Welcome to LookChem.com Sign In|Join Free

CAS

  • or

320-51-4

Post Buying Request

320-51-4 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

320-51-4 Usage

Chemical Properties

white to pinkish crystalline powder

Definition

ChEBI: A monochlorobenzene that is the 3-trifluoromethyl derivative of 4-chloroaniline.

Check Digit Verification of cas no

The CAS Registry Mumber 320-51-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,2 and 0 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 320-51:
(5*3)+(4*2)+(3*0)+(2*5)+(1*1)=34
34 % 10 = 4
So 320-51-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H2Cl2F6/c9-5-1-3(7(11,12)13)6(10)2-4(5)8(14,15)16/h1-2H

320-51-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (B21200)  4-Chloro-3-(trifluoromethyl)aniline, 99%   

  • 320-51-4

  • 5g

  • 190.0CNY

  • Detail
  • Alfa Aesar

  • (B21200)  4-Chloro-3-(trifluoromethyl)aniline, 99%   

  • 320-51-4

  • 25g

  • 638.0CNY

  • Detail
  • Alfa Aesar

  • (B21200)  4-Chloro-3-(trifluoromethyl)aniline, 99%   

  • 320-51-4

  • 100g

  • 2191.0CNY

  • Detail

320-51-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-amino-2-chlorobenzotrifluoride

1.2 Other means of identification

Product number -
Other names 2-CHLORO-5-AMINOBENZOTRIFLUORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:320-51-4 SDS

320-51-4Synthetic route

4-chloro-3-(trifluoromethyl)nitrobenzene
777-37-7

4-chloro-3-(trifluoromethyl)nitrobenzene

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With sodium tetrahydroborate; TPGS-750-M In tetrahydrofuran; water at 20℃; for 1h; Catalytic behavior; Reagent/catalyst;98%
With sodium tetrahydroborate In tetrahydrofuran; water at 20℃; for 2h; Inert atmosphere; Green chemistry; chemoselective reaction;94%
With sodium tetrahydroborate; iron; water at 20℃; for 2h;94%
3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With copper dichloride; 1-hexyl-3-methylimidazol-1-ium chloride at 40℃; for 8h; regioselective reaction;94%
1,4-dichloro-2-trifluoromethylbenzene
320-50-3

1,4-dichloro-2-trifluoromethylbenzene

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With ammonium hydroxide; potassium phosphate; copper(l) iodide; N1,N2-bis(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide In water; dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere;84%
Multi-step reaction with 2 steps
1: hydrazine hydrate; pyridine / ethyl acetate; dichloromethane / 4 h / 130 °C / Autoclave
2: Raney nickel / methanol / 1 h / Reflux
View Scheme
5-bromo-2-chlorobenzotrifluoride
445-01-2

5-bromo-2-chlorobenzotrifluoride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
Stage #1: 5-bromo-2-chlorobenzotrifluoride With magnesium In tetrahydrofuran Inert atmosphere;
Stage #2: With C10H17NO In tetrahydrofuran; toluene at -45℃; for 2h; Inert atmosphere;
Stage #3: With ammonium chloride In tetrahydrofuran; water; toluene Inert atmosphere;
61%
4-chloropicolinamide
99586-65-9

4-chloropicolinamide

4-amino-phenol
123-30-8

4-amino-phenol

A

4-(4-aminophenoxy)-2-pyridinecarboxamide
284462-80-2

4-(4-aminophenoxy)-2-pyridinecarboxamide

B

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With potassium tert-butylate; sodium chloride In methanol; hexane; ethyl acetate; N,N-dimethyl-formamideA 58%
B n/a
With potassium tert-butylate; sodium chloride In methanol; hexane; ethyl acetate; N,N-dimethyl-formamideA 58%
B n/a
With potassium tert-butylate; sodium chloride In methanol; hexane; ethyl acetate; N,N-dimethyl-formamideA 58%
B n/a
1-(4-bromophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)-5-thioxoimidazolidine-2,4-dione
1198619-79-2

1-(4-bromophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)-5-thioxoimidazolidine-2,4-dione

benzylamine
100-46-9

benzylamine

A

3-benzyl-5-(benzylimino)-1-(4-bromophenyl)imidazolidine-2,4-dione
1198619-80-5

3-benzyl-5-(benzylimino)-1-(4-bromophenyl)imidazolidine-2,4-dione

B

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
for 1h; Reflux;A 51%
B n/a
cloflucarban
369-77-7

cloflucarban

A

4-chloro-aniline
106-47-8

4-chloro-aniline

B

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 83℃; for 24h; Irradiation; further reagents, further conditions;
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 60 percent / HNO3; H2SO4 / 0.5 h / 50 - 60 °C
2: 65 percent / NaSH*9H2O; NaHCO3 / methanol; H2O / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: HNO3, H2SO4
2: H2 / PtO2
View Scheme
Multi-step reaction with 2 steps
1: nitric acid; sulfuric acid / 1 h / Heating
2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic anhydride; nitric acid / 3 h / 10 - 12 °C
2: iron(III) chloride hexahydrate; hydrazine hydrate / ethanol / 3 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid / water / 18 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2: iron; ammonium chloride; hydrogenchloride / ethanol; water / 2 h / 80 °C / Inert atmosphere; Schlenk technique
View Scheme
5-bromo-2-chlorobenzotrifluoride
445-01-2

5-bromo-2-chlorobenzotrifluoride

A

C14H7Cl2F6N
1445972-32-6

C14H7Cl2F6N

B

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 100℃; for 24h; Inert atmosphere; Overall yield = 72 %; Overall yield = 140.9 mg;
regorafenib
755037-03-7

regorafenib

A

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

B

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
In water; acetonitrile at 80℃; for 72h;
regorafenib
755037-03-7

regorafenib

A

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

B

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea
1333390-56-9

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea

C

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With hydrogenchloride at 80℃; for 5h;
methanol
67-56-1

methanol

regorafenib
755037-03-7

regorafenib

A

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

B

4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide

4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide

C

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With sodium hydroxide at 80℃; for 24h;
2-chloro-1-(trifluoromethyl)phenylhydrazine
91626-53-8

2-chloro-1-(trifluoromethyl)phenylhydrazine

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Conditions
ConditionsYield
With Raney nickel In methanol for 1h; Time; Reflux;8.6 g
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
In ethyl acetate at 80℃; for 1h;99.2%
In ethyl acetate at -5 - 80℃; for 3h; Solvent;95%
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

1,3-bis(4-chloro-3-(trifluoromethyl)phenyl)triazene

1,3-bis(4-chloro-3-(trifluoromethyl)phenyl)triazene

Conditions
ConditionsYield
With SHNC In water for 25h; Ambient temperature;99%
chloroacetyl chloride
79-04-9

chloroacetyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

[(4-chloro-3-trifluoromethylphenyl)aminocarbonylmethyl]chloride
351-33-7

[(4-chloro-3-trifluoromethylphenyl)aminocarbonylmethyl]chloride

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃; Inert atmosphere;99%
With pyridine In dichloromethane at 0 - 20℃; for 2h;98%
With triethylamine In dichloromethane at 0℃; for 1.5h;84.7%
Stage #1: chloroacetyl chloride; 4-chloro-3-trifluoromethyl-aniline With sodium hydrogencarbonate In diethyl ether; water at 20℃; for 1h; Schotten-Baumann Reaction;
Stage #2: With hydrogenchloride In diethyl ether; water
With triethylamine In dichloromethane at 0℃; for 1.5h;
2-benzyl-1-oxo-1,2,3,4,4a,7,8,8a-octahydroisoquinoline-8-carboxylic acid

2-benzyl-1-oxo-1,2,3,4,4a,7,8,8a-octahydroisoquinoline-8-carboxylic acid

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

2-benzyl-N-(2,4-dichlorophenyl)-1-oxo-1,2,3,4,4a,7,8,8a-octahydroisoquinoline-8-carboxamide

2-benzyl-N-(2,4-dichlorophenyl)-1-oxo-1,2,3,4,4a,7,8,8a-octahydroisoquinoline-8-carboxamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 20℃; for 14h; Product distribution / selectivity; Inert atmosphere; Combinatorial reaction / High throughput screening (HTS);99%
tert-Butyl 2,2,2-trichloroacetimidate
98946-18-0

tert-Butyl 2,2,2-trichloroacetimidate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

tert-butyl(4-chloro-3-trifluoromethylphenyl)amine
1631962-34-9

tert-butyl(4-chloro-3-trifluoromethylphenyl)amine

Conditions
ConditionsYield
With copper(II) bis(trifluoromethanesulfonate) In nitromethane at 20℃; for 2h; Inert atmosphere;99%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

2-bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)acetamide

2-bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;99%
1-Adamantanecarbonyl chloride
2094-72-6

1-Adamantanecarbonyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

N-[4-chloro-3-(trifluoromethyl)phenyl]adamantane-1-carboxamide

N-[4-chloro-3-(trifluoromethyl)phenyl]adamantane-1-carboxamide

Conditions
ConditionsYield
With triethylamine In acetone at 90℃; for 3h; Inert atmosphere;99%
phenyl chloroformate
1885-14-9

phenyl chloroformate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

phenyl (4-chloro-3-(trifluoromethyl)phenyl) carbamate

phenyl (4-chloro-3-(trifluoromethyl)phenyl) carbamate

Conditions
ConditionsYield
With potassium carbonate In water; toluene at 20℃; for 1h; Cooling with ice;99%
sodium isocyanate
917-61-3

sodium isocyanate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

4-chloro-3-trifluoromethylphenylurea
343247-69-8

4-chloro-3-trifluoromethylphenylurea

Conditions
ConditionsYield
With acetic acid In water at 40 - 50℃; for 2h; Temperature;97.2%
With acetic acid In water at 40 - 45℃; for 1 - 2h; Product distribution / selectivity;
With acetic acid In water at 40 - 45℃; Product distribution / selectivity;
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

p-ethoxycarbonylphenyl isocyanate
30806-83-8

p-ethoxycarbonylphenyl isocyanate

N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-ethoxycarbonylphenyl) urea

N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-ethoxycarbonylphenyl) urea

Conditions
ConditionsYield
In dichloromethane97%
In dichloromethane97%
In dichloromethane97%
In dichloromethane97%
In dichloromethane at 20℃;97%
tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate
145013-05-4

tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

N,N′-bis(tert-butoxycarbonyl)-N′′-4-chloro-3-(trifluoromethyl)guanidine
1443231-54-6

N,N′-bis(tert-butoxycarbonyl)-N′′-4-chloro-3-(trifluoromethyl)guanidine

Conditions
ConditionsYield
With tert.-butylhydroperoxide; iodine In water; toluene at 20℃;97%
With triethylamine; copper dichloride In dichloromethane at 20℃; for 16h;72%
With iodine; triethylamine In toluene at 0℃;65%
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

2-chloro-5-methoxyquinoline
160893-07-2

2-chloro-5-methoxyquinoline

N-(4-chloro-3-(trifluoromethyl)phenyl)-5-methoxyquinolin-2-amine

N-(4-chloro-3-(trifluoromethyl)phenyl)-5-methoxyquinolin-2-amine

Conditions
ConditionsYield
In neat (no solvent) at 160℃;97%
In neat (no solvent) at 160℃;
3-Bromobenzenesulfonyl chloride
2905-24-0

3-Bromobenzenesulfonyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

3-bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)benzenesulfonamide

3-bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)benzenesulfonamide

Conditions
ConditionsYield
With dmap In toluene at 55℃; Sealed tube;97%
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 140℃; for 4h; Temperature; Green chemistry;96.8%
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

S,S-dimethyl dithiocarbonate
868-84-8

S,S-dimethyl dithiocarbonate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydroxide In tetrahydrofuran at 35℃; for 1.33333h; Green chemistry;96.2%
5,7-dimethylisatin
39603-24-2

5,7-dimethylisatin

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

3-[(Z)-4-Chloro-3-trifluoromethyl-phenylimino]-5,7-dimethyl-1,3-dihydro-indol-2-one

3-[(Z)-4-Chloro-3-trifluoromethyl-phenylimino]-5,7-dimethyl-1,3-dihydro-indol-2-one

Conditions
ConditionsYield
grinding in agate mortar;96%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde
36663-00-0

1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde

diethyl (((4-chloro-3-(trifluoromethyl)phenyl)amino)(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methyl)phosphonate

diethyl (((4-chloro-3-(trifluoromethyl)phenyl)amino)(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methyl)phosphonate

Conditions
ConditionsYield
With Porcine Pancreas Lipase In neat (no solvent) at 45℃; Enzymatic reaction;96%
pivaloyl chloride
3282-30-2

pivaloyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

N-(4-chloro-3-trifluoromethylphenyl)-2,2-dimethylpropionamide
13691-92-4

N-(4-chloro-3-trifluoromethylphenyl)-2,2-dimethylpropionamide

Conditions
ConditionsYield
In triethylamine95%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 4h;60%
In triethylamine
In triethylamine
phenyl chloroformate
1885-14-9

phenyl chloroformate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

(4-chloro-3-trifluoromethylphenyl)carbamic acid phenyl ester
871555-75-8

(4-chloro-3-trifluoromethylphenyl)carbamic acid phenyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 5 - 20℃; for 2h;95%
In dichloromethane at 20℃; for 1h;94%
With pyridine In dichloromethane at 0 - 20℃;93.8%
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

4-azido-1-chloro-2-(trifluoromethyl)benzene
85862-78-8

4-azido-1-chloro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Stage #1: 4-chloro-3-trifluoromethyl-aniline With hydrogenchloride In water; acetonitrile at 20℃; for 0.333333h;
Stage #2: With sodium nitrite In water; acetonitrile at 20℃; for 1h;
Stage #3: With sodium azide In water; acetonitrile at 0 - 20℃; for 1h;
95%
Stage #1: 4-chloro-3-trifluoromethyl-aniline With hydrogenchloride; sodium nitrite In ethyl acetate at 0℃; for 0.5h;
Stage #2: With sodium azide In ethyl acetate at 20℃; for 2h;
62%
With sodium azide; sodium nitrite In acetonitrile at 0 - 5℃; for 1h;
4-amino-phenol
123-30-8

4-amino-phenol

urea
57-13-6

urea

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol
1129683-83-5

4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 130 - 135℃; for 3h; Temperature;94.8%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

1,3-diphenyl-4-formylpyrazole
21487-45-6

1,3-diphenyl-4-formylpyrazole

[(4-chloro-3-trifluoromethyl-phenylamino)-(1,3-diphenyl-1H-pyrazol-4-yl)methyl]phosphonic acid diethyl ester

[(4-chloro-3-trifluoromethyl-phenylamino)-(1,3-diphenyl-1H-pyrazol-4-yl)methyl]phosphonic acid diethyl ester

Conditions
ConditionsYield
With Porcine Pancreas Lipase In neat (no solvent) at 45℃; Enzymatic reaction;94%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

C17H11ClF3N3O2

C17H11ClF3N3O2

Conditions
ConditionsYield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 18h; Inert atmosphere;93.3%
difluoronitroacetyl chloride
336-94-7

difluoronitroacetyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

N-(4-Chloro-3-trifluoromethyl-phenyl)-2,2-difluoro-2-nitro-acetamide
123633-41-0

N-(4-Chloro-3-trifluoromethyl-phenyl)-2,2-difluoro-2-nitro-acetamide

Conditions
ConditionsYield
In diethyl ether at 29.9℃; for 0.5h;93%
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

3-Iodobenzoic acid
618-51-9

3-Iodobenzoic acid

N-[4-chloro-3-(trifluoromethyl)phenyl]-3-iodobenzamide

N-[4-chloro-3-(trifluoromethyl)phenyl]-3-iodobenzamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 70℃; for 20h;93%
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

Allyl chloroformate
2937-50-0

Allyl chloroformate

(4-chloro-3-trifluoromethyl aniline)carboxylic acid allyl ester

(4-chloro-3-trifluoromethyl aniline)carboxylic acid allyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In ethyl acetate at 0 - 5℃; for 2h; Reagent/catalyst; Solvent;92.5%
Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-2-oxoacetate
17738-62-4

ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-2-oxoacetate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;92%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere; Schlenk technique;87%
With triethylamine In dichloromethane at 20℃;
3-chloro-3-oxopropanoic acid methyl ester
37517-81-0

3-chloro-3-oxopropanoic acid methyl ester

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

methyl 3-((4-chloro-3-(trifluoromethyl)phenyl)amino)-3-oxopropanoate

methyl 3-((4-chloro-3-(trifluoromethyl)phenyl)amino)-3-oxopropanoate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;92%

320-51-4Relevant articles and documents

Characterization of degradation products of regorafenib by LC-QTOF-MS and NMR spectroscopy: Investigation of rearrangement and odd-electron ion formation during collision-induced dissociations under ESI-MS/MS

Baira, Shandilya Mahamuni,Srinivasulu, Gannoju,Nimbalkar, Rakesh,Garg, Prabha,Srinivas,Talluri, M.V.N. Kumar

, p. 12091 - 12103 (2017)

Regorafenib is an oral multikinase inhibitor, and it was subjected to stress conditions (hydrolysis, oxidative, thermal and photolytic) as per ICH specified conditions. The drug showed considerable degradation under hydrolysis (acidic, basic and neutral) and oxidative stress conditions, whereas it was stable under other stress conditions. A total of five degradation products (DPs) were observed and these were analyzed by using a UHPLC-DAD system. Chromatographic separation was achieved on an Acquity CSH C18 column (100 × 2.1 mm, 1.7 μ) using 0.1% formic acid and acetonitrile:methanol (80:20%, v/v) as the mobile phase in gradient mode. All DPs were characterized by LC-MS/MS, and the major degradation product (DP1) was isolated by using an HPLC preparative system from a degradation mixture and analyzed using NMR (1D and 2D NMR) and IR experiments. It was observed that protonated DP1 and DP3 undergo rearrangement reactions during collision-induced dissociations under positive electrospray ionization conditions. Additionally, in silico toxicity of the drug and its degradation products (DP1-DP5) was evaluated using TOPKAT and DEREK toxicity prediction software tools.

Catalytic production of anilines by nitro-compounds hydrogenation over highly recyclable platinum nanoparticles supported on halloysite nanotubes

Aepuru, Radhamanohar,Bustamante, Tatiana M.,Campos, Cristian H.,Leal-Villarroel, Edgardo,Mangalaraja, Ramalinga Viswanathan,Shanmugaraj, Krishnamoorthy,Torres, Cecilia C.,Vinoth, Victor

, (2021/07/28)

Pt-nanoparticles supported on halloysite-nanotubes (HNTs) were selectively deposited onto the inner (Pt(IN)/HNT) or outer (Pt(OUT)/HNT) surface of the support to evaluate their operational stability on the cleaner and efficient hydrogenation of nitro compounds to produce their corresponding anilines. The formation of Pt0-aggregates on the inner or outer surfaces was observed, with mean particles sizes of 2.4–2.9 nm. The catalysts were evaluated using ethanol as solvent and nitrobenzene as a model substrate at a temperature of 298 K, under 1 bar of H2 pressure. The Pt(IN)/HNT catalyst showed better catalytic performance than Pt(OUT)/HNT, which was mainly attributed to the confinement effect of the Pt-nanoparticles inside the HNTs. However, the operational stability showed that Pt(OUT)/HNT retained its catalytic performance after 15 cycles, while the Pt(IN)/HNT catalyst suffered deactivation after the 5th cycle. The best catalytic system showed a moderate-to-high efficiency in the efficient hydrogenation of 7 nitro compounds used to produce their corresponding anilines, which are important pharmaceutical building blocks.

Commercially Available CuO Catalyzed Hydrogenation of Nitroarenes Using Ammonia Borane as a Hydrogen Source

Du, Jialei,Chen, Jie,Xia, Hehuan,Zhao, Yiwei,Wang, Fang,Liu, Hong,Zhou, Weijia,Wang, Bin

, p. 2426 - 2430 (2020/03/30)

Tandem ammonia borane dehydrogenation and nitroarenes hydrogenation has been reported as a novel strategy for the preparation of aromatic amines. However, the practical application of this strategy is subjected to the high-cost and tedious preparation of supported noble metal nanocatalysts. The commercially available CuO powder is herein demonstrated to be a robust catalyst for hydrogenation of nitroarenes using ammonia borane as a hydrogen source under mild conditions. Numerous amines (even sterically hindered, halogenated, and diamines) could be obtained through this method. This monometallic catalyst is characteristic of support-free, excellent chemoselectivity, low-cost, and high recyclability, which will favor its future utilization in preparative reduction chemistry. Mechanistic studies are also carried out to clarify that diazene and azoxybenzene are key intermediates of this heterogeneous reduction.

Regorafenib analogues and their ferrocenic counterparts: Synthesis and biological evaluation

Wilde, Myron,Arzur, Danielle,Baratte, Blandine,Lefebvre, Dorian,Robert, Thomas,Roisnel, Thierry,Le Jossic-Corcos, Catherine,Bach, Stéphane,Corcos, Laurent,Erb, William

supporting information, p. 19723 - 19733 (2020/12/04)

Approved by the FDA in 2012, regorafenib is one of the last chance treatments for colorectal cancer. While various analogues have already been prepared, ferrocenic derivatives have never been evaluated. In this study, we prepared various ferrocene-containing derivatives of regorafenib and recorded their biological activity in kinase and cellular assays. This led to the identification of a squaramide derivative which shows a good cellular activity and three ferrocene analogues with promising activity in both kinase and cellular assays. This journal is

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 320-51-4