3943-89-3Relevant articles and documents
Modular Fragment Synthesis and Bioinformatic Analysis Propose a Revised Vancoresmycin Stereoconfiguration
Adamek, Martina,Essig, Sebastian,Kurz, Michael,Menche, Dirk,Sch?nenbroicher, Max,Seul, Maximilian,Spindler, Stefanie,Wingen, Lukas M.,Ziemert, Nadine
supporting information, p. 1175 - 1180 (2021/01/13)
Elaborate fragments of the proposed stereostructure of the complex polyketide antibiotic vancoresmycin have been synthesized in a stereoselective fashion based on a modular and convergent approach. Significant nuclear magnetic resonance differences in one of these subunits compared with the natural product question the proposed stereoconfiguration. Consequently, an extensive bioinformatics analysis of the biosynthetic gene cluster was carried out, leading to a revised stereoconfigurational proposal for this highly potent antibiotic.
Synthesis and application of acrylic resin based on protocatechuic acid
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Paragraph 0049-0050; 0053-0054, (2021/06/26)
The invention discloses synthesis and application of acrylic resin based on protocatechuic acid. According to the method, protocatechuic acid is used as a raw material, firstly, alcohol is used for esterification, and then the raw material and acryloyl chloride are synthesized into the protocatechuic acid-based acrylic resin monomer (M) through a one-pot method. And the acrylic resin based on protocatechuic acid is used for modifying polymethyl methacrylate (organic glass). The resin monomer is copolymerized with methyl methacrylate (MMA), the glass transition temperature (Tg) is increased along with the increase of the M content, and when the M content is 50%, the Tg of the copolymer is 159.6 DEG C (the heat resistance is improved by 51 DEG C). The Td5 of the copolymer is 358 DEG C (increased by 48 DEG C), and the residual carbon rate is 12.57%. In addition, the copolymerization product also shows the characteristic of absorbing short-wave blue light. The synthesis method provided by the invention is mild in reaction condition and relatively high in yield, and has a relatively great application prospect in the application field of optical electronics. The invention also widens the application range of biological resources.
Selective ether bond breaking method of aryl alkyl ether
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Paragraph 0070-0080, (2020/09/16)
The invention discloses a selective aryl alkyl ether cracking method, which comprises that aryl alkyl ether, aluminum iodide and an additive are subjected to a selective ether bond cleavage reaction in an organic solvent at a temperature of -20 DEG C to a reflux temperature to generate phenol and derivatives thereof. The method is mild in condition and simple and convenient to operate, is suitablefor cracking aryl alkyl ether containing o-hydroxyl and o-carbonyl and acetal ether, and can also be used for removing tertiary carbon hydroxyl protecting groups with higher steric hindrance, such astriphenylmethyl, tertiary butyl and the like.