibitory effect on Hsp90-Cdc37 and could be regard as a first evidence of a non-natural compound targeting Hsp90-Cdc37 PPI.
- Wang, Lei,Li, Li,Zhou, Zi-Han,Jiang, Zheng-Yu,You, Qi-Dong,Xu, Xiao-Li
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- From Surprising Solvothermal Reaction to Uncommon Zinc(II)-Catalyzed Aromatic C-H Activation Reaction for Direct Nitroquinoline Synthesis
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In this work, we first found a surprising solvothermal reaction for direct dinitration of quinoline derivative. To explore the application in direct nitroquinoline synthesis, this reaction was subsequently modified as an equivalent reaction in a Schlenk tube. More significantly, after a constant attempt, nitrated derivative was obtained in optimized condition with a zinc(II) sulfate catalyst, where some substrates with strong electron-withdrawing group were first nitrated by a directly catalyzed condition. This new zinc(II)-catalyzed aromatic C-H activation reaction is the first example of direct dinitration by a single catalyst, which will be a new facile and environmentally friendly strategy to access synthetically useful nitroquinoline derivative.
- Wang, Yazhen,Yu, Feihu,Han, Xiao,Li, Ming,Tong, Yue,Ding, Jie,Hou, Hongwei
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supporting information
p. 5953 - 5958
(2017/05/22)
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- Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli
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In Gram-negative bacteria, efflux pumps are able to prevent effective cellular concentrations from being achieved for a number of antibiotics. Small molecule adjuvants that act as efflux pump inhibitors (EPIs) have the potential to reinvigorate existing antibiotics that are currently ineffective due to efflux mechanisms. Through a combination of rigorous experimental screening and in silico virtual screening, we recently identified novel classes of EPIs that interact with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Escherichia coli. Herein, we present initial optimization efforts and structure-activity relationships around one of those previously described hits, NSC 60339 (1). From these efforts we identified two compounds, SLUPP-225 (17h) and SLUPP-417 (17o), which demonstrate favorable properties as potential EPIs in E. coli cells including the ability to penetrate the outer membrane, improved inhibition of efflux relative to 1, and potentiation of the activity of novobiocin and erythromycin.
- Haynes, Keith M.,Abdali, Narges,Jhawar, Varsha,Zgurskaya, Helen I.,Parks, Jerry M.,Green, Adam T.,Baudry, Jerome,Rybenkov, Valentin V.,Smith, Jeremy C.,Walker, John K.
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p. 6205 - 6219
(2017/08/02)
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- Bispyrimidine diamine and preparation method thereof
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The invention discloses bispyrimidine diamine and a preparation method thereof. According to the preparation method, the bispyrimidine diamine is prepared through a five-step reaction by taking nitrobenzonitrile as a raw material. The bispyrimidine diamine disclosed by the invention can also be used as a raw material for synthesising high-performance polymers, such as polyimide and polyamide, and has a wide application prospect in the aspect of high-performance fibres.
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Paragraph 0070; 0073
(2017/08/29)
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- CLEAN PROCESS FOR PREPARING CHLOROFORMYL-SUBSTITUTED BENZENE
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Clean process for preparing a chloroformyl-substituted benzene by oxidation of a tail gas hydrogen chloride from a chlorination reaction and a chloroacylation reaction and recycling of the resulting oxidation product chlorine gas into the chlorination reaction. The present invention provides a clean process for preparing a polymer-grade chloroformyl-substituted benzene.
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Paragraph 0126; 0140
(2017/12/17)
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- A second (trichloromethyl) benzene and two (chloroformyl) benzenetrisamide preparation method
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The present invention relates to a method for preparing bis(trichloromethyl)benzene through a photochemical reaction and preparing bis(chloroformyl)benzene through the further reaction of the bis(trichloromethyl)benzene. According to the present invention, di(methyl)benzene is added to a reactor, chlorine gas is introduced under the control of the illuminance of an incident light source and the reaction temperature, the obtained reaction mixture is subjected to a simple treatment so as to obtain the high purity bis(trichloromethyl)benzene; with the bis(trichloromethyl)benzene of the present invention, the high purity bis(chloroformyl)benzene, one of the aramid fiber production raw materials, can be conveniently obtained; and the preparation method of the present invention has the following advantages that the solvent, the free radical initiator, the photosensitizer and other third components can not be inproduced, and only the stage-control of the reaction condition and the wavelength and the intensity of the light source are required so as to improve the product purity.
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Paragraph 0114; 0115
(2017/02/24)
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- A kind of preparation method of phthayl chloride
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The invention relates to a method for preparing paraphthaloyl chloride. The method comprises the following steps: mixing thionyl chloride and terephthalic acid according to the mass ratio of 2:1 to 5:1; adding one or more of nitrogen-containing organic ba
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Paragraph 0018; 0019; 0020-0032
(2017/02/09)
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- METHOD FOR THE PREPARATION OF TRICHLOROMETHYL-GROUP-SUBSTITUTED BENZENE
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The present application relates to a method for photochlorination, and specifically to photochlorination by a photochemical reaction of an aromatic compound with gaseous chlorine so as to prepare a trichloromethyl-substituted benzene, and to a method using bis-(trichloromethyl)-benzene as the trichloromethyl-substituted benzene to prepare by further reaction bis-(chloroformyl)-benzene. Through the control of temperature, illuminance and consumption of gaseous chlorine, the method of this application can greatly improve the purity of trichloromethyl-substituted benzene and further prepare polymer-grade bis-(chloroformyl)-benzene with low cost. The present application also relates to a method for purifying trichloromethyl-substituted benzene, and specifically to a method for purifying trichloromethyl-substituted benzene via molecular distillation. The present application further relates to a photochlorination reactor for use in photochlorination reactions (such as those of the present application).
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Paragraph 0146
(2016/06/28)
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- Preparation method of p-phthaloyl chloride
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The invention belongs to the technical field of chemical synthesis, and in particular relates to a preparation method of p-phthaloyl chloride. The preparation method comprises the steps that terephthalic acid, a catalyst and thionyl chloride are added int
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Paragraph 0018; 0019; 0020
(2016/10/08)
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- Recover method of thionyl chloride in continuous preparation process of p-phthaloyl chloride
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The invention belongs to the technical field of chemical synthesis, and in particular relates to a recover method of thionyl chloride in a continuous preparation process of p-phthaloyl chloride. The recover method comprises the steps that terephthalic aci
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Paragraph 0024; 0025
(2016/10/08)
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- Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality
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1:1 and 2:2 oligomeric piperazinophanes with an intraannular ester functionality have been synthesized via Mannich reaction of various aromatic esters with piperazine by a one-pot reaction under benign conditions through the multicomponent reaction methodology. The newly synthesized piperazinophanes were characterized using spectral and analytical methods. The ester based 1:1 oligomeric piperazinophanes exhibit good target binding ability in molecular docking studies and also show better antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Streptococcus pyogenes bacteria than the 2:2 oligomeric piperazinophanes.
- Selvarani, Sivasamy,Rajakumar, Perumal
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p. 9494 - 9499
(2016/11/11)
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- Paraphthaloyl chloride's apparatus for producing
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The utility model belongs to the technical field of chemical synthesis, concretely relates to paraphthaloyl chloride's apparatus for producing, including a tubular reactor, a tubular reactor, first condenser, a vapour and liquid separator, the 2nd tubular
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Paragraph 0014
(2016/11/28)
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- Blue light-emitting polyamide and poly(amide-imide)s containing 1,3,4-oxadiazole ring in the side chain
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A new diamine monomer containing a 1,3,4-oxadiazole ring, 4,4′-diamino-4″-[2-(4-phenoxy)-5-(4-dimethylaminophenyl)-1,3,4-oxadiazole]triphenylmethane, was synthesized and characterized. The diamine is used to prepare novel polyamide and poly(amide-imide)s
- Hamciuc, Corneliu,Hamciuc, Elena,Homocianu, Mihaela,Nicolescu, Alina,Carja, Ionela-Daniela
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p. 110 - 113
(2015/03/31)
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- Synthesis and two-photon absorption property of new π -conjugated donor-acceptor polymers carrying different heteroaromatics
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In this communication, we report the synthesis of three newly designed fluorescent polymers P1-P3, starting from simple thiophene derivatives through precursor polyhydrazide route. The new polymers, carrying donor and acceptor heterocyclic moieties with different spacer groups were found to be thermally stable and good of nonlinear optical (NLO) materials with two photon absorption property. The structures of newly synthesized monomers and polymers were confirmed by FTIR, NMR spectral and elemental analyses. Further, polymers were characterized by GPC and TGA studies. Their linear optical and electrochemical properties were evaluated by UV-vis, fluorescence spectroscopic and cyclic voltammetric (CV) studies, respectively, whereas their NLO properties were studied by Z-scan technique using Nd: YAG laser at 532 nm with 7 ns pulse. The electrochemical band gap of P1-P3 was determined to be 1.98, 1.91 and 2.05 eV, respectively. The NLO results reveal that polymers P1-P3 show good optical limiting property with TPA coefficient values 2.9 × 10 - 11 m/W, 8.0 × 10 - 11 m/W and 1.4 × 10 - 11 m/W, respectively.
- Sunitha,Vishnumurthy,Adhikari
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- Preparation and characterization of organic-functionalized mesoporous silica as heavy metal adsorbents
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Novel organic-inorganic hybrid mesoporous materials have attracted much attention because the functional organic groups can bring these materials special properties, such as selective absorption and new catalytic properties. In this paper, two kind of bis
- Zhao, Hongli,Hong, Tao,Lan, Minbo,Wang, Wenjuan,Zheng, Saijing,Liu, Baizhan
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p. 1295 - 1299
(2013/05/22)
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- SAR based design of nicotinamides as a novel class of androgen receptor antagonists for prostate cancer
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Molecular knowledge of pure antagonism and systematic SAR study offered a direction for structural optimization of DIMN to provide nicotinamides as a novel series of AR antagonists. Nicotinamides with extended linear scaffold bearing sterically bulky alkoxy groups on isoquinoline end were synthesized for H12 displacement. AR binding affinity and molecular basis of antiandrogenic effect establish the optimized derivatives, 7au and 7bb, as promising candidates of second generation AR antagonists for advanced prostate cancer.
- Yang, Su Hui,Song, Chin-Hee,Van, Hue Thi My,Park, Eunsook,Khadka, Daulat Bikram,Gong, Eun-Yeung,Lee, Keesook,Cho, Won-Jea
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supporting information
p. 3414 - 3418
(2013/06/05)
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- Effect of conformational parameters on physical properties of polymers containing pendant phenoxyphthalonitrile substituents
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Heteroaromatic polymers are considered to be high performance organic materials due to their unique and highly attractive properties, including outstanding thermal and mechanical resistance, that arise from their aromatic structure and strong interactions
- Carja, Ionela-Daniela,Hamciuc, Corneliu,Vlad-Bubulac, Tachita,Bruma, Maria,Ronova, Inga A.
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p. 1693 - 1703
(2013/10/22)
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- A palladium-catalyzed carbonylation approach to acid chloride synthesis
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We describe a new approach to acid chloride synthesis via the palladium-catalyzed carbonylation of aryl iodides. The combination of sterically encumbered phosphines (PtBu3) and CO coordination has been found to facilitate the rapid carbonylation of aryl iodides into acid chlorides via reductive elimination from (tBu3P)(CO) Pd(COAr)Cl. The formation of acid chlorides can also be exploited to perform traditional aminocarbonylation reactions under exceptionally mild conditions (ambient temperature and pressure), and with a range of weakly nucleophilic substrates.
- Quesnel, Jeffrey S.,Arndtsen, Bruce A.
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supporting information
p. 16841 - 16844
(2013/12/04)
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- Synthesis and antibacterial activity of some 5,5'-(1,4-phenylene)-bis-1,3, 4-oxadiazole and bis-1,2,4-triazole derivatives as precursors of new S-nucleosides
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Five compounds, namely 5,5'-benzene-1,4-diylbis(1,3,4-oxadiazole-2-thiol)6 and 5,5'-benzene-1,4-diylbis(1H-1,2,4-triazole-3-thiol) 7a and its derivatives 7b-d were synthesized. Two related S-nucleosides 9 and 10 have been prepared from 6 and 7a. Some of these synthesized compounds were tested in vitro by spotting on Mueller Hinton Agar medium against some Gram-positive bacteria, Staphylococcus aureus and Enterococcus faecalis and three Gram-negative bacteria Escherichia coli, Pseudomonasaeruginosa, Pseudomonas fluorescens and compared with the known antibiotics cephalosporin (cefotaxim) and gentamycin. Compound 6 showed significant inhibitory activity against Gram-positive E. faecalis and Gram-negative E. coli bacteria while the others have shown variable inhibition activity.
- Datoussaid, Yazid,Othman, Adil A.,Kirsch, Gilbert
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experimental part
p. 30 - 35
(2012/06/04)
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- Metal-organic polyhedra containing 36 and 24 folds of amide groups for selective luminescent recognition of natural disaccharides
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An octa-nuclear bicoronal Ce-based triangular prism and tetra-nuclear molecular tetrahedron containing 36 and 24 folds amides within their main backbones were achieved and structurally characterized for the selective luminescent recognition of lactose and sucrose, respectively, over other related natural mono- and disaccharides.
- Jiao, Yang,Zhang, Jing,Zhang, Lejie,Lin, Zhihua,He, Cheng,Duan, Chunying
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supporting information; experimental part
p. 6022 - 6024
(2012/07/01)
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- Synthesis and nucleating effect of N, N'-Bis(Benzoyl) terephthalic acid dihydrazide
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N, N'-Bis(benzoyl) terephthalic acid dihydrazide(NA) was synthesized from benzoyl hydrazine and terephthaloyl chloride which was deprived from terephthalic acid via acylation, and the structures of the synthesized compound had been characterized by Fourie
- Cai, Yan-Hua
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experimental part
p. 709 - 712
(2012/10/07)
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- Efficient two directional syntheses of a homophthalate ester and novel resorcylate oligomers
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Thermolysis of 6,6′-(2-oxopropane-1,3-diyl)bis(2,2-dimethyl-4H-1,3- dioxin-4-one) in the presence of methanol gave a triketo-ester which subsequently aromatized to provide a synthetically useful homophthalate ester. Enolate C-acylation in the presence of diethylzinc was used to synthesize other double diketo-dioxinones, which on cyclization, aromatization and dioxinone ring opening gave novel double resorcylate derivatives.
- Patel, Bhavesh H.,Heath, Scott F.A.,Mason, Andrew M.,Barrett, Anthony G.M.
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supporting information; experimental part
p. 2258 - 2261
(2011/05/05)
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- PROCESS FOR THE PREPARATION OF HIGHLY PURE BEXAROTENE
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The present invention provides an improved process for the preparation of highly pure bexarotene of formula (I). The present invention also provides impurities of bexarotene, method of isolation and identification of these impurities, and use of these impurities as reference marker as well as reference standard.
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Page/Page column 22
(2011/12/02)
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- Single-pot conversion of an acid to the corresponding 4-chlorobutyl ester
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A single pot conversion of carboxylic acids into the corresponding 4-chlorobutyl esters has been achieved by a novel procedure. The intermediate acid chlorides are not isolated. The double bond and aromatic methoxy group survive the mild reaction conditions. In almost all the examples studied the products are purified by simple flash chromatography.
- Pal, Sutanuka,Pal, Sudhir Chandra
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experimental part
p. 596 - 599
(2012/04/18)
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- Bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides: A Novel Class of Potent Cytotoxins
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The principal objective of this study was the examination of the theory of cytotoxic synergism. In this exploratory study, we tested the hypothesis that doubling the number of sites available for thiol alkylation in a series of candidate cytotoxins increases potency more than two-fold. This concept was verified in one-third of our comparisons using human Molt 4/C8 and CEM T-lymphocytes and murine L1210 cells. In addition, the significant potencies of various members of our compound series justified further studies. Molecular modeling revealed that relative locations of the amidic groups correlate with cytotoxicity. A potent cytotoxic compound, 1,2-bis(3,5-dibenzylidene-4-oxo-piperidin-1-yl)ethane-1,2-dione (1a) inhibited the growth of a large number of human tumor cell lines and displayed greater toxicity toward certain non-adherent cells than toward adherent neoplasms or fibroblasts. The mode of action of 1a includes induction of apoptosis and necrosis.
- Das, Swagatika,Das, Umashankar,Varela-Ramirez, Armando,Lema, Carolina,Aguilera, Renato J.,Balzarini, Jan,DeClercq, Erik,Dimmock, Stephen G.,Gorecki, Dennis K. J.,Dimmock, Jonathan R.
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experimental part
p. 1892 - 1899
(2012/07/03)
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- From carboxylic acids to the trifluoromethyl group using BrF3
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Organic trifluoromethyl derivatives were made from aromatic and aliphatic carboxylic acids by transforming them first into the corresponding dithioesters followed by reaction with bromine trifluoride under mild conditions (0 °C, 2 min).
- Cohen, Or,Mishani, Eyal,Rozen, Shlomo
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scheme or table
p. 3579 - 3582
(2010/07/04)
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