111-17-1Relevant articles and documents
PROCESS FOR PREPARING ?-MERCAPTOCARBOXYLIC ACID
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Paragraph 0088-0090, (2014/09/30)
There is provided a process for preparing β-mercaptocarboxylic acid represented by the following General Formula (3) comprising step of reacting hydrogen sulfide, alkali hydroxide represented by a formula: XOH (X represents Na or K), and unsaturated carboxylic acid represented by the following General Formula (1) under atmospheric pressure to obtain a reaction solution including a compound represented by the following General Formula (2) and step of neutralizing the reaction solution in an acid. An amount of the alkali hydroxide is equal to or greater than total moles of the unsaturated carboxylic acid and the hydrogen sulfide.
METHOD FOR PRODUCING BETA-MERCAPTOCARBOXYLIC ACID
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Paragraph 0064; 0065; 0066; 0067; 0068; 0069; 0070; 0077, (2014/10/15)
A process for preparing β-mercaptocarboxylic acid of the present invention is provided with Step a for reacting a compound represented by a formula: X12S (X1 represents hydrogen, Na or K) or a compound represented by a formula: X2SH (X2 represents Na or K), alkali hydroxide represented by a formula: X3OH (X3 represents Na or K), and unsaturated carboxylic acid represented by the following General Formula (1) to obtain a reaction solution including a compound represented by the following General Formula (2) and a compound represented by the following General Formula (3), Step b for neutralizing the reaction solution obtained in Step a with an acid to obtain a reaction solution including β-mercaptocarboxylic acid represented by the following General Formula (4) and a compound represented by the following General Formula (5), Step c for distillation-refining the reaction solution obtained in Step b to obtain the β-mercaptocarboxylic acid represented by General Formula (4), and Step d for returning a distillation residue including the compound represented by General Formula (5) in Step c to Step a.
A very useful and mild method for the deoxygenation of sulfoxide to sulfide with silica bromide as heterogeneous promoter
Mohanazadeh, Farajollah,Veisi, Hojat,Sedrpoushan, Alireza,Zolfigol, Mohammad Ali,Golmohammad, Fereshteh,Hemmati, Saba,Hashemi, Majid
, p. 7 - 13 (2014/01/06)
Silica bromide (SB) as heterogeneous reagent and promoter is prepared from reaction of silica gel with PBr3 as a non-hydroscopic, filterable, cheap, and stable yellowish powder that can be stored for months. The results show that the SB is suitable and efficient reagent for deoxygenation of sulfoxides to the corresponding sulfides under mild conditions at room temperature. The easy availability of this reagent makes this simple procedure attractive and a practical alternative to the existing methods.
Compositions of matter having bioactive properties
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, (2008/06/13)
Particles of coordinated complex comprising a basic, hydrous polymer and a capacitance adding compound, as well as methods for their production, are described. These complexes exhibit a high degree of bioactivity making them suitable for a broad range of applications through their incorporation into conventional vehicles benefiting from antimicrobial and similar properties.
Rationalisation of the regioselective hydrolysis of aliphatic dinitriles with Rhodococcus rhodochrous AJ270
Meth-Cohn, Otto,Wang, Mei-Xiang
, p. 1041 - 1042 (2007/10/03)
Aliphatic dinitriles undergo regioselective hydrolysis with the title organism to give monoacids with up to four methylenes between the nitrile functions (optimally 2-3) or when either an oxygen is placed β, γ or δ to the nitrile (δ-placement being optimal) or β or γ (optimally γ) but not δ sulfur substituents are present; nitrogen substituents appear to behave as for oxygen but suffer a steric limitation of the size of the nitrogen substituent.
Regioselective biotransformations of dinitriles using Rhodococcus sp. AJ270
Meth-Cohn, Otto,Wang, Mei-Xiang
, p. 3197 - 3204 (2007/10/03)
A variety of dinitriles have been hydrolysed selectively under very mild conditions using Rhodococcus sp. AJ270. Aliphatic dinitriles NC[CH2]nCN 1 undergo regioselective hydrolysis to give the mono acids 2 with up to 4 methylenes between the nitrile functions while those with n > 4 give the diacids 3 in good yield. Dinitriles NC[CH2]nX[CH2]nCN 4 bearing an ether or sulfide linkage are efficiently transformed into the mono acids 5 when an oxygen is placed β, γ or δ to the cyano group or a β- or γ-sulfur is present. Hydrolysis of N,N-bis(2-cyanoethyl)anilines 4h-j takes place slowly affording exclusively the monoacids 5h-j while the monocyano amides 5o-p are obtained as the sole isolable product from rapid hydrolysis of the corresponding N,N-bis(2-cyanomethyl)butylamine 4o and N,N-bis(3-cyanopropyl)butylamine 4p. Higher homologues of arylimino- and butylimino-dinitriles are inert to enzymatic hydrolysis. A variety of other aliphatic dinitriles have been converted readily into mono acids in good to excellent yields except for o-phenylenediacetonitrile which gives o-phenylenediacetamide as the major product. The title organism also effects the hydrolysis of aromatic dinitriles with regiocontrol such as m- and p-dicyanobenzenes, but nct the ortho-substituted analogue. The scope and limitations of this enzymatic process have been systematically studied and the mechanism of regioselective hydrolysis has been discussed in terms of a chelation-deactivation effect.
