1484-84-0Relevant articles and documents
Substituted Disulfonamide Compounds
-
Page/Page column 63, (2010/06/22)
Substituted disulfonamide compounds corresponding to formula I: In which R1, R2, R3, R4a, R4b, R5a, R5b, R8, R9a, R9b, R10, R11, a, b, s, t and A have defined meanings, pharmaceutical compositions containing one or more such compounds, processes for preparing such compounds, and a method of using such compounds for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin receptor 1 (BR1).
SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS
-
, (2008/06/13)
The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed
Process for preparing 2-piperidineethanol compounds
-
, (2008/06/13)
Described are preferred processes for producing 2-piperidineethanol compounds by hydrogenation of corresponding 2-pyridineethanol compounds. The preferred processes are conducted in the presence of an amine other than said reactant or product, and a hydrogenation catalyst preferably comprising a noble metal catalyst such as ruthenium or palladium or oxides thereof loaded to a high level in the system. The catalyst is preferably provided on a heterogeneous support, and most preferred processes are conducted using both controlled temperature conditions and high levels of catalyst to minimize the formation of deleterious byproducts.
Process for the preparation of hydroxyethylcyclohexanes and hydroxyethylpiperidines
-
, (2008/06/13)
Hydroxyethylcyclohexanes which can optionally contain a nitrogen atom in the cyclohexane ring are obtained in a particularly selective manner by catalytic hydrogenation of the corresponding hydroxyethylbenzene or hydroxyethylpyridines when ruthenium which has been treated before use with a reducing agent is used as catalyst.
1,2-DI-substituted piperidine derivative, hair growth promoter and external composition for skin using the same
-
, (2008/06/13)
A 1,2-di-substituted piperidine derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C1-30 expressed by R1 and the other is -(CH2)n-NR2R3; Y is -CO-, -CONR5- or -COO-; Z is -O-, -OCO-, -OCONR6- or -NR6-; R2 and R3 individually represent a hydrogen a lower alkyl, a phenyl or a benzyl group, or together represent a heterocycle having 3-7 members; -NR5-(CH2)n-NR2R3 and -NR6-(CH2)n-NR2R3 of -(Y)1-A and -Z-B may be the following Group W: wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R2 is a hydrogen, a lower alkyl, a phenyl or a benzyl group; R4 is a hydrogen, a halogen, a lower alkyl, a lower acyl, a nitro, a cyano, a lower alkoxycarbonyl, a carbamoyl, a lower alkylcarbamoyl, a lower alkylamino, a lower acylamino, a lower alkoxy or a lower acyloxy group; each of R5 and R6 is a hydrogen, a lower alkyl, a lower acyl, a lower alkylcarbamoyl group, or a part of said ring E; l is 0 or 1; m is an integer of 2-5; and n is an integer of 0-5. The 1,2-di-substituted piperidine derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.
5-HT3 receptor agonist, novel thiazole derivative and intermediate thereof
-
, (2008/06/13)
A 5-HT3 receptor against containing a thiazole derivative as the effective ingredient is provided and is represented by the Formula (I): STR1 wherein the A ring is substituted or unsubstituted and represents a benzene or a heterocyclic ring with one or two heteroatoms; one of L1 or L2 represents a single bond and the other is non-existent or represents an alkylene or alkenylene group; R represents: STR2
CYCLOADDITION OF 2,3,4,5-TETRAHYDROPYRIDINE N-OXIDE TO ISOBUTYL VINYL ETHER AND ALLYL ALCOHOL; METHYL 2-FORMYLMETHYLPIPERIDINE-1-CARBOXYLATE
Carruthers, William,Moses, Roger C.
, p. 2251 - 2254 (2007/10/02)
2,3,4,5-Tetrahydropyridine N-oxide undergoes cycloaddition with isobutyl vinyl ether and allyl alcohol to give the hexahydroisoxazolopyridines (3) and (4).In model experiments these were converted into methyl 2-formylmethylpiperidine-1-carboxylate (9).
