921-03-9

Basic information

• Product Name: 1,1,3-Trichloroacetone
• Synonyms: 1,1,3-trichloro-2-propanon;1,1,3-TRICHLORO-2-PROPANONE;1,1,3-TRICHLOROACETONE;1,1,3-TCA;1,1,3-TRICHLOROACETONE, WACKER QUALITY;2-Propanone, 1,1,3-trichloro-;1,1,3-TRICHLOROPROPANONE
• CAS NO: 921-03-9
• Molecular Formula: C₃H₃Cl₃O
• Molecular Weight: 161.41
• EINECS: 213-063-6
• Mol File: 921-03-9.mol

Chemical Properties

• Melting Point: 9-11 °C(lit.)
• Boiling Point: 88-90 °C76 mm Hg(lit.)
• Flash Point: 80
• Appearance: colorless liquid
• Density: 1.512 g/mL at 20 °C(lit.)
• Vapor Pressure: 30-350Pa at 20-50℃
• Refractive Index: n20/D 1.491
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform, Methanol
• BRN: 1746647
• CAS DataBase Reference: 1,1,3-Trichloroacetone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,3-Trichloroacetone(921-03-9)
• EPA Substance Registry System: 1,1,3-Trichloroacetone(921-03-9)

Safety Data

• Hazard Codes: T+,N
• Statements: 25-26-34-50/53-68-21
• Safety Statements: 26-36/37/39-45-60-61-28
• RIDADR: UN 3390 6.1/PG 1
• WGK Germany: 3
• RTECS: UC3840000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 921-03-9(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
1,1,3-Trichloroacetone is used as a reagent for synthesizing chlorinated 5-hydroxy-4-methyl-2(5H)-furanones and mucochloric acid. It is also utilized in the synthesis of (+)-Phorbol, which is significant for biomedical research due to its ability to stimulate T-cell activation, proliferation, and cytokine production.
Used in Base-Induced Solvolysis:
1,1,3-Trichloroacetone is employed in base-induced solvolyses of [3.2.1]bicyclic α,α′-dichloro ketones, contributing to the advancement of chemical reactions and the development of new compounds.

Safety Profile

Poison by inhalation. Corrosiveand lachrymator. Mutation data reported. Combustibleliquid. When heated to decomposition it emits toxic fumesof Clí.

Synthetic route

acetone (67-64-1) → 1,1,3-trichloroacetone (921-03-9)

Conditions	Yield
Stage #1: acetone With 2-isopropylaniline for 1h; Reflux; Stage #2: With chlorine; sodium hydroxide at 60℃; under 3000.3 Torr; pH=8; Reagent/catalyst; Temperature; pH-value;	85%
Stage #1: acetone With 4,4'-bipyridine; chlorine In chlorobenzene at 20 - 30℃; for 2h; Stage #2: With 7,7',8,8'-tetracyanoquinodimethane In chlorobenzene at 50 - 60℃; for 5h; Reagent/catalyst;	83.2%
With chlorine at 30℃; Temperature;	48.1%
With nickel dichloride at 70℃; bei der Chlorierung;

Chloroiodomethane (593-71-5) + ethyl 1,1-dichloroacetate (535-15-9) → 1,1,3-trichloroacetone (921-03-9)

Conditions	Yield
With methyllithium; lithium bromide In tetrahydrofuran; diethyl ether at -78℃; for 0.333333h;	50%
1) tetrahydrofuran, diethyl ether, -78 deg C, 10 min, 2) water; Yield given. Multistep reaction;

diazomethane (186581-53-3, 908094-01-9) + dichloroacethyl chloride (79-36-7) + diethyl ether (60-29-7) → 1,1,3-trichloroacetone (921-03-9)

Conditions	Yield
at -10℃; bei der Behandlung des Reaktionsprodukts mit aether. HCl;

diazomethane (186581-53-3, 908094-01-9) + dichloroacethyl chloride (79-36-7) → 1,1,3-trichloroacetone (921-03-9)

Conditions	Yield
With diethyl ether Behandeln des Reaktionsgemisches mit aether.HCl bei -10grad;

chloroacetone (78-95-5) → 1,1,3-trichloroacetone (921-03-9)

Conditions	Yield
With chlorine at 30 - 40℃;
With chlorine at 40℃; under 750.075 Torr; for 10h; Product distribution / selectivity;

1-Chloro-2-propanol (127-00-4) → 1,1,3-trichloroacetone (921-03-9)

Conditions	Yield
With chlorine at 100℃; Irradiation.mit UV-Licht;

propylene glycol (57-55-6) → 1,1,3-trichloroacetone (921-03-9)

Conditions	Yield
With chlorine Irradiation;

1,3-Dichloro-2-propanol (96-23-1) → 1,1,3-trichloroacetone (921-03-9) + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With ruthenium(IV) oxide; sodium chloride In water; ethyl acetate at 5℃; Product distribution; other organic solvents;	A 1 % Chromat. B 62 % Chromat.

pentachloroacetone (1768-31-6) + (methyloxycarbonylmethyl)triphenylphosphonium bromide (1779-58-4) → 1,1,3-trichloroacetone (921-03-9) + methyl 3-(dichloromethyl)-4,4-dichlorocrotonate (97055-33-9)

Conditions	Yield
With triethylamine Product distribution; Mechanism; multistep reaction: 1.) THF, 24 h, room t., 2.) THF, 24 h reactions with var. chlorinated propanones under var. conditions;

chlorine (7782-50-5) + chloroacetone (78-95-5) → 1,1,3-trichloroacetone (921-03-9) + 1,1,1-trichloroacetone (918-00-3)

Conditions	Yield
at 30 - 40℃;

acetone (67-64-1) + NiCl2 → 1,1-Dichloroacetone (513-88-2) + 1,1,3-trichloroacetone (921-03-9) + chloroacetone (78-95-5) + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
at 70℃;

3-bromo-1,1-dichloro-propan-2-one → 1,1,3-trichloroacetone (921-03-9)

Conditions	Yield
With ethanol; mercury dichloride

1,1-Dichloroacetone (513-88-2) + chlorine (7782-50-5) → 1,1,3-trichloroacetone (921-03-9) + 1,1,1-trichloroacetone (918-00-3)

acetone (67-64-1) → 1,1-Dichloroacetone (513-88-2) + 1,1,3-trichloroacetone (921-03-9) + 1,1,1-trichloroacetone (918-00-3)

Conditions	Yield
With hydrogenchloride; chlorine at 20 - 80℃; for 8.5h;

chloroacetone (78-95-5) → 1,1-Dichloroacetone (513-88-2) + 1,1,3-trichloroacetone (921-03-9) + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With hydrogenchloride; platinum on carbon In water at 95 - 100℃; for 17h; Product distribution / selectivity;
With toluene-4-sulfonic acid; platinum on carbon In water at 95 - 100℃; for 17h; Product distribution / selectivity;
With toluene-4-sulfonic acid; lithium chloride; platinum on carbon In water at 95 - 100℃; for 17h; Product distribution / selectivity;

chloroacetone (78-95-5) → 1,1-Dichloroacetone (513-88-2) + 1,1,3-trichloroacetone (921-03-9) + 1,3-Dichloroacetone (534-07-6) + acetone (67-64-1)

Conditions	Yield
dihydrogen hexachloroplatinate In water at 95 - 100℃; for 17h; Product distribution / selectivity;
mercury dichloride In water at 95 - 100℃; for 17h; Product distribution / selectivity;
cobalt(II) chloride In water at 95 - 100℃; for 17h; Product distribution / selectivity;

1,3-Dichloroacetone (534-07-6) → 1,1,3-trichloroacetone (921-03-9)

Conditions	Yield
With chlorine; iron at 45 - 55℃; for 3h;	36.96 g

2-aminopyridine (504-29-0) + 1,1,3-trichloroacetone (921-03-9) → 2-(dichloromethyl)-2,3-dihydroimidazo[1,2-a]pyridin-2-ol hydrochloride

Conditions	Yield
In tetrahydrofuran at 20 - 70℃; for 16.5h;	100%

5-chloro-2-pyridylamine (1072-98-6) + 1,1,3-trichloroacetone (921-03-9) → 6-chloro-2-(dichloromethyl)-2,3-dihydroimidazo[1,2-a]pyridin-2-ol hydrochloride

Conditions	Yield
In tetrahydrofuran at 20 - 70℃; for 16.5h;	100%

C15H26O4Si + 1,1,3-trichloroacetone (921-03-9) → C18H30O5Si

Conditions	Yield
Stage #1: C15H26O4Si; 1,1,3-trichloroacetone With 2,2,2-trifluoroethanol; triethylamine Stage #2: With zinc In methanol Further stages.;	98%

2-aminopyridine (504-29-0) + 1,1,3-trichloroacetone (921-03-9) → imidazo[1,2-a]pyridine-2-carbaldehyde (118000-43-4) + 2-dichloromethylimidazo<1,2-a>pyridine (143982-35-8) + 2-diethoxymethylimidazo[1,2-a]pyridine (143982-36-9)

Conditions	Yield
In 1,2-dimethoxyethane for 4h; Ambient temperature;	A 5% B 90% C 5%

1,1,3-trichloroacetone (921-03-9) + N-(4-aminobenzoyl)-L-glutamic acid (4271-30-1) + 2,4,5-triamino-6-hydroxypyrimidine sulfate (35011-47-3) → folate (59-30-3)

Conditions	Yield
With sodium metabisulfite at 20 - 30℃; for 2h; Temperature; Ionic liquid;	83.2%
With sodium metabisulfite; sodium acetate at 45℃; for 3h; Temperature;	46.2%

2-aminopyrimidine (109-12-6) + 1,1,3-trichloroacetone (921-03-9) → C7H7Cl2N3O*ClH

Conditions	Yield
In tetrahydrofuran at 20 - 70℃; for 16.5h;	83%

2-aminopyridine (504-29-0) + 1,1,3-trichloroacetone (921-03-9) → imidazo[1,2-a]pyridine-2-carbaldehyde (118000-43-4)

Conditions	Yield
Stage #1: 2-aminopyridine; 1,1,3-trichloroacetone In tetrahydrofuran at 25℃; for 10h; Chichibabin Amination; Stage #2: With calcium carbonate In water at 100℃; for 1h;	82%

1,1,3-trichloroacetone (921-03-9) + N-(4-aminobenzoyl)-L-glutamic acid (4271-30-1) + 2,4,5-triamino-6-hydroxypyrimidine sulfate (35011-47-3) → (S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)pentanedioic acid (59-30-3)

Conditions	Yield
With sodium hydroxide at 55℃; for 9h; pH=3;	80%
Stage #1: 1,1,3-trichloroacetone; 2,4,5-triamino-6-hydroxypyrimidine sulfate With sodium metabisulfite In methanol; water for 0.5h; Large scale; Stage #2: N-(4-aminobenzoyl)-L-glutamic acid With sodium hydroxide In methanol; water at 40 - 45℃; for 6h; pH=3 - 3.5; Solvent; Large scale;	69.7%

1,1,3-trichloroacetone (921-03-9) + tert-butyl (furan-3-ylmethoxy)dimethylsilane (89861-06-3) → C14H24O3Si

Conditions	Yield
Stage #1: 1,1,3-trichloroacetone; tert-butyl (furan-3-ylmethoxy)dimethylsilane With sodium In 2,2,2-trifluoroethanol Stage #2: With zinc/copper couple In methanol	76%

1,1,3-trichloroacetone (921-03-9) + potassium ethyl xanthogenate (140-89-6) → C6H8Cl2O2S2

Conditions	Yield
In diethyl ether at -10 - -5℃; Inert atmosphere;	76%

1,1,3-trichloroacetone (921-03-9) + C10H13N3O3S → C13H14ClN3O4S

Conditions	Yield
With sodium acetate for 2h; Hantzsch Thiazole Synthesis; Reflux;	76%

1,1,3-trichloroacetone (921-03-9) + 4,5,6-trimethoxy-9-oxa-1-aza-cyclopenta[a]acenaphthylene (338730-12-4) → 16-aza-10,11,12-trimethoxy-18-oxapentacyclo[7.7.1.12,6.02,8.013,17]octadeca-1(16),7,9(10),11,13(17),14-hexaen-4-one (338730-21-5)

Conditions	Yield
Stage #1: 1,1,3-trichloroacetone; 4,5,6-trimethoxy-9-oxa-1-aza-cyclopenta[a]acenaphthylene With 2,2,2-trifluoroethanol; triethylamine at 20℃; for 72h; Foehlisch cycloaddition; Stage #2: With ammonium chloride; zinc In methanol at 20℃; for 10h; sonication; Further stages.;	73%

1,1,3-trichloroacetone (921-03-9) → 1,1,3,3-tetrachloropropanone (632-21-3) + pentachloroacetone (1768-31-6)

Conditions	Yield
With sulfuryl dichloride; N-benzyl-N,N,N-triethylammonium chloride at 55℃; for 168h;	A 72% B n/a

2-Amino-6-bromopyridine (19798-81-3) + 1,1,3-trichloroacetone (921-03-9) → 5-bromoimidazo[1,2-a]pyridine-2-carbaldehyde (878197-68-3)

Conditions	Yield
Stage #1: 2-Amino-6-bromopyridine; 1,1,3-trichloroacetone In 1,2-dimethoxyethane at 25 - 65℃; Inert atmosphere; Large scale reaction; Stage #2: With hydrogenchloride In 1,2-dimethoxyethane; water at 75℃; Large scale reaction; Stage #3: With sodium hydroxide In 1,2-dimethoxyethane at 10℃; pH=8; Large scale reaction;	72%
In 1,2-dimethoxyethane at 25 - 65℃; for 2 - 4h; Product distribution / selectivity;	72%
Stage #1: 2-Amino-6-bromopyridine; 1,1,3-trichloroacetone In 1,2-dimethoxyethane at 70℃; for 15h; Stage #2: In ethanol for 7h; Heating / reflux; Stage #3: With calcium carbonate In water for 1.5h; Product distribution / selectivity; Heating / reflux;	50%

1,1,3-trichloroacetone (921-03-9) + C5H7BrN2 → 5-bromoimidazo[1,2-a]pyridine-2-carbaldehyde (878197-68-3)

Conditions	Yield
With hydrogenchloride In 1,2-dimethoxyethane; water at 10 - 75℃;	72%

2-aminopyridine (504-29-0) + 1,1,3-trichloroacetone (921-03-9) → 2-dichloromethylimidazo<1,2-a>pyridine (143982-35-8)

Conditions	Yield
Stage #1: 2-aminopyridine; 1,1,3-trichloroacetone In 1,2-dimethoxyethane at 20℃; for 4h; Stage #2: In ethanol for 12h; Heating;	71%
In 1,2-dimethoxyethane; ethanol for 4h; Reflux;	5.2 g

1,1,3-trichloroacetone (921-03-9) + C15H15N3O3S → C18H16ClN3O4S

Conditions	Yield
With sodium acetate for 0.666667h; Hantzsch Thiazole Synthesis; Reflux;	71%

2-aminopyridine-3-carboxylic acid ethyl ester (13362-26-0) + 1,1,3-trichloroacetone (921-03-9) → ethyl 2-(dichloromethyl)imidazo[1,2-a]pyridine-8-carboxylate (1033434-43-3)

Conditions	Yield
In 1,2-dimethoxyethane at 20℃;	70%

2-aminopyridine-3-carboxylic acid ethyl ester (13362-26-0) + ethanol (64-17-5) + 1,1,3-trichloroacetone (921-03-9) → ethyl 2-(dichloromethyl)imidazo[1,2-a]pyridine-8-carboxylate (1033434-43-3) + ethyl 2-(diethoxymethyl)imidazo[1,2-a]pyridine-8-carboxylate (1033434-44-4)

Conditions	Yield
Stage #1: 2-aminopyridine-3-carboxylic acid ethyl ester; 1,1,3-trichloroacetone In 1,2-dimethoxyethane at 20℃; for 76h; Inert atmosphere; Stage #2: ethanol for 18h; Inert atmosphere; Reflux; Stage #3: With sodium hydrogencarbonate In water	A 70% B 4%

1,1,3-trichloroacetone (921-03-9) + 1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl) ethan-1-one N-ethyl thiosemicarbazone → C14H16ClN3O4S

Conditions	Yield
With sodium acetate for 1h; Hantzsch Thiazole Synthesis; Reflux;	66%

1,1,3-trichloroacetone (921-03-9) + 6-fluoro-pyridin-2-ylamine (1597-32-6) → 2-(dichloromethyl)-5-fluoroimidazo[1,2-a]pyridine (878197-91-2)

Conditions	Yield
In 1,2-dimethoxyethane at 85℃; for 15h;	65%
In 1,2-dimethoxyethane at 85℃; for 15h;	65%
In 1,2-dimethoxyethane at 85℃; for 15h; Product distribution / selectivity;	65%
In 1,2-dimethoxyethane at 85℃; for 15h;	65%
In 1,2-dimethoxyethane at 80℃; for 12h;	63%

1,1,3-trichloroacetone (921-03-9) + potassium O-neopentyl xanthate → C9H14Cl2O2S2

Conditions	Yield
In diethyl ether at -10 - -5℃; Inert atmosphere;	62%

2-Amino-3-bromopyridine (13534-99-1) + 1,1,3-trichloroacetone (921-03-9) → C8H5BrN2O (1194375-12-6)

Conditions	Yield
Stage #1: 2-Amino-3-bromopyridine; 1,1,3-trichloroacetone In 1,2-dimethoxyethane at 40 - 80℃; Stage #2: With N-ethyl-N,N-diisopropylamine In 1,2-dimethoxyethane at 80℃; for 60h; Stage #3: With calcium carbonate In water at 90℃; for 1h;	56%

1,1,3-trichloroacetone (921-03-9) + 4-(furan-3'-yl)butan-1-ol (90812-87-6) → 6-(4-hydroxy-butyl)-8-oxa-bicyclo[3.2.1]oct-6-en-3-one (619297-74-4)

Conditions	Yield
Stage #1: 1,1,3-trichloroacetone; 4-(furan-3'-yl)butan-1-ol With sodium 2,2,2-trifluoroethanolate In 2,2,2-trifluoroethanol at 0 - 20℃; for 72h; Stage #2: With copper(I) bromide; zinc In methanol at 20℃; for 48h;	54%

1,1,3-trichloroacetone (921-03-9) + sodium 2,2,2-trifluoroethanolate (420-87-1) + cyclopenta-1,3-diene (542-92-7) → 2,2-bis(2,2,2-trifluoroethoxy)bicyclo[3.2.1]oct-6-en-3-one

Conditions	Yield
Stage #1: 1,1,3-trichloroacetone; cyclopenta-1,3-diene In 2,2,2-trifluoroethanol at 0 - 20℃; for 1h; Stage #2: sodium 2,2,2-trifluoroethanolate In 2,2,2-trifluoroethanol for 10h; Heating;	53%

3,6-difluoropyridin-2-amine (944799-22-8) + 1,1,3-trichloroacetone (921-03-9) → 2-(dichloromethyl)-5,8-difluoroimidazo[1,2-a]pyridine (944799-23-9)

Conditions	Yield
In 1,4-dioxane at 50 - 100℃; for 120h;	52%

2-Aminopyrazine (5049-61-6) + 1,1,3-trichloroacetone (921-03-9) → 1,1-Dichloro-3-(pyrazin-2-ylamino)-propan-2-one

Conditions	Yield
In 1,2-dimethoxyethane for 3h; Heating;	47%

1,1,3-trichloroacetone (921-03-9) + C20H28O3 → C23H32O4 + C23H32O4

Conditions	Yield
Stage #1: 1,1,3-trichloroacetone; C20H28O3 With triethylamine In 1,1,1,3,3,3-hexafluoroisopropaol at 20℃; for 48h; Cooling with ice; Stage #2: With copper; ammonium chloride; zinc In methanol	A 46% B 47%

Upstream product

• 186581-53-3 diazomethane 
• 79-36-7 dichloroacethyl chloride 
• 60-29-7 diethyl ether 
• 78-95-5 chloroacetone 
• 67-64-1 acetone 
• 127-00-4 1-Chloro-2-propanol 
• 57-55-6 propylene glycol 
• 96-23-1 1,3-Dichloro-2-propanol 
• 593-71-5 Chloroiodomethane 
• 535-15-9 ethyl 1,1-dichloroacetate 
• 1768-31-6 pentachloroacetone 
• 1779-58-4 (methyloxycarbonylmethyl)triphenylphosphonium bromide 
• 7782-50-5 chlorine 
• 513-88-2 1,1-Dichloroacetone 

Downstream Products

• 59-30-3 folic acid 
• 874527-17-0 1-chloro-4-(α,β,β,β'-tetrachloro-isopropyl)-benzene 
• 89212-14-6 (2,2-dichloro-1-chloromethyl-1-hydroxy-ethyl)-phosphonic acid dimethyl ester 
• 118000-43-4 imidazo[1,2-a]pyridine-2-carbaldehyde 
• 143982-35-8 2-dichloromethylimidazo<1,2-a>pyridine 
• 143982-36-9 2-diethoxymethylimidazo[1,2-a]pyridine 
• 221558-19-6 4-dichloromethyl-2-phenylthiazole 
• 1197040-29-1 phenyl isocyanate 
• 116-16-5 1,1,1,3,3,3-hexachloro-propan-2-one 
• 1768-31-6 pentachloroacetone 
• 632-21-3 1,1,3,3-tetrachloropropanone 
• 878197-91-2 2-(dichloromethyl)-5-fluoroimidazo[1,2-a]pyridine 
• 878197-68-3 5-bromoimidazo[1,2-a]pyridine-2-carbaldehyde 
• 878197-67-2 5-fluoroimidazo[1,2-a]pyridine-2-carbaldehyde 

Relevant articles and documents

Preparation method of 1, 1, 3-trichloroacetone

The invention discloses a preparation method of 1, 1, 3-trichloroacetone. The preparation method comprises (1) under the existence of additives, subjecting acetone and chlorine for chlorination to obtain chlorinated intermediate solution; (2) adding radical scavenger into the obtained chlorinated intermediate solution, continuing to inletting chlorine for reaction under heating conditions, and processing reaction products to obtain the 1, 1, 3-trichloroacetone. The preparation method of the 1, 1, 3-trichloroacetone is implemented through two steps, and during the second step, a certain amountof the radical scavenger is added, so that selectivity and purity of the 1, 1, 3-trichloroacetone can be improved.

High-selectivity synthetic method for 1,1,3-trichloroacetone

The invention discloses a high-selectivity synthetic method for 1,1,3-trichloroacetone. The high-selectivity synthetic method includes the specific following steps that (1) 2-hydrocarbyl aniline and acetone are reacted to generate imine, chlorine is led for acetone chlorination, and meanwhile the pH of reaction liquid is kept with a sodium hydroxide solution; (2) after the chlorination reaction is completed, the pH value of the reaction liquid is adjusted by adjusting the adding quantity of the sodium hydroxide solution, imine is decomposed accordingly, 1,1,3-ichloroacetone and 2-alkyl aniline are obtained, filtering is carried out, and generated salt is removed; (3) filtered liquid is subjected to pressure reduction fractional distillation, and concentrated liquid after fractional distillation is the high-concentration-and-purity 1,1,3-trichloroacetone. By means of the high-selectivity synthetic method for the 1,1,3-trichloroacetone, the synthetic selectivity of the 1,1,3-trichloroacetone is effectively improved, the yield of a product is further increased, and the quality of the product is further improved; meanwhile, the device requirements are low, the safety factor is high, and the discharging amount of waste liquid is greatly reduced.

Preparation method for increasing synthetic yield of 1,1,3-trichloroacetone

The invention discloses a preparation method for increasing the synthetic yield of 1,1,3-trichloroacetone, and belongs to the technical field of organic synthesis. The method comprises the steps that a load type amine catalyst is prepared, a certain amount of ultra pure acetone is added into a reactor, the load type amine catalyst is slowly added in a stirring state, after the load type amine catalyst and ultra pure acetone are fully mixed to be uniform, temperature is increased, the temperature inside the reactor is controlled to be at 25 DEG C to 30 DGE C, chlorine starts to be introduced into the reactor under the stirring condition, after chlorine introduction is finished, the reaction temperature is controlled to be constant, stirring and thermal reacting continue to be conducted for 2 h, and then 1,1,3-trichloroacetone is obtained. According to the preparation method, the load type amine catalyst is used, the contact area with reactant is increased, the selectivity of 1,1,3-trichloroacetone is improved, and the yield of 1,1,3-trichloroacetone is further increased. According to the load type amine catalyst, load in a covalent bond connection mode is firm, and the catalyst can be recycled multiple times.

Preparing method for 1,1,3-trichloroacetone

The invention relates to a preparing method for 1,1,3-trichloroacetone. The preparing method comprises the following process steps that firstly, acetone and methyl alcohol serve as raw materials, an intermediate product 1,3-dichloroacetone dimethyl carbinol is obtained through chlorine chlorination preparation, a crude 1,1,3-trichloroacetone product is obtained through methyl alcohol stripping and deep chlorination, and a pure product is obtained through rectification. According to an improvement of the preparing mehtod, 1,3-dichloroacetone dimethyl carbinol easy to separate is prepared firstly from acetone, by-products 1,1-dichloroacetone and 1,1,1-trichloroacetone are separated out, then carbonyl is reduced through the method of introducing chlorine, new substances cannot be introduced, the purity of the end product1,1,3-trichloroacetone is high, and the total yield through the three-step reaction is high.

Process For Preparing Chlorinated Carbonyl Compounds In Jet Loop Reactors

The present invention relates to a process for preparing chlorinated or partly chlorinated carbonyl compounds, which comprises reacting unchlorinated or partly chlorinated carbonyl compounds with a chlorinating agent in a jet loop reactor.

PROCESS FOR PREPARING 1,3-DICHLOROACETONE

Epichlorohydrin is produced from acetone by (1) chlorinating acetone to form monochloroacetone; (2) disproportionating the monochloroacetone in the presence of a platinum catalyst, a strong acid and preferably a chloride source (for example, added as a salt or from hydrolysis of monochloroacetone) and some water to produce acetone and 1,3-dichloroacetone; (3) hydrogenating the 1,3-dichloroacetone in the presence of a catalyst to produce 1,3-dichlorohydrin; and (4) cyclizing the 1,3-dichlorohydrin with a base to produce epichlorohydrin.

Method for preparing chiral diphosphines

The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.

Synthesis of chlorinated 5-hydroxy 4-methyl-2(5H)-furanones and mucochloric acid

An improved procedure for the synthesis of chlorinated 5-hydroxy-4-methyl-2(5H)-furanones is described. By this method also carbon-labelled (13C and 14C at C-3) hydroxyfuranones, including mucochloric acid, can be prepared. Each step of the method was examined in an effort to optimize both the yield and the purity of the compounds.

A Simple and Unambiguous Synthesis of α,α- and α,α'-Dihalogeno Ketones

A convenient method for the unambiguous preparation of α,α'-dihalogeno ketones 3 from in situ-generated chloromethyllithium and α-chloro or α-bromo carboxylic acid esters 1 at -78 deg C, is described.The unambiguous prparation of α,α-dihalogeno ketones 7 by using in situ-generated dihalogenomethyllithium and carboxylic acid esters 5 at -78 deg C is also reported.