204-02-4 Usage
Description
Perimidine, also known as 4H-pyrimido[4,5-b][1,4]benzothiazine, is a heterocyclic compound that features a pyrimidine and benzothiazine ring system. It is characterized by its yellow crystalline solid form and is utilized in the synthesis of pharmaceuticals and agrochemicals. Perimidine derivatives have demonstrated potential in various applications, including anti-inflammatory, antiviral, and anticancer properties. They have also been explored for use as fluorescent probes and materials in organic electronic devices, as well as for the treatment of neurodegenerative diseases and in metal ion coordination chemistry. The versatility of perimidine and its derivatives makes them valuable in the fields of medicine, materials science, and coordination chemistry.
Uses
Used in Pharmaceutical Industry:
Perimidine is used as a key intermediate in the synthesis of various pharmaceuticals for its potential as an anti-inflammatory, antiviral, and anticancer agent. Its derivatives have shown promise in modulating biological pathways and mechanisms associated with inflammation, viral infections, and cancer, making them valuable in the development of new therapeutics.
Used in Agrochemical Industry:
In the agrochemical industry, perimidine is utilized as a component in the development of pesticides and other chemical products for agricultural applications. Its derivatives may possess properties that can help control pests and diseases in crops, contributing to increased crop yields and protection against various threats.
Used in Materials Science:
Perimidine is used as a material for organic electronic devices due to its electronic and optical properties. Its derivatives have been studied for their potential use in the creation of fluorescent probes and other advanced materials that can be integrated into electronic and optoelectronic systems.
Used in Coordination Chemistry:
Perimidine serves as a ligand in metal ion coordination chemistry, where it forms complexes with various metal ions. These complexes have potential applications in catalysis, sensing, and other areas of chemistry that require the specific properties conferred by metal-ligand interactions.
Used in Neurodegenerative Disease Treatment:
Perimidine derivatives have been investigated for their potential in treating neurodegenerative diseases. Their ability to interact with biological systems and modulate cellular processes makes them candidates for therapeutic intervention in conditions such as Alzheimer's and Parkinson's diseases.
Overall, perimidine and its derivatives have a wide range of applications across different industries, highlighting their importance in modern scientific and technological advancements.
Check Digit Verification of cas no
The CAS Registry Mumber 204-02-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,0 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 204-02:
(5*2)+(4*0)+(3*4)+(2*0)+(1*2)=24
24 % 10 = 4
So 204-02-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H8N2/c1-3-8-4-2-6-10-11(8)9(5-1)12-7-13-10/h1-7H,(H,12,13)
204-02-4Relevant articles and documents
Selective recognition of acetate ion by perimidinium-based receptors
Feng, Meiyun,Jiang, Xiaozhi,Dong, Zhiyun,Zhang, Dawei,Wang, Binshen,Gao, Guohua
, p. 6292 - 6296,5 (2012)
The first perimidinium-based receptors 1 and 2 have been designed and synthesized. The anion binding properties of the receptors were evaluated in DMSO by UV-vis, fluorescence spectroscopy, and 1H NMR methods. The results demonstrate that both receptors 1 and 2 exhibit good selectivity to acetate. The (C- H)+· · ·X- type ionic hydrogen bonding between the perimidinium moieties and acetate is the key interaction for the recognition.
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Barchet et al.
, p. 115 (1967)
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peri-Naphthylenediamines 31.* Study of interconversions of 2,3-dihydroperimidines and 1,8-bis(dialkylamino)naphthaienes. Convenient synthesis of 1,2,2,3-tetramethyl-2,3-dihydroperimidine and a monoisopropyl analog of the "proton sponge"
Ozeryanskii,Filatova,Sorokin,Pozharskii
, p. 846 - 853 (2001)
Efficient procedures were developed for the two-step synthesis of 1,2,2,3-tetramethyl-2,3-dihydroperimidines and for the one-step synthesis of 1,3-dimethyl-2,3-dihydroperimidines starting from 1,8-diaminonaphthalenes. New possibilities of the use of 2,3-dihydroperimidinium salts in the synthesis of 1,8-bis(dialkylamino)naphthalenes ("proton sponges") containing the N-isopropyl group along with the N-methyl groups were demonstrated. The 1,1,2,2,3-pentamethyl-2,3-dihydroperimidinium cation exists in the acyclic iminium form responsible for its high reactivity.
METHOD OF CARBON MONOXIDE FIXATION AND METHOD OF AMINE FORMYLATION
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Paragraph 0078; 0081-0085; 0100-0102, (2021/02/19)
The present invention relates to a method for fixing carbon monoxide in a metal-free condition and a method for formating amine using the same.
Metal-free Carbon Monoxide (CO) Capture and Utilization: Formylation of Amines
Noh, Hyeong-Wan,An, Youngjoon,Lee, Seulchan,Jung, Jaehoon,Son, Seung Uk,Jang, Hye-Young
, (2019/04/26)
The capture and utilization of CO by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) were performed in the absence of transition-metal complexes. The reaction of TBD with CO afforded TBD-CO adducts, which were converted to formylated TBD (TBD-CHO). TBD-CO adducts may include an interaction of CO with positively charged species based on NMR and IR analysis. In the presence of amines, CO was transferred from TBD-CO to amines, producing formylated amines with good yields. The reaction mechanism involving TBD-CO adducts is presented based on theoretical calculations. (Figure presented.).