505-54-4Relevant articles and documents
Preparation method of long-chain diacid
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, (2021/11/03)
The invention provides a preparation method of long-chain diacid, which comprises the following steps of: (S1) carrying out an addition reaction on olefine acid or an ester derivative thereof serving as a raw material and liquid bromine to obtain dibromo carboxylic acid or an ester derivative thereof; (S2) carrying out an elimination reaction on the dibromo carboxylic acid or ester derivative thereof under the action of sodium amide to obtain alkynyl-terminated carboxylic acid or an ester derivative thereof; (S3) carrying out an addition reaction on the alkynyl-terminated carboxylic acid or the ester derivative thereof and diborane to obtain borane or boric acid containing carboxyl or ester group; and (S4) oxidizing the borane or boric acid to obtain long-chain diacid. According to the invention, olefine acid is used as a raw material, is easily available in source and low in price, so that the production cost of the product is very low; and meanwhile, the raw materials used in the synthesis process do not contain precious metals or other expensive reagents, so that the synthesis process is suitable for industrial amplification production, and the defect that the method in the prior art is not environment-friendly, not suitable for industrial production and high in preparation cost is overcome.
Preparation method of long-chain alkyl diacid
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Paragraph 0070; 0085-0092; 0093; 0108-0115; 0116; 0131-0138, (2021/06/12)
The invention relates to a preparation method of long-chain alkyl diacid, belonging to the technical field of organic synthesis. The method is characterized in that long-chain alkyl diacid is prepared by hydrolyzing a long-chain alkyl acid derivative serving as a starting raw material under an acidic condition. According to the invention, a novel synthesis route is adopted, raw material cost is reduced, and the synthesis method has the characteristics of mild reaction conditions, simple process operation, low production cost and the like, and shows good application prospects. The long-chain alkyl diacid serving as an intermediate for medicine synthesis has very high application value and very high economic value.
Preparation method of long-chain alkyl diacid mono-tert-butyl ester
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Paragraph 0094; 0109-0116; 0126; 0142-0149; 0159; 0175-0182, (2021/06/13)
The invention relates to a preparation method of long-chain alkyl diacid mono-tert-butyl ester, belonging to the technical field of organic synthesis. According to the invention, long-chain alkyl diacid is used as an initial raw material and reacts with oxalyl chloride to generate long-chain monoacyl chloride, and the long-chain monoacyl chloride and tert-butyl alcohol are subjected to an esterification reaction to generate the long-chain alkyl diacid mono-tert-butyl ester. According to the invention, a novel synthesis route is adopted, and raw material cost is reduced; and the method has the characteristics of mild reaction conditions, simple process operation, high product purity, high production efficiency and the like, and has good application prospects.
cis/trans-Ozonides of Cycloolefins
Griesbaum, Karl,Ball, Volker,Beck, Johannes,McCullough, Kevin
, p. 1993 - 2000 (2007/10/03)
Ozonolyses in pentane of the unsubstituted cycloolefins having eleven-, twelve-, fourteen- and sixteen-membered rings (1b-e) and of cyclohexadecen-8-one (12) gave the corresponding cis- (2b-e; cis-15a) and trans-ozonides (3b-e; trans-15a), whereas cyclodecene (1a) gave only the corresponding cis-ozonide (2a).Ozonolyses on polyethylene of the dimethyl-substituted cycloolefins bearing fourteen- and sixteen-membered rings (7b,c) also afforded cis- and trans-isomeric ozonides (8, 9), whereas from the twelve-membered ring (7a) only the corresponding cis-ozonide (8a) was formed. - Keywords: Ozonides; Cycloolefins
One-step Synthesis of Long-chain Aliphatic α,ω-Dicarboxylic Acids Utilizing the Copper-catalyzed Reaction of β-Propiolactone with α,ω-Di-Grignard Reagents
Fujisawa, Tamotsu,Sato, Toshio,Kawara, Tatsuo,Tago, Hideyuki
, p. 345 - 346 (2007/10/02)
Copper-catalyzed reaction of β-propiolactone with α,ω-di-Grignard reagents, followed by esterification gave six-carbon homologated α,ω-dicarboxylic acid esters in good yields.
Free Acids in Lac Resin
Prasad, N.,Agarwal, S. C.,Chatterjea, J. N.,Sengupta, S. C.
, p. 980 - 983 (2007/10/02)
Lac resin has been found to contain 10.70 percent free fatty and 2.7 percent free aldehydic terpenic acids.The free fatty acids are composed of (i) saturated and unsaturated straight, chain lengths of C14, C16 and C18 (ii) 6-ketotetradecanoic , (iii) 6-hydroxytetradecanoic (butolic), (iv) 16-hydroxyhexadecanoic, (v) 16-hydroxyhexadec-cis-9-enoic, (vi) threo-9,10-dihydroxy of C14 and C16 chain lengths and (vii) threo-9,10,16-trihydroxy hexadecanoic (aleuritic) acids, while the terpenic acids constitute a mixture of jalaric, laccijalaric and a new aldehydic acid (C15H18O3).