13754-19-3Relevant articles and documents
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Gordon et al.
, p. 3245,3248,3250 (1957)
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3-deoxyglucosone and skin
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, (2008/06/13)
The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention also relates to methods of treating 3-deoxyglucosone and other alpha-dicarbonyl sugars associated diseases and disorders of skin.
Mechanisms for the Solvolytic Decomposition of Nucleoside Analogues. XI. Competitive Pathways for the Acidic Hydrolysis of 9-(β-D-Ribofuranosyl)purine
Loennberg, Harri,Heikkinen, Erkki
, p. 673 - 678 (2007/10/02)
Kinetics and product distributions of the hydrolysis of 9-(β-D-ribofuranosyl)purine have been examined over a wide acidity range.At high oxonium ion concentrations rate-limiting departure of the mono- and diprotonated purinyl group with concomitant formation of a glycosyl oxocarbenium ion constitutes the major reaction pathway, analogous to the hydrolysis of 6-substituted purine nucleosides.In slightly acidic solutions opening of the imidazole ring of the base moiety prevails, and 4-amino-5-formamidopyrimidine, formed as a relatively stable intermediate, undergoes further hydrolysis to 4,5-diaminopyrimidine or cyclization to purine, the product composition depending on the acidity of the reaction solution.Rate constants for the partial reactions have been calculated and the mechanisms of the individual steps are discussed.
Reaction of 9-(β-D-Ribofuranosyl)purine with Alkalies: Kinetics and Mechanism
Loennberg, Harri,Lehikoinen, Pertti
, p. 4964 - 4969 (2007/10/02)
The progress