467-55-0Relevant articles and documents
Steroidal saponins from the underground parts of Hosta longipes and their inhibitory activity on tumor promoter-induced phospholipid metabolism
Mimaki,Kanmoto,Kuroda,Sashida,Nishino,Satomi,Nishino
, p. 1190 - 1196 (1995)
Phytochemical study on the underground parts of Hosta longipes gave six new steroidal saponins together with a known one. The structures of the new compounds were determined by detailed analysis of their 1H- and 13C-NMR spectra including two-dimensional NMR spectroscopy, acid-catalyzed hydrolysis followed by chemical correlation, and by comparison with spectral data of known compounds. The isolated saponins and their aglycones were examined for inhibitory activity on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32P-incorporation into phospholipids of HeLa cells to identify new antitumor-promoter compounds.
SPIROSTANOL GLYCOSIDES FROM AGAVE CANTALA
Pant, G.,Sati, O. P.,Miyahara, K.,Kawasaki, T.
, p. 1491 - 1494 (1986)
Two spirostanol glycosides, cantalasaponins -2 and -4 were isolated from the methanolic extract of the rhizomes of Agave cantala and were characterized.The first glycoside was found to be lethal against Biomphalaria glabrata, tha snail vector of the disease schistosomiasis, at a concentration of 7 ppm. Key Word Index - Agave cantala; Agavaceae; saponins; spirostanol glycosides; schistosomiasis; Biomphalaria glabrata.
Photoinduced Deoxygenative Borylations of Aliphatic Alcohols
Wu, Jingjing,B?r, Robin M.,Guo, Lin,Noble, Adam,Aggarwal, Varinder K.
, p. 18830 - 18834 (2019/11/22)
A photochemical method for converting aliphatic alcohols into boronic esters is described. Preactivation of the alcohol as a 2-iodophenyl-thionocarbonate enables a novel Barton–McCombie-type radical deoxygenation that proceeds efficiently with visible light irradiation and without the requirement for a photocatalyst, a radical initiator, or tin or silicon hydrides. The resultant alkyl radical is intercepted by bis(catecholato)diboron, furnishing boronic esters from a diverse range of structurally complex alcohols.
Steroidal glycosides from the bulbs of Bessera elegans and their cytotoxic activities
Matsuo, Yukiko,Akagi, Nana,Hashimoto, Chisato,Tachikawa, Fumito,Mimaki, Yoshihiro
, p. 244 - 256 (2014/01/06)
Examination of the bulbs of Bessera elegans (Liliaceae) led to isolation of nine new and five known steroidal glycosides. The structures of the nine compounds were determined based on the results of spectroscopic analysis, including two-dimensional NMR, and hydrolysis followed by chromatographic and spectroscopic analysis. The isolated compounds and derivatives were evaluated for cytotoxicity against HL-60 human promyelocytic leukemia cells, A549 human lung adenocarcinoma cells, and TIG-3 normal human diploid fibroblasts. One compound, the pseudo-furostanol glycoside, induced apoptosis in HL-60 and A549 cells in a time-dependent manner and cell-cycle arrest at the G0/G1 phase in A549 cells.