78-90-0

Basic information

• Product Name: 1,2-Diaminopropane
• Synonyms: 1,2-PROPYLENEDIAMINE;1,2-PROPANEDIAMINE;1,2-DIAMINOPROPANE;12AP;PROPYLENE-1,2-DIAMINE;PROPYLENEDIAMINE;1,2-Proplenediamine;2,3-diaminopropane
• CAS NO: 78-90-0
• Molecular Formula: C₃H₁₀N₂
• Molecular Weight: 74.12
• EINECS: 201-155-9
• Product Categories: Intermediates of Dyes and Pigments;straight chain compounds;Aliphatics;Amines;Isotope Labeled Compounds;Isotope Labelled Compounds;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Polyamines
• Mol File: 78-90-0.mol

Chemical Properties

• Melting Point: -37 °C
• Boiling Point: 120-122 °C(lit.)
• Flash Point: 92 °F
• Appearance: /
• Density: 0.87 g/mL at 25 °C(lit.)
• Vapor Density: 2.6 (vs air)
• Vapor Pressure: 14 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.446
• Storage Temp.: Flammables area
• Solubility: H2O: very soluble
• PKA: 9.82(at 25℃)
• Explosive Limit: 2.2-11.1%(V)
• Water Solubility: SOLUBLE
• Sensitive: Air Sensitive & Hygroscopic
• Stability: Stable. Flammable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.
• Merck: 14,7852
• BRN: 605274
• CAS DataBase Reference: 1,2-Diaminopropane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Diaminopropane(78-90-0)
• EPA Substance Registry System: 1,2-Diaminopropane(78-90-0)

Safety Data

• Hazard Codes: C
• Statements: 10-21/22-35-42/43
• Safety Statements: 26-37/39-45-36/37/39-23
• RIDADR: UN 2258 8/PG 2
• WGK Germany: 1
• RTECS: TX6650000
• F: 3-10-23
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 78-90-0(Hazardous Substances Data)

Usage

Uses

1. Used in Electronics Industry:
1,2-Diaminopropane is used as a model precursor for the electron-induced deposition of amorphous carbon nitride films, which are essential in the development of advanced electronic devices and components.
2. Used in Chemical Analysis:
In conjunction with cupric sulfate, 1,2-Diaminopropane serves as a very sensitive reagent for detecting mercury, playing a crucial role in environmental and industrial monitoring of mercury contamination.
3. Used in Chemical Synthesis:
As a bidentate ligand, 1,2-Diaminopropane is utilized in the formation of coordination complexes, which are vital in various chemical reactions and synthesis processes across different industries.

Air & Water Reactions

Very hygroscopic. Very soluble in water.

Reactivity Profile

1,2-Diaminopropane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Flammable

Safety Profile

Moderately toxic by ingestion, sktn contact, and subcutaneous routes. A corrosive irritant to eyes, skin, and mucous membranes. Dangerous fire hazard when exposed to heat, flames, oxidizers. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx. Used as an intermedate in production of petroleum and polymer additives, and surfactants. See also AMINES.

Purification Methods

Purify the diamine by azeotropic distillation with toluene. Then distil it. Store it in a CO2 free atmosphere. [Horton et al. Anal Chem 27 269 1955, Beilstein 4 IV 1255.]

InChI:InChI=1/C3H10N2/c1-3(5)2-4/h3H,2,4-5H2,1H3/t3-/m0/s1

Upstream product

• 17147-63-6 1-nitro-2-nitroso-propane 
• 26198-63-0 1,2-Dichloropropane 
• 78-75-1 1,2-Dibromopropane 
• 408350-46-9 β-nitro-isopropylamine 
• 4232-41-1 1,2-dinitropropane 
• 78-96-6 3-amino-2-propanol 
• 51806-98-5 2-aminopropanenitrile 
• 75-55-8 2-Methylaziridine 
• 7664-41-7 ammonia 
• 64-19-7 acetic acid 
• 7647-01-0 hydrogenchloride 
• 138373-74-7 1-amino-2-azidopropane 
• 72187-91-8 α-amino propionitrile hydrochloride 
• 64-17-5 ethanol 

Downstream Products

• 1822-45-3 1,2-bis(dimethylamino)propane 
• 109-07-9 (RS)-2-methylpiperazine 
• 4408-81-5 1,2-diaminopropane-N,N,N',N'-tetraacetic acid 
• 89990-51-2 4-methyl-N-(1-methyl-2-{[(4-methylphenyl)sulfonyl]amino}ethyl)benzenesulfonamide 
• 72904-38-2 2,3-dihydro-2-methyl-5,6-diphenylpyrazine 
• 536753-86-3 2-methyl-dibenzo[f,h]quinoxaline 
• 78-90-0 (R)-1,2-diaminopropane 
• 65826-70-2 2,3-dihydro-2,5,6-trimethylpyrazine 
• 53672-36-9 2-(2-Chloro-phenyl)-N-{2-[2-hydroxy-3-(2-nitro-phenoxy)-propylamino]-propyl}-acetamide 
• 15332-55-5 C₂₅H₃₂Cl₄N₄ 
• 53673-50-0 1-methyl-2-(phenylacetamido)ethylamine 
• 53673-59-9 N-(2-Amino-propyl)-2-nitro-benzenesulfonamide 
• 61796-54-1 Pentanedioic acid {1-methyl-2-[4-(methyl-phenyl-carbamoyl)-butyrylamino]-ethyl}-amide methyl-phenyl-amide 

Relevant articles and documents

Synthesis of 1,2-propanediamine via reductive amination of isopropanolamine over Raney Ni under the promotion of K2CO3

Catalytic amination of isopropanolamine and ammonia to 1,2-propanediamine over Raney Ni with potassium carbonate as the additive was reported. Characterization of N2 adsorption–desorption and XRD were performed to reveal the textural and structural properties of the catalysts. With the additive of potassium carbonate, the selectivity of 1,2-propanediamine was improved, while the side generation of 2,5-dimethylpiperazine was suppressed. The catalytic reaction parameters were optimized and the yield of 1,2-propanediamine reached 80% under the optimized reaction condition.

Selective amination of 1,2-propanediol over Co/La3O4 catalyst prepared by liquid-phase reduction

The catalytic coupling of alcohol and ammonia is an environmentally friendly process. Cobalt-based catalysts, modified by supports (including CeO2, Fe3O4, Nb2O5, La3O4 and Al2O3), and prepared by the liquid-phase reduction, were used for the amination of 1,2-propanediol. The screened nano-Co/La3O4 catalyst exhibited an excellent catalytic performance of 68% conversion and 89% selectivity toward 2-amino-1-propanol under optimal conditions. The characterizations of the catalyst was performed by XRD, XPS, BET, TEM, TG, and CO2-TPD, revealing a relatively large specific surface area, strongly alkaline sites and a Co-La-O transition phase, which were responsible for the selective catalysis of 1,2-propanediol. The efficient construction of cobalt-based catalysts on the basis of the active species is key to improving the efficiency of the reaction process.

Method of synthesizing 2-methyltriethylenediamine with 2-methylpiperazine as raw material

The invention belongs to the field of fine chemical engineering and relates to a method of synthesizing 2-methyltriethylenediamine with 2-methylpiperazine as raw material. The method is to solve the problems of expensive and complicated raw materials and complex synthesis steps. The method can catalytically synthesize the 2-methyltriethylenediamine in one step only with the 2-methylpiperazine as araw material by means of TiO2/Pentasil zeolite as a catalyst. The method employs simple raw material, is simple and has high application value.

A phase transfer catalysis process for preparing 1, 2 - propylene diamine method

The invention introduces preparation of 1,2-propane diamine, and mainly emphasizes an application of a phase-transfer catalyst to reactions. A major reaction process comprises the following steps: (1) adding propylene dichloride, ammonia water, a catalyst and the phase-transfer catalyst into a reaction kettle; (2) putting the reaction kettle into which raw materials are added into a homogeneous phase reactor; (3) reacting at 140-170 DEG C and 25 Hz, evaporating unreacted ammonia gas under the normal pressure after the reaction is finished, and distilling to obtain an aqueous solution of propane diamine. The method disclosed by the invention has the advantages that the propylene dichloride being a byproduct produced in the production of epoxy chloropropane is taken as a raw material, i.e.,, waste is utilized, and thus the production cost is reduced; the phase-transfer catalyst is added in a reaction process, so that the reaction yield is greatly increased; meanwhile, the method is simple, is easy to operate, and is easy for realizing industrial production.

Production of Primary Amines by Reductive Amination of Biomass-Derived Aldehydes/Ketones

Transformation of biomass into valuable nitrogen-containing compounds is highly desired, yet limited success has been achieved. Here we report an efficient catalyst system, partially reduced Ru/ZrO2, which could catalyze the reductive amination of a variety of biomass-derived aldehydes/ketones in aqueous ammonia. With this approach, a spectrum of renewable primary amines was produced in good to excellent yields. Moreover, we have demonstrated a two-step approach for production of ethanolamine, a large-market nitrogen-containing chemical, from lignocellulose in an overall yield of 10 %. Extensive characterizations showed that Ru/ZrO2-containing multivalence Ru association species worked as a bifunctional catalyst, with RuO2 as acidic promoter to facilitate the activation of carbonyl groups and Ru as active sites for the subsequent imine hydrogenation.

The invention relates to a propylene glycol and liquid ammonia as raw materials for preparing propylene diamine method and apparatus thereof

The invention relates to a method for preparing propane diamine by taking propylene glycol and liquid ammonia as raw materials. Propylene glycol and liquid ammonia are mixed in a certain ratio and are pumped into a reactor by virtue of a pump, and reaction is carried out in presence of a catalyst and hydrogen. The method for preparing the propane diamine by taking the propylene glycol and liquid ammonia as the raw materials has the advantages that a novel catalyst is adopted, catalytic performance is excellent, and long-time operation can be easily carried out; propylene glycol is subjected to hydroamination for producing a propane diamine product at lower reaction pressure, and reaction conditions are adjusted and changed, so that composition of the product can be flexibly adjusted and changed, selectivity of a target product is improved, a reaction process is simple, one-time investment of a production unit and production cost are reduced, a reaction product and a catalyst can be simply separated, and large-scale continuous industrial production can be easily realized.

METHOD FOR PRODUCING 1,2-PROPYLENEDIAMINE

According to an aspect of the present invention, a manufacturing method of 1,2-propylenediamine adopts a catalyst-free method, and can save costs for a catalyst. Also, the manufacturing method of 1,2-propylene diamine can utilize conventional manufacturing equipment, thereby providing 1,2-propylenediamine with remarkable cost efficiency. The manufacturing method of the present invention makes 1,2-dichloropropane react with an ammonia solution through a catalyst-free method.COPYRIGHT KIPO 2016

A 1,2-propane diamine synthetic method

The invention relates to a synthesis method of 1,2-propane diamine. The method comprises the steps of preparing 1,2-propane diamine via reaction between isopropanolamine and liquid ammonia in the presence of hydrogen, a catalyst, an assistant and a reaction solvent. Compared with the prior art, since the reaction solvent is added, and due to solvation of the solvent and the reaction material, the probability of the reaction product 1,2-propane diamine continuing to participate in reaction to generate a cyclamine product is reduced; at the same time, the alkali metal and alkaline-earth metal assistant is added into a reaction system, and the base strength of the reaction system is changed, so that dehydrogenation of the catalyst to the reaction material is inhibited; and the selectivity of the product 1,2-propane diamine is improved.

FUNCTIONALIZED HIGHLY BRANCHED MELAMINE-POLYAMINE POLYMERS

The present invention relates to a method for producing amphiphilic functionalized highly branched melamine-polyamine polymers by condensing melamine and optionally a melamine derivate having at least one different amine having at least two primary amino groups and optionally also with urea and/or at least one urea derivative and/or with at least one at least difunctional diisocyanate or polyisocyanate and/or at least one carbolic acid having at least two carboxyl groups or at least one derivative thereof, optionally quaternizing a portion of the amino groups of the polymer thereby obtained, reacting the polymer thus obtained with at least one compound capable of undergoing a condensation or addition reaction with amino groups, and optionally quaternizing at least part of the amino groups of the polymer obtained in the first step. The invention further relates to the amphiphilic functionalized highly branched melamine-polyamine polymers that can be obtained by the method according to the invention, and to the use thereof as surface active agents.

Polymethacrylic zinc porphyrin: A new approach to chiral recognition

A methacrylic homopolymer bearing in the side-chain achiral zinc tetraarylporphyrin moieties, has been studied as macromolecular chromophoric host to determine the absolute configuration of α,ω-diamines. The polymeric material resulted able to bind the ch