80-17-1Relevant articles and documents
Investigation of spectroscopic, structural and non-linear optical properties of ethyl 3,5-dimethyl-4-[(benzenesulfonyl)-hydrazonoethyl]-1H-pyrrol- 2-carboxylate
Singh,Rawat, Poonam,Sahu, Sangeeta
, p. 123 - 133 (2013)
This paper describes the synthesis, spectroscopic 1H and 13C NMR, UV-Visible, FT-IR analysis, elemental analysis, structural evaluation and non-linear optical (NLO) properties of newly synthesized compound, ethyl 3,5-dimethyl-4-[(benzenesulfonyl)-hydrazonoethyl]-1H-pyrrol-2- carboxylate using experimental and quantum chemical techniques. FT-IR spectrum, electronic descriptors, molecular electrostatic potential surface (MEPS) and quantum theory of atoms in molecule (QTAIM) have been used to predict the sites and nature of interactions. A combined experimental and theoretical vibrational analysis identified red shifts in vNH and vCO as result of hydrogen bonding confirming formation of the dimer in the solid phase. The binding energy of dimer has been evaluated as 9.72 kcal/mol. The value of Gibbs free energy change (ΔG) shows that dimer formation is thermodynamically spontaneous. At room temperature, the equilibrium constant (Keq) for dimerization reaction is calculated to be 18.91 i.e. Keq a?‰
Electrochemical heterodifunctionalization of α-CF3alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols
Chen, Kai,Duan, Xin-Yu,Gao, Jie,Guan, Jian-Ping,Liu, Fang,Xiang, Hao-Yue,Xiao, Jun-An,Yang, Hua,Ye, Zhi-Peng
supporting information, p. 8969 - 8972 (2021/09/10)
An unprecedented electrochemical heterodifunctionalization of α-CF3alkenes with benzenesulfonyl hydrazides was accomplished in this work, wherein a β-sulfonyl and a α-hydroxyl group were simultaneously incorporated across the olefinic double bond in a single operation. Consequently, a series of potentially medicinally valuable and densely functionalized α-trifluoromethyl-β-sulfonyl tertiary alcohols were assembled under mild conditions. Electrochemically-driven oxidative 1,2-difunctionlization of electron-deficient alkenes well obviates the need for oxidizing reagents, thus rendering this protocol more eco-friendly.
Synthesis and hyperglycemic, biochemical and histopathological evaluation of novel sulfonylbiguanide and sulfonylurea derivatives as potent anti-diabetic agents
Basyouni, Wahid M.,Abbas, Samir Y.,El-Bayouki, Khairy A.M.,Younis, Eman A.,Ali, Sanaa A.,Aly, Hanan F.
, (2021/11/01)
New sulfonylbiguanide hydrochloride salts and sulfonylurea derivatives containing two sulfonyl groups were synthesized through the reaction of arylsulfonohydrazides with cyanoguanidine and p-tolylsulfonylisocyanate, respectively. Oral treatment of hyperglycemic rats with the synthesized sulfonylbiguanide derivatives 2 and sulfonylurea derivatives 3 revealed that sulfonylurea derivatives 3a and 3c possessed significant decrease of the elevated glucose in compression with the anti-diabetic standard drugs. Effects of the synthesized sulfonylurea derivatives 3a and 3c on the diabetic properties towards α-amylase, liver function enzyme levels (AST, ALT, ALP, TB and γ-GT), kidney functions (urea and creatinine), lipids profiles (TG, TL, TC and HDL-C) were studied. Also, the effect of sulfonylurea derivatives 3a and 3c as antioxidants (reduced glutathione and lipid peroxide) was evaluated. Histopathological examination of hepatic and pancreatic tissues was investigated. The obtained results suggested that the most potent sulfonylurea derivatives 3a and 3c might be possible used as novel diabetic inhibitor agents.
