- Contra-thermodynamic Olefin Isomerization by Chain-Walking Hydroboration and Dehydroboration
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We report a dehydroboration process that can be coupled with chain-walking hydroboration to create a one-pot, contra-thermodynamic, short-or long-range isomerization of internal olefins to terminal olefins. This dehydroboration occurs by a sequence comprising activation with a nucleophile, iodination, and base-promoted elimination. The isomerization proceeds at room temperature without the need for a fluoride base, and the substrate scope of this isomerization is expanded over those of previous isomerizations we have reported with silanes.
- Bloomer, Brandon,Butcher, Trevor W.,Ciccia, Nicodemo R.,Conk, Richard J.,Hanna, Steven,Hartwig, John F.
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p. 1005 - 1010
(2022/02/10)
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- WAX COMPOSITIONS COMPRISING LINEAR OLEFIN DIMERS OR HODROGENATED VARIANTS THEREOF AND METHODS FOR PRODUCTION THEREOF
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Wax compositions may be obtained by providing an olefinic feed comprising a first linear alpha olefin having m carbon atoms and a second linear alpha olefin having n carbon atoms, wherein m and n are independently selected integers each ranging from about 12 to about 100, and the olefinic feed optionally comprises one or more internal olefins and/or one or more branched olefins; contacting the olefinic feed with a metal carbene catalyst in a reactor; forming ethylene and a hydrocarbon substance comprising a linear olefin dimer comprising two carbon atoms less than a sum of m and n; removing the ethylene from the reactor while forming the linear olefin dimer; and isolating a wax composition comprising the linear olefin dimer, a hydrogenated reaction product thereof, or any combination thereof.
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Paragraph 0142-0147; 150
(2021/09/17)
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- Towards mesostructured zinc imidazolate frameworks
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The transfer of supramolecular templating to the realm of metal-organic frameworks opens up new avenues to the design of novel hierarchically structured materials. We demonstrate the first synthesis of mesostructured zinc imidazolates in the presence of the cationic surfactant cetyltrimethylammonium bromide (CTAB), which acts as a template giving rise to ordered lamellar hybrid materials. A high degree of order spanning the atomic and mesoscale was ascertained by powder X-ray diffraction, electron diffraction, as well as solid-state NMR and IR spectroscopy. The metrics of the unit cells obtained for the zinc methylimidazolate and imidazolate species are a=(11.43±0.45), b=(9.55±0.35), c=(27.19±0.34)A, and a=(10.98±0.90), b=(8.95±0.95), c=(26.33±0.34)A, respectively, assuming orthorhombic symmetry. The derived structure model is consistent with a mesolamellar structure composed of bromine-terminated zinc (methyl)imidazolate chains interleaved with motionally rigid cationic surfactant molecules in an all-trans conformation. The hybrid materials exhibit unusually high thermal stability up to 300°C, at which point CTAB is lost and evidence for a thermally induced transformation into poorly crystalline mesostructures with larger feature sizes is obtained. Treatment with ethanol effects the extraction of CTAB from the material, followed by facile transformation into pure microporous ZIF-8 nanoparticles within minutes, thus demonstrating a unique transition from a mesostructure into a microporous zinc imidazolate.
- Junggeburth, Sebastian C.,Schwinghammer, Katharina,Virdi, Kulpreet S.,Scheu, Christina,Lotsch, Bettina V.
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body text
p. 2143 - 2152
(2012/03/26)
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- Odd-even effect and unusual behavior of dodecyl-substituted analogue observed in the crystal structure of alkyltrimethylammonium-[Ni(dmit) 2]- salts
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A series of [Ni(dmit)2]- (dmit: 1,3-dithiole-2- thione-4,5-dithiolato) salts of alkyltrimethylammonium (Cn: n represents the alkyl chain length; n = 3 and 518) have been prepared and analyzed by X-ray structural analysis. All complex salts have been found to be composed of alternate sheets of [Ni(dmit)2]- anions and sheets of cations with a pronounced interdigitation of the alkyl chains. However, molecular arrangement differed between (C3)[Ni(dmit)2] and other (Cn)[Ni(dmit)2] (n = 518). Adjacent cations were aligned along the long axis of [Ni(dmit)2]- anion in C3 complex salt, while in others (C5-C18 complex salts), they were aligned toward the short axis. Such a difference in arrangement arose from correlativity between the lengths of the long axis of cation and anion, namely CLCA. Furthermore, relative orientation between the alkyl chain of cation and [Ni(dmit)2]- anion differed between the odd- and even-numbered cations for C10-C18. Whereas the plane of alkyl chain for odd-numbered cation was normal to the plane of [Ni(dmit)2]- anion, that of even-numbered cation was parallel. It was also found that C12 analog behaved like odd-numbered cations. However, in C12 salt, the end methyl group of the dodecyl group adopted unusual end-gauche conformation.
- Dai, Kotaro,Nomoto, Kuniharu,Ueno, Shinji,Tomono, Kazuaki,Miyamura, Kazuo
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experimental part
p. 312 - 319
(2011/05/13)
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- ACTIVE DELIVERY SYSTEMS FORMULATIONS
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The present invention relates to active delivery system formulations, and methods of making and using the same. Said formulations, when applied to a substrate surface, form a protective coating on the surface and permit constituent active agents to act on the surface and in the surrounding medium.
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- Method for activating denatured protein
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A method for activating a denatured protein, includes the steps of: adding a detergent to the denatured protein to allow a protein-detergent complex to be formed; and adding high-molecular weight amylose to the protein-detergent complex so that the high-molecular weight amylose removes the detergent.
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- Ion-exchange resins, their preparation and uses
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An ion-exchange resin stabilized against shrinkage, the resin being loaded with at least one amphiphilic ion in the absence of sodium cations. Also a process for removing iodide compounds from a liquid carboxylic acid and/or carboxylic acid anhydride obtained from the Group VIII noble metal catalysed, alkyl iodide co-catalysed carbonylation of alcohols and/or their reactive derivatives by contacting the liquid carboxylic acid and/or carboxylic acid anhydride with the ion-exchange resin stabilized against shrinkage as aforesaid, the ion-exchange resin being loaded with one or more of the metals silver, palladium or mercury.
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- Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
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The present invention discloses compositions containing lecithin and/or bactericidal compounds, and hydrophobic materials which form, upon application to dental surfaces, adhesive, protective and bacteria-inhibiting barriers.
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- Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
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The present invention discloses compositions containing a transfer agent and/or bactericidal compounds, and hydrophobic materials which form, upon application to dental surfaces, adhesive, protective and bacteria-inhibiting barriers.
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- Method for virus inactivation in the presence of polyalkylene glycol as well as the pharmaceutical preparation obtained therewith
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The invention relates to a pharmaceutical preparation comprising a plasma protein wherein said preparation is free of infectious agents as well as essentially free of denaturation products and is obtainable by a method that encompasses the following steps: a) addition of a polyether and a chaotropic agent to a solution comprising the plasma protein, optional lyophilization of the solution; b) inactivation of infectious agents in the presence of the polyether by a physio-chemical or chemical treatment, and c) removal of the polyether and the chaotropic agent.
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- Use of dimercaptan acids, salts and metabolites thereof as antiretroviral treatments
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A method for the prophylaxis or treatment of retroviruses in warm-blooded animals comprising administering to said warm-blooded animal a therapeutically effective amount of a dimercaptan acid, metabolites or pharmaceutically acceptable salts thereof alone or in combination with other drugs therapeutically effective in the treatment of said warm-blooded animal.
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- Interaction of Methyl Orange with Submicellar Cationic Surfactants
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The interaction of aqueous Methyl Orange (MO), an azo dye, with alkyltrimethylammonium and N-hexadecylpyridinium halide surfactants in submicellar concentration ranges has been investigated.The interaction gives rise to a new absorption band of MO with a maximum at ca. 370 nm, and the appearance of the new band has been attributed to change in the chromophore microenvironment in water structure enforced closely packed ion pairs of the dye with submicellar cationic surfactant.The strength of the interaction depends on the alkyl chain length of the surfactant, the surfactant head group and the counter ions.
- Dutta, Robin K.,Bhat, Subray N.
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p. 2457 - 2460
(2007/10/02)
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- Effect of Head-Group Size on Micellization and Phase Behavior in Quaternary Ammonium Surfactant Systems
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The micellization and phase equilibria in aqueous solutions of cationic quaternary ammonium bromide surfactants of the type alkyltrimethyl-, -ethyl-, -propy-, -butyl-, and -pentylammonium bromide have been investigated as a function of alkyl chain length, electrolyte concentration, and temperature.A large isotropic (micellar) phase is observed in triethyl- and tripropylammonium surfactants, which demixes into two conjugate phases on warming in the case of the alkyltributylammonium bromides.Liquid-liquid phase separation is also observed for tetradecyltripentylammonium bromide.Critical micelle concentrations are found to decrease with increasing hydrophobicity of the surfactant ion, but the free energy of micellization of tetradecyltributylammonium bromide is the same as that of tetradecyltrimethylammonium bromide over a range of temperatures.Some evidence is found for the formation of premicellar aggregates in tributylammonium surfactants at elevated temperatures, consistent with significant polydispersity and changing monomer concentrations observed previously.The results are discussed in terms of the hydrophobic and electrostatic contributions of the free energy of micellization, and some interferences are drawn regarding the nature of the interactions which give rise to phase separation.
- Buckingham, Scott A.,Garvey, Christopher J.,Warr, Gregory G.
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p. 10236 - 10244
(2007/10/02)
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- Dentifrice containing a poly(hydroxypropyl ether) non-ionic surfactant and a specified cationic polymer
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Dentifrice containing, in combination, (A) a poly(hydroxypropyl ether) nonionic surfactant, and (B) a cationic polymer selected from the group consisting of (i) a vinylpyrrolidone/dialkylaminoalkyl or -hydroxyalkyl acrylate or methacrylate, quaternized or nonquaternized and (ii) a cationic polysaccharide. This dentifrice is characterized by good foamability, pleasant taste and it does not attack the buccal mucosae and the gums.
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- 6,7-(epithio)-3,7-dimethyl-1,3-octadiene and use thereof in augmenting or enhancing aroma of perfume compositions, colognes and perfurmed articles
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Described are the 6,7-(epithio)-3,7-dimethyl-1,3-octadienes having the structures STR1 and mixtures of same as well as the uses thereof in augmenting or enhancing the aroma or perfume compositions, colognes and perfumed articles including but not limited to solid or liquid anionic, cationic, nonionic or zwitterionic detergents, cosmetic powders, hair preparations and the like.
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- Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins and methods of preparing such polysaccharides and conjugates
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Covalently-modified neutral bacterial polysaccharides; covalent conjugates of such polysaccharides linked by a bigeneric spacer, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides and conjugates.
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- Process for augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles with 1-phenylpenten-4-one-1 and methyl homologues thereof
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Described for use in augmenting or enhancing the aroma of perfume compositions, perfumed articles and colognes is the genus of compounds having the structure: STR1 wherein one of R1 or R2 is methyl and the other of R1 or R2 is hydrogen or wherein both R1 and R2 are hydrogen, hereinafter referred to as 1-phenylpenten-4-one-1 and methyl homologues thereof.
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- Process for preparing mixtures containing 8,9-epithio-1-p-menthene
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Described is a process for preparing a mixture of t-mercapto terpenes defined according to the structure: STR1 and α-terpineol defined according to the structure: STR2 including the step of reacting the compound defined according to the structure: STR3 with an alkali metal thiocyanate defined according to the structure: STR4 wherein M represents alkali metal such as sodium, potassium or lithium in the presence of a phase transfer catalyst. The resulting product is then treated with lithium aluminum hydride followed by aqueous mineral acid to form a mixture of α-terpineol and the compound defined according to the structure: STR5 which mixture is useful for its organoleptic properties.
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- Ether carbinols and process for preparing same
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Described are ether carbinols defined according to the generic structure: STR1 wherein X1 represents a moiety selected from the group consisting of: STR2 and wherein Y1 represents C4 or C5 alkylene or C4 or C5 alkenylene or C4 or C5 alkynylene; processes for preparing such ether carbinols by means of first reacting allyl ethers with a mixture of carbon monoxide and hydrogen by means of an oxoreaction to produce ether carboxaldehydes and then reducing the thus formed ether carboxaldehydes to ether carbinols; or reacting camphene with appropriate diols; as well as methods for augmenting or enhancing the aroma or taste of consumable materials including perfumes, colognes and perfumed articles; foodstuffs, chewing gums, chewing tobaccos, medicinal products and toothpastes; and smoking tobaccos and smoking tobacco articles by adding thereto an aroma or taste augmenting or enhancing quantity of the thus produced ether carbinols. Also described are two ether carboxaldehydes having one of the structures: STR3 processes for preparing such ether carboxaldehydes by means of reacting out an appropriate allyl ether with a mixture of carbon monoxide and hydrogen by means of an oxo-reaction as well as methods for augmenting or enhancing the aroma or taste of consumable materials including perfumes, colognes and perfumed articles; foodstuffs, chewing gums, chewing tobaccos, medicinal products and toothpastes; smoking tobaccos and smoking tobacco articles by adding thereto an aroma or taste augmenting or enhancing quantity of the thus produced ether carboxaldehydes.
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- Ether carboxaldehydes
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Described are ether carboxaldehydes defined according to the generic structure: STR1 wherein X represents aryl, alkaryl, hydroxyalkyl, alkenyl, cycloalkenyl, lower alkyl or bicycloalkyl; wherein Y represents C1 -C3 lower alkylene; wherein Z completes an alkyl substituted C6 cycloalkyl ring or represents no moiety; wherein R represents hydrogen or methyl; wherein m represents 0 or 1; wherein n represents 0 or 1; wherein p represents 0 or 1 and wherein q represents 0 or 1 with the provisos that when m is 1, Z completes the alkyl substituted or unsubstituted C6 cycloalkyl ring; that p is 1 when q is 0; and that when p is 0, q is 1, processes for producing same by reacting allyl ethers defined according to the structure: STR2 wherein x, y, z, m, n and r are as defined above with a mixture of carbon monoxide and hydrogen by means of an oxo reaction products produced according to said oxo reaction which are mixtures which contain the above-mentioned ether carboxaldehydes as well as methods for augmenting or enhancing the aroma or taste of consumable materials, including perfumes, colognes and perfumed articles; foodstuffs, chewing gums, chewing tobaccos, medicinal products and toothpastes; and smoking tobaccos and smoking tobacco articles by adding thereto aroma or taste augmenting or enhancing quantities of the thus produced ether carboxaldehydes or ether carboxaldehyde-containing mixtures. Also described are perfume compositions, colognes, perfumed articles (including solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions, drier-added fabric softener articles, hair preparations, deodorant compositions, bleaching compositions and perfumed polymers), foodstuffs, chewing gums, toothpastes, medicinal products, chewing tobaccos, smoking tobaccos and smoking tobacco articles containing the products thus produced.
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- The Behavior of 2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO) Irradiated in Aqueous Micellar Systems of Cetyl Trimethylammonium Bromide (CTAB)
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In the present paper the micellization effect on the γ-radiolysis of TEMPO in aqueous solutions was studied.The Decomposition yield G(-TEMPO) in CTAB micellar systems deaerated or saturated with N2O was found equal to 1.8 and 2.8, respectively.Comparison of these values with the corresponding values 3.2 and 0, obtained in homogeneous aqueous solutions, leads to the conclusion that TEMPO is solubilized close to the surface of the micelles so that partial hydration of nitroxyl is allowed.Furthermore, results of irradiation in the presence of CTAB in concentrations lower than that of the critical micelle concentration are consistent with the assumption that TEMPO reacts with surfactant radicals, produced by attack of OH on CTAB-molecules. - Keywords: 2,2,6,6-Tetramethylpiperidine-1-oxyl / CTAB / Micellar systems / Radiolysis
- Anastassopoulou, Jane D.,Paleos, C. M.,Rakintzis, N. Th.
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- Effects of Single-Stranded n-Alkyl Amphiphiles on the Conformational and Dynamic Behavior of Lecithin Sonicated Bilayers and Micelles Studied by 13C NMR. A Measure of Lipid Resistance against Disruption of the Bilayer Orientation
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The triplet fine structures in the 13C NMR spectra of carbons in the ?-position to nitrogen in several n-alkyltrimethylammonium bromides (TAB's), DMPC, and DPPC have been studied in different aggregational states under conditions of enhanced proton noise decoupling.Under the same conditions, the signals of the hydrophobic tails of the lecithins could also be studied better than hitherto, mainly by virtue of relatively narrow signals.It is shown that relatively small changes in packing and lateral motions can be detected.Intercalation of several n-alkyltrimethylammonium bromides in lecithin vesicles causes no decrease of the lipid -N+(CH3)3 mobility around the CH2-CH2 head-group linkage nor a decrease in acyl chain mobility.Moreover, no changes in acyl chain kinking are detected.On the other hand, the incorporated TAB molecules are forced by the lecithin molecules toward severely restricted head-group and tail mobilities.For those combinations of PC and TAB's where the TAB 13C NMR signals are detectable, a change in the conformational equilibrium toward more extension is found.A packing model for the incorporation of TAB's in PC vesicles is presented which probably has a rather general validity.The behavior of mixed micelles of PC's and TAB's, originating from enhancing the latter's concentration, is also described.In these systems, mobilities and chain kinking are increased with respect to the vesicular state.
- Haan, Jan W. de,Weerd, Roel J. E. M. de,Ven, Leo J. M. van de,Buck, Henk M.
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p. 5093 - 5099
(2007/10/02)
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- Preparation of quaternary ammonium halides in powder or granular form
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Quaternary ammonium halides in powder or granular form are prepared by reacting tertiary amines and excess alkyl halides in the absence of solvent at elevated temperature and pressure and conducting the hot, pressurized reaction mixture into an area under lower pressure where the excess alkyl halides vaporize and the quaternary ammonium halides are recovered in powder or granular form.
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- Process for the production of allyl acetone
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A process is described for the preparation of allyl acetone (5-hexen-2-one) according to the reaction: STR1 wherein R is methyl or ethyl; X is chloro or bromo; M is sodium or potassium; and Q is sodium or potassium, the reaction being carried out (i) using a phase transfer agent and (ii) in a two phase system.
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- STUDY OF PHASE TRANSFER CATALYSIS BY LAYERED SCINTILLATION METHOD.
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The static and kinetic feature of the reaction of sodium cyanide with 1-bromoalkanes in the presence of various phase transfer catalysts was investigated in the oil/water system by using a layered scintillation method and the mechanism of catalytic action was discussed. From the measurement of equilibrium constants for both reactions of hexadecyltrimethylammonium cyanide with 1-bromooctane and of sodium cyanide with hexadecyltrimethylammonium bromide in organic phase, it was pointed out that the latter reaction was responsible for the advance of overall reaction. It is also found that majority of the phase transfer catalysts exist in the oil phase.
- Hideshima,Morinaga,Kimizuka
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- Process for preparing substituted oxyacetaldehydes and acetals thereof
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A process is described for the preparation of substituted oxyacetaldehydes and acetals thereof according to the reaction sequence: STR1 wherein R1 and R2 are each lower alkyl or R1 and R2, taken together form a lower alkylene group; wherein R3 is alkyl, alkenyl or alkadienyl and X is halogen selected from the group consisting of chlorine and bromine, the reaction (i) being carried out (1) using a "phase transfer agent" and (2) in a two phase system.
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- Solid, frozen stabilized hair dye
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A cosmetic composition which at ambient temperature comprises a solution in a water or hydroalcoholic solvent of at least one cosmetic component which in said solution at ambient temperature is not stable, can be preserved, stabilized and packaged by freezing said composition and storing it at a temperature below its freezing point.
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- 3-(2-Chloroallyloxy)-2(10)-pinene
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Described are processes and compositions for augmenting or enhancing the flavor and/or aroma of consumable materials including foodstuffs, chewing gums, medicinal products, toothpastes, perfumes, colognes, and perfumed articles using as the essential ingredient at least one C10 -terpene alkyl, alkenyl, haloalkenyl, and alkynyl ether and diether having the formula: wherein n is 1 or 2; the terpene group is a moiety having one of the structures: STR1 and R1 is one of C1 -C4 alkyl, C3 or C4 alkenyl, C3 alkynyl, or C3 haloalkenyl. The compounds wherein R1 is C2 -C4 alkyl, C3 or C4 alkenyl, C3 alkynyl or C3 haloalkenyl are novel compounds.
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- Process for preparing substituted cyclic acetals of oxyacetaldehydes and said cyclic acetals
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A process is described for the preparation of substituted oxyacetaldehydes and cyclic acetals thereof according to the reaction sequence: STR1 wherein R1 and R2, taken together form a lower alkylene group; wherein R3 is alkyl, alkenyl or alkadienyl and X is halogen selected from the group consisting of chlorine and bromine, the reaction (i) being carried out (1) using a phase transfer agent and (2) in a two phase system.
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- Substituted-1-acetyl-3,3-dimethylcyclohexane
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Described in a genus of substituted 1-acetyl-3,3-dimethylcyclohexanes having the structure: STR1 wherein R1 or one or both of R2 and/or R3 is methallyl and the other of R1 or R2 and/or R3 is hydrogen, a process for preparing same by means of reacting a methallyl halide with acetyl-3,3-dimethylcyclohexane using a phase transfer agent and in a two phase system according to the reaction: STR2 wherein X is chloro or bromo, processes for adding such 1-acetyl-3,3-dimethylcyclohexane derivatives to consumable materials whereby: (i) In foodstuffs and medicinal products, fatty, sweet, fruity, citrus, green and vegetable-like aromas and fatty, sweet, fruity, citrus, vegetable-like and waxy flavor characteristics are augmented or enhanced; (ii) In perfumes and perfumed articles, green, herbaceous, melony and fruity aromas with galbanum-like, ginger-like and citrusy nuances are imparted, augmented and/or enhanced; and (iii) In tobaccos and tobacco flavors, green, sweet, fruity, floral and Virginia tobacco-like flavor and aroma nuances are augmented and/or enhanced in the mainstream and in the sidestream on smoking and, in addition, prior to smoking and flavor composition, perfume compositions and tobacco articles and foodstuffs and perfumed articles containing such 1-acetyl-3,3-dimethylcyclohexane derivatives.
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- 1-(2-Methyl-2-propenyl)-3-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehyde and 1-(2-methyl-2-propenyl)-4-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehyde
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Described are the compounds 1-(2-methyl-2-propenyl)-3-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehyde and 1-(2-methyl-2-propenyl)-4-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehyde; and a process for preparing same by means of reacting a methallylic halide with a mixture of 3 and 4-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehyde using a phase transfer agent in a two phase system according to the reaction: STR1 wherein the carboxaldehyde moiety is bonded to the alpha-carbon atom or the beta-carbon atom, X is chloro or bromo and M is alkali metal, processes for adding such 1-(2-methyl-2-propenyl)-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehydes to consumable materials whereby: I. In foodstuffs and medicinal products, floral, muguet, coriander, fatty, green and creamy aroma and flavor characteristics are augmented or enhanced; Ii. In perfumes and perfumed articles, citrus, floral and fatty nuances are imparted, augmented and/or enhanced; and Iii. In tobaccos and tobacco flavor and aroma imparting or enhancing compositions, sweet, spicey, coriander-like, citrus/fruity notes are imparted, prior to, and, on smoking And tobacco, foodstuff, flavor and perfume compositions containing the 1-(2-methyl-2-propenyl)-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehydes.
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- Substituted norbornane derivatives
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Disclosed are compounds of the formula STR1 wherein the wavy line represents a carbon-carbon single or double bond, possessing organoleptic properties.
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- Process for preparing substituted oxyacetaldehydes and acetals thereof
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A process is described for the preparation of substituted oxyacetaldehydes and acetals thereof according to the reaction sequence: STR1 WHEREIN R1 and R2 are each lower alkyl or R1 and R2, taken together form a lower alkylene group; wherein R3 is alkyl, alkenyl or alkadienyl and X is halogen selected from the group consisting of chlorine and bromine, the reaction (i) being carried out (1) using a "phase transfer agent" and (2) in a two phase system.
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- Anticalculus composition
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This invention relates to an improved composition for inhibiting dental plaque and calculus formation, comprising zinc ions and a non-toxic, organoleptically acceptable antibacterial agent in an orally acceptable medium, and to a process for retarding the growth of dental plaque and calculus by application to the teeth of the above composition.
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- 1-Acetyl-3,3-dimethyl-(2-propenyl)cyclohexane
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Described is the compound 1-acetyl-3,3-dimethyl-(2-propenyl)cyclohexane, a process for preparing same by means of reacting an allylic halide with acetyl-3,3-dimethylcyclohexane using a phase transfer agent and in a two phase system according to the reaction: STR1 wherein X is chloro or bromo, processes for adding 1-acetyl-3,3-dimethyl-(2-propenyl)cyclohexane to consumable materials whereby: I. In foodstuffs and medicinal products, fruity, pineapple, allyl-caproate-like, galbanum and woody aroma characteristics are augmented or enhanced and rosey, ionone, oriental-like and woody flavor characteristics are augmented or enhanced; and Ii. In perfumes and perfumed articles, sweet, earthy, animal aromas with pineapple and ambery nuances and tobacco/animal notes are imparted, augmented and/or enhanced And flavor compositions and perfume compositions containing 1-acetyl-3,3-dimethyl-(2-propenyl)cyclohexane.
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- Process for producing cis-jasmone
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A process is described for the preparation of cis-jasmone according to the reaction: STR1 wherein X is chloro or bromo and wherein M is alkali metal, the reaction being carried out (1) using a phase transfer agent and (2) in a two phase system.
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- Process for the alkylation of α, β-unsaturated aldehydes
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A process is described for the preparation of alpha substituted unsaturated aldehydes according to the reaction: STR1 wherein one of the dashed lines is a double bond and the other of the dashed lines is a single bond; wherein R1 is allyl or benzyl, R2 is one of alkyl, aryl, alkenyl or alkoxyalkyl and R3 and R4 are each hydrogen or alkyl, with the proviso that when R3 is alkyl the dashed line between the β carbon atom and the γ carbon atom represents a double bond and when R3 is hydrogen, either of the dashed lines is a double bond, wherein X is chloro or bromo, and wherein M is alkali metal, the reaction being carried out (1) using a phase transfer agent, and (2) in a two phase system. Also described is the novel compound, 2,4,7-trimethyl-2,6-octadienal having uses in altering, modifying or enhancing the organoleptic properties of foodstuffs, perfume compositions and perfumed articles.
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