Bergmann-Zervas Carbobenzoxy Method

M. Bergmann, L. Zervas, Ber. 65, 1192 (1932).

Formation of the N-carbobenzoxy derivative of an amino acid for use in peptide synthesis and liberation of the amino group at an appropriate stage of synthesis by hydrogenolysis of the labile carbon-oxygen bond:



C. L. A. Schmidt, The Chemistry of the Amino Acids and Proteins (Thomas, Springfield, IL, 1944) p 262; S. Archer in Amino Acids and Proteins, D. M. Greenberg, Ed. (Charles C. Thomas, Springfield, IL, 1951) p 177; G. W. Kenner, J. Chem. Soc. 1956, 3689; T. W. Greene, Protective Groups in Organic Synthesis (Wiley, New York, 1981) p 239, Cf. Fischer Peptide Synthesis.