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Difluorochloromethane

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Name

Difluorochloromethane

EINECS 200-871-9
CAS No. 75-45-6 Density 1.277 g/cm3
PSA 0.00000 LogP 1.44780
Solubility slightly soluble in water Melting Point -146 °C
Formula CHClF2 Boiling Point -40.8 °C
Molecular Weight 86.47 Flash Point
Transport Information UN 1018 Appearance Colourless gas
Safety 23-59 Risk Codes 40-59
Molecular Structure Molecular Structure of 75-45-6 (Methane,chlorodifluoro-) Hazard Symbols FlammableF
Synonyms

Algeon 22;Algofrene 22;Algofrene 6;Arcton 22;Arcton 4;CFC 22;Chlorodifluoromethane;Daiflon 22;Difluoromonochloromethane;Dymel 22;F 22 (halocarbon);FC 22;FC 22 (halocarbon);FKW 22;Flugene22;Forane 22;Freon 22;Frigen 22;Fron 22;HFA 22;Haltron 22;Isceon 22;Isotron 22;Khladon 22;Korfron 22;Propellant 22;Refrigerant R 22;Solkane 22;Ucon 22;

 

Difluorochloromethane Synthetic route

chlorodifluoromethyllithium

75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol In N,N,N,N,N,N-hexamethylphosphoric triamide decompn. in the presence of CF3CH2OH at reflux temp., 12 h;100%
In N,N,N,N,N,N-hexamethylphosphoric triamide
75-09-2

dichloromethane

7664-41-7

ammonia

A

74-90-8

hydrogen cyanide

B

75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
nickel In neat (no solvent) steady-state flow reaction over Ni catalyst at 723 K;A 98.3%
B 0.6%
nickel In neat (no solvent) steady-state flow reaction over Ni catalyst at 673 K;A 75.4%
B 1.7%
79-53-8

chloropentafluoroacetone

A

75-45-6

Chlorodifluoromethane

B

354-34-7

trifluoroacetyl fluoride

C

2925-22-6

2,2-difluoroacetyl fluoride

D

152239-89-9

C3HClF6O

Conditions
ConditionsYield
With chlorine monofluoride; cesium fluoride 1.) -140 degC to -75 degC over 6 h, 2.) -75 degC, 2 h; Further byproducts given;A n/a
B n/a
C n/a
D 90%
75-09-2

dichloromethane

7664-41-7

ammonia

A

74-90-8

hydrogen cyanide

B

75-10-5

Difluoromethane

C

75-45-6

Chlorodifluoromethane

D

124-38-9

carbon dioxide

E

201230-82-2

carbon monoxide

Conditions
ConditionsYield
nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 773 K, further by-product is CFH3 (yield 0.3 %);A 81.8%
B 0.1%
C 0.6%
D 10.4%
E 6.8%
nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 823 K, further by-product is CFH3 (yield 0.4 %);A 66.2%
B 0.2%
C 1.4%
D 12.9%
E 18.8%
With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 821 K, a further by-product is CFH3 (yield 0.2 %);A 64.6%
B 0.3%
C 0.2%
D 0.6%
E 0.8%
1895-39-2

sodium chlorodifluoroacetate

75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃;68%
75-09-2

dichloromethane

7664-41-7

ammonia

A

74-90-8

hydrogen cyanide

B

593-53-3

Methyl fluoride

C

75-10-5

Difluoromethane

D

75-45-6

Chlorodifluoromethane

E

124-38-9

carbon dioxide

Conditions
ConditionsYield
With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 769 K;A 53.4%
B 0.3%
C 0.5%
D 7.6%
E 0.5%
1717-59-5

2,2-difluoro-2-(fluorosulfonyl)acetic acid

1005-30-7

sodium 4-iodo-benzoate

A

75-45-6

Chlorodifluoromethane

B

120608-87-9

4-Iodo-benzoic acid difluoromethyl ester

Conditions
ConditionsYield
With potassium chloride In acetonitrile at 50℃; for 2.5h;A n/a
B 45%
79-38-9

Chlorotrifluoroethylene

152239-89-9

C3HClF6O

A

75-45-6

Chlorodifluoromethane

B

354-34-7

trifluoroacetyl fluoride

C

2925-22-6

2,2-difluoroacetyl fluoride

D

2-(2,2-Dichloro-1,1,2-trifluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

Conditions
ConditionsYield
In trichlorofluoromethane for 18h; -135 degC to 25 degC; Further byproducts given;A n/a
B n/a
C n/a
D 40%
420-49-5

chlorodifluoroiodomethane

potassium hydroxide

A

75-45-6

Chlorodifluoromethane

B

584-08-7

potassium carbonate

Conditions
ConditionsYield
In ethanol decompn. with alc. KOH at 35°C in 48h;;A 24%
B n/a
In ethanol
75-43-4

Dichlorofluoromethane

1188-14-3

Triethylgerman

A

75-10-5

Difluoromethane

B

75-09-2

dichloromethane

C

75-46-7

trifluoromethan

D

75-45-6

Chlorodifluoromethane

E

994-28-5

triethylchlorogermane

Conditions
ConditionsYield
With ACF. Et3GeH at 25℃; for 72h; Schlenk technique; Inert atmosphere;A n/a
B n/a
C 22%
D 16%
E n/a
34557-54-5

methane

75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With chromium fluoride; hydrogen fluoride; chlorine at 275 - 300℃;
75-10-5

Difluoromethane

75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With chlorine
75-09-2

dichloromethane

75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With hydrogen fluoride; lithium fluoride Electrolysis;
75-43-4

Dichlorofluoromethane

75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With aluminium trichloride Siedetemperatur;
67-66-3

chloroform

75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With hydrogen fluoride; antimonypentachloride at 80℃;
With calcium fluoride; silver fluoride at 250℃;
With antimony(III) fluoride
75-71-8

Dichlorodifluoromethane

75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With hydrogen; platinum at 685℃;
With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃;
With hydrogen Heating;
116-15-4

perfluoropropylene

A

116-14-3

polytetrafluoroethylene

B

75-45-6

Chlorodifluoromethane

C

76-16-4

Hexafluoroethane

Conditions
ConditionsYield
Ambient temperature; Irradiation; also CF2HCl;
75-09-2

dichloromethane

A

75-10-5

Difluoromethane

C

75-45-6

Chlorodifluoromethane

D

75-43-4

Dichlorofluoromethane

E

75-71-8

Dichlorodifluoromethane

F

75-69-4

trichlorofluoromethane

Conditions
ConditionsYield
With xenon difluoride for 48h; Ambient temperature; other halogenocarbons; var. reaction time;
75-43-4

Dichlorofluoromethane

A

75-09-2

dichloromethane

B

75-45-6

Chlorodifluoromethane

C

67-66-3

chloroform

Conditions
ConditionsYield
With silica gel at 149.9℃; for 6h; Product distribution;
75-43-4

Dichlorofluoromethane

A

75-46-7

trifluoromethan

B

75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With antimony tetrachloride fluoride at 100℃; Kinetics; kinetic batch run;
75-43-4

Dichlorofluoromethane

A

75-46-7

trifluoromethan

B

75-45-6

Chlorodifluoromethane

C

67-66-3

chloroform

Conditions
ConditionsYield
zinc aluminate at 250℃; Product distribution; other temperature;
67-66-3

chloroform

A

75-46-7

trifluoromethan

B

75-45-6

Chlorodifluoromethane

C

75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With antimony tetrachloride fluoride at 100℃; Kinetics; Product distribution; kinetic behaviour of different fluorinated antimony compound in fluorination (SbCl4F, SbCl5 + SbF3Cl2, SbCl5 + SbF5, SbCl5 + SbF3) at different reaction times;
With antimony tetrachloride fluoride at 100℃; under 7600 Torr; Kinetics; Product distribution; Equilibrium constant; kinetic at three different temperatures (85, 100, 115 deg C) and at different pressures ( 7.3, 8.0, 10.0, 10.5, 13.0, 13.8 atm);
With hydrogen fluoride; antimonypentachloride at 70 - 90℃; under 10746.4 - 10953.3 Torr; Product distribution / selectivity; Heating / reflux;
75-71-8

Dichlorodifluoromethane

A

74-90-8

hydrogen cyanide

B

593-53-3

Methyl fluoride

C

75-10-5

Difluoromethane

D

75-45-6

Chlorodifluoromethane

E

124-38-9

carbon dioxide

F

201230-82-2

carbon monoxide

Conditions
ConditionsYield
With O3Ti(2-)*Ni(2+); ammonia at 499.9℃; Product distribution; other catalysts;
353-59-3

halon-1211

75-45-6

Chlorodifluoromethane

Conditions
ConditionsYield
With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃;
With bromine at 349.9℃; Equilibrium constant; different reagent and reactant concentrations and reaction temperatures;
353-59-3

halon-1211

A

1511-62-2

bromodifluoromethane

B

75-10-5

Difluoromethane

C

373-52-4

bromofluoromethane

D

75-09-2

dichloromethane

E

75-45-6

Chlorodifluoromethane

F

74-95-3

1,2-dibromomethane

Conditions
ConditionsYield
With hydrogen In gas at 400 - 900℃; under 760 Torr; Rate constant; Product distribution; Mechanism; other reagents; Ea;
75-38-7

Vinylidene fluoride

152239-89-9

C3HClF6O

A

75-45-6

Chlorodifluoromethane

B

354-34-7

trifluoroacetyl fluoride

C

2-(2-Chloro-1,1-difluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

D

2-(2-Chloro-2,2-difluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

Conditions
ConditionsYield
In trichlorofluoromethane for 24h; -141 degC to 25 degC; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
116-14-3

polytetrafluoroethylene

A

75-45-6

Chlorodifluoromethane

B

354-25-6

2-chloro-1,1,2,2-tetrafluoroethane

C

2837-89-0

1,1,1,2-tetrafluoro-2-chloroethane

D

115-25-3

Octafluorocyclobutane

Conditions
ConditionsYield
With hydrogenchloride at 660℃; under 760 Torr; Mechanism; Ar-diluted mixtures, flow conditions; other temperatures;
79-38-9

Chlorotrifluoroethylene

152239-93-5

C3HCl2F5O

A

75-45-6

Chlorodifluoromethane

B

354-27-8

chlorodifluoroacetyl fluoride

C

1-Chloro-2-(1,2-dichloro-1,2,2-trifluoro-ethoxy)-1,1,2,3,3-pentafluoro-propane

D

1-Chloro-2-(2,2-dichloro-1,1,2-trifluoro-ethoxy)-1,1,2,3,3-pentafluoro-propane

Conditions
ConditionsYield
In trichlorofluoromethane for 18h; -136 degC to 20 degC; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
75-09-2

dichloromethane

A

75-10-5

Difluoromethane

C

75-45-6

Chlorodifluoromethane

D

75-43-4

Dichlorofluoromethane

E

75-71-8

Dichlorodifluoromethane

Conditions
ConditionsYield
With osmium pentafluoride oxide Product distribution; other transition-metal oxide fluorides;
75-71-8

Dichlorodifluoromethane

812-15-7

1,1,1,2,2-pentamethyldisilane

A

75-77-4

chloro-trimethyl-silane

B

993-07-7

trimethylsilan

C

75-45-6

Chlorodifluoromethane

D

1560-28-7

pentamethylchlorodisilane

E

75-78-5

dimethylsilicon dichloride

Conditions
ConditionsYield
at 436.9 - 492.9℃; under 1.5 - 3 Torr; Product distribution; Thermodynamic data; other temp.;

2-[2-(5-bromo-2-hydroxyphenyl)-ethyl]-3-chlorobenzonitrile

75-45-6

Chlorodifluoromethane

2-[2-(5-bromo-2-difluoromethoxyphenyl)-ethyl]-3-chlorobenzonitrile

Conditions
ConditionsYield
With potassium hydroxide In isopropyl alcohol at 20 - 65℃; for 1.1h;100%
75-45-6

Chlorodifluoromethane

944334-01-4

4-bromo-2-vinyloxy-1-methoxybenzene

944333-99-7

4-bromo-2-cyclopropoxy-1-methoxybenzene

Conditions
ConditionsYield
With dimethyl zinc(II) In toluene at -40 - 20℃; for 28.25h;100%
75-45-6

Chlorodifluoromethane

140675-43-0

2-Fluoro-6-hydroxybenzonitrile

221202-14-8

2-(difluoromethoxy)-6-fluorobenzonitrile

Conditions
ConditionsYield
With sodium hydroxide In diethylene glycol dimethyl ether; water at 20 - 65℃;99%
Stage #1: 2-Fluoro-6-hydroxybenzonitrile With sodium hydroxide In 1,2-dimethoxyethane; water at 65℃;
Stage #2: Chlorodifluoromethane In 1,2-dimethoxyethane; water at 20 - 65℃;
With sodium hydroxide In 1,4-dioxane; water at 65℃;
75-45-6

Chlorodifluoromethane

(1-Benzyloxymethyl-prop-2-ynyloxy)-tert-butyl-dimethyl-silane

(1-Benzyloxymethyl-4,4-difluoro-but-2-ynyloxy)-tert-butyl-dimethyl-silane

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran 1.) -78 deg C, 30 min, 2.) -78 deg C, 1 h;98%
645-00-1

m-iodonitrobenzene

75-45-6

Chlorodifluoromethane

98-46-4

3-trifluoromethylnitrobenzene

Conditions
ConditionsYield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 5h; Mechanism; Sealed tube; Inert atmosphere;98%
75-45-6

Chlorodifluoromethane

66225-40-9

N-ethyl-N-methylbutan-1-amine

N-butyl-N-(difluoromethyl)-N-methylammonium nitrate

Conditions
ConditionsYield
With sodium hydroxide; sodium nitrate In tetrahydrofuran; water at 20℃;97%
75-45-6

Chlorodifluoromethane

144432-79-1

4-biphenylboronic acid 1,2-ethanediol ester

4-phenyl-α,α-difluorotoluene

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone In 1,4-dioxane at 110℃; for 48h; Schlenk technique; Inert atmosphere;97%
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 48h; Inert atmosphere; Sealed tube;95%

5-methyl-2-phenyl-1,2,4-triazolidin-3-one

75-45-6

Chlorodifluoromethane

4,5-dihydro-3-methyl-4-difluoromethyl-1-(2,4-dichlorophenyl)-1,2,4-triazol-5(1H)-one

Conditions
ConditionsYield
Stage #1: 5-methyl-2-phenyl-1,2,4-triazolidin-3-one With chlorine In water; 1,2-dichloro-ethane at 20 - 80℃; for 5.36h; Molecular sieve;
Stage #2: With potassium carbonate In 5,5-dimethyl-1,3-cyclohexadiene; Triethylene glycol dimethyl ether at 140℃; for 4h;
Stage #3: Chlorodifluoromethane In 5,5-dimethyl-1,3-cyclohexadiene; Triethylene glycol dimethyl ether at 185℃; for 0.5h;
96.1%
75-45-6

Chlorodifluoromethane

651-84-3

4-trifluoromethyl-2,3,5,6-tetrafluorothiophenol

1-Difluoromethylsulfanyl-2,3,5,6-tetrafluoro-4-trifluoromethyl-benzene

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane; water at 45℃; for 3h;96%
67249-20-1

1-decylpiperidine

75-45-6

Chlorodifluoromethane

N-decyl-N-(difluoromethyl)piperidinium chloride

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 3.5h;96%
102-82-9

tributyl-amine

75-45-6

Chlorodifluoromethane

N,N,N-tributyl-N-(difluoromethyl)ammonium chloride

Conditions
ConditionsYield
Stage #1: tributyl-amine With sodium hydroxide In tetrahydrofuran; water at 20℃; for 0.0333333h;
Stage #2: Chlorodifluoromethane In tetrahydrofuran; water
96%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 3h;92%
75-45-6

Chlorodifluoromethane

K(1+)*C14H14BO3(1-)

4-phenyl-α,α-difluorotoluene

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone In 1,4-dioxane at 110℃; for 48h; Schlenk technique; Inert atmosphere;96%
75-45-6

Chlorodifluoromethane

116-14-3

polytetrafluoroethylene

Conditions
ConditionsYield
With high nickel alloy at 420 - 955℃; for 6.94444E-05h; Temperature;95.2%
In gas Product distribution; Irradiation; dependence on pressure and light intensity;
Pyrolysis;
37622-90-5

4-ethoxycarbonylpyrazole

75-45-6

Chlorodifluoromethane

129819-40-5

ethyl 1-(difluoromethyl)-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 2h;95%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 130 - 140℃; for 3h;41%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 130 - 140℃; for 3h;41%
75-45-6

Chlorodifluoromethane

123-08-0

4-hydroxy-benzaldehyde

73960-07-3

4-difluoromethoxybenzaldehyde

Conditions
ConditionsYield
Stage #1: 4-hydroxy-benzaldehyde With sodium hydroxide; 18-crown-6 ether In water; isopropyl alcohol for 0.5h;
Stage #2: Chlorodifluoromethane In water; isopropyl alcohol at 65℃; for 5 - 6h;
95%
With sodium hydroxide; sodium dithionite In 1,4-dioxane; water at 65 - 70℃; for 5h;76%
With sodium hydroxide; Tris(3,6-dioxaheptyl)amine In toluene at 105℃; for 1.17h;24%
75-45-6

Chlorodifluoromethane

68-34-8

phenyl toluenesulfonamide

N-(difluoromethyl)-4-methyl-N-phenylbenzenesulfonamide

Conditions
ConditionsYield
With potassium hydroxide In N,N-dimethyl-formamide at 60 - 70℃;95%

C10H21N(CH3)C2H5

75-45-6

Chlorodifluoromethane

N-decyl-N-(difluoromethyl)-N-ethyl-N-methylammonium chloride

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 2h;95%
120-03-6

2-(p-tolyl)-1H-benzimidazole

75-45-6

Chlorodifluoromethane

1309978-33-3

1-(difluoromethyl)-2-(4-methylphenyl)-1H-benzimidazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90℃;95%
636-98-6

p-nitrobenzene iodide

75-45-6

Chlorodifluoromethane

402-54-0

p-nitrobenzotrifluoride

Conditions
ConditionsYield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 5h; Mechanism; Sealed tube; Inert atmosphere;95%
75-45-6

Chlorodifluoromethane

13922-41-3

1-Naphthylboronic acid

53731-26-3

1-(difluoromethyl)naphthalene

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 48h; Inert atmosphere; Sealed tube;95%
75-45-6

Chlorodifluoromethane

60134-93-2

3-(tert-butyldimethylsilyloxy)oct-1-yne

183996-60-3

tert-Butyl-[1-(3,3-difluoro-prop-1-ynyl)-hexyloxy]-dimethyl-silane

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran 1.) -78 deg C, 30 min, 2.) -78 deg C, 1 h;94%
866130-43-0

4-(5-hydroxy-3-trifluoromethyl-pyrazol-1-yl)-benzoic acid ethyl ester

75-45-6

Chlorodifluoromethane

866130-44-1

4-(5-difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzoic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at -78 - 100℃; for 12h;94%
75-45-6

Chlorodifluoromethane

66-99-9

β-naphthaldehyde

131581-40-3

1,1-difluoro-2-(2-naphthyl)ethene

Conditions
ConditionsYield
With tetrabutyl-ammonium chloride; triphenylphosphine; methyloxirane In N,N-dimethyl-formamide at 110℃; for 6h; Wittig Olefination; Sealed tube; Molecular sieve; Inert atmosphere;94%
75-45-6

Chlorodifluoromethane

90-14-2

1-Iodonaphthalene

26458-04-8

1-trifluoromethylnaphthalene

Conditions
ConditionsYield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 5h; Mechanism; Sealed tube; Inert atmosphere;94%
75-45-6

Chlorodifluoromethane

K(1+)*C18H22BO3(1-)

4-phenyl-α,α-difluorotoluene

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone In 1,4-dioxane at 110℃; for 48h; Schlenk technique; Inert atmosphere;94%
75-45-6

Chlorodifluoromethane

tetrabutylammonium 7-acetylspiro[1,3-benzodioxole-2,4'-tetrahydrothiopyran]-4-olate

1-[7-(difluoromethoxy)spiro[1,3-benzodioxole-2,4'-tetrahydrothiopyran]-4-yl]ethanone

Conditions
ConditionsYield
Stage #1: Chlorodifluoromethane; tetrabutylammonium 7-acetylspiro[1,3-benzodioxole-2,4'-tetrahydrothiopyran]-4-olate In N,N-dimethyl-formamide at 50 - 55℃; Large scale;
Stage #2: With water; sodium hydroxide In N,N-dimethyl-formamide at 45 - 55℃; Large scale;
94%
75-45-6

Chlorodifluoromethane

C25H23ClN2O3

C26H24F2N2O3

Conditions
ConditionsYield
With dmap; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; nickel dichloride; zinc In N,N-dimethyl acetamide at 60℃; for 12h; Molecular sieve;94%
75-45-6

Chlorodifluoromethane

C11H6BrF3

2-(3-bromophenyl)-3-((difluoromethyl)selanyl)-4-(trifluoromethyl)selenophene

Conditions
ConditionsYield
With selenium; water; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 10h; Schlenk technique; Inert atmosphere; regioselective reaction;94%

Difluorochloromethane Chemical Properties

Molecular Formula: CHClF2
Molecular Weight: 86.47
EINECS: 200-871-9 
Index of Refraction: 1.278
Density: 1.277 g/cm3
Melting point: -146 °C
Boiling Point: 155 °C
Water solubility: Slightly soluble
Appearance: Colourless gas
Structure of Difluorochloromethane (CAS NO.75-45-6):
                      
IUPAC Name: Chloro(difluoro)methane
Product Category of Difluorochloromethane (CAS NO.75-45-6): refrigerants;Organics;Refrigerant

Difluorochloromethane Uses

 Difluorochloromethane (CAS NO.75-45-6) is mainly used as mainlyPropellant, fumigant, insecticide. It  was once commonly used as a propellant and in air conditioning applications.

Difluorochloromethane Production

 Difluorochloromethane (CAS NO.75-45-6) can be prepared from Chloroform : HCCl3 + 2HF → HCF2Cl + 2HCl .

Difluorochloromethane Toxicity Data With Reference

1.    

mmo-sat 33 pph/24H-C

    TOLED5    Toxicology Letters. 2 (1978),1.
2.    

mma-sat 33 pph/24H-C

    TOLED5    Toxicology Letters. 2 (1978),1.
3.    

ihl-rat LC50:35 pph/15M

    HUTODJ    Human Toxicology. 1 (1982),239.
4.    

ihl-mus LC50:28 pph/20M

    TXAPA9    Toxicology and Applied Pharmacology. 59 (1981),64.
5.    

ihl-dog LCLo:70 pph

    TXAPA9    Toxicology and Applied Pharmacology. 2 (1960),363.

Difluorochloromethane Consensus Reports

It is reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Difluorochloromethane Safety Profile

Hazard Codes: FlammableF
Risk Statements: 40-59 
R40:Limited evidence of a carcinogenic effect. 
R59:Dangerous to the ozone layer.
Safety Statements: 23-59 
S23:Do not breathe vapour. 
S59:Refer to manufacturer / supplier for information on recovery / recycling.
Mildly toxic by inhalation. Experimental reproductive effects. Mutation data reported. An asphyxiant in high concentrations. At elevated pressures, 50% mixtures with air are combustible although ignition is difficult. When heated to decomposition it emits toxic fumes of F and Cl.

Difluorochloromethane Standards and Recommendations

OSHA PEL: TWA 1000 ppm
ACGIH TLV: TWA 1000 ppm; Not Classifiable as a Human Carcinogen
DFG MAK: 500 ppm (1800 mg/m3)
DOT Classification:  2.2; Label: Nonflammable Gas

Difluorochloromethane Specification

 Difluorochloromethane , its cas register number is 75-45-6. It also can be called Chlorodifluoromethane ; Fluorocarbon 22 ; Freon R-22 ; and Freon 22 . Difluorochloromethane (CAS NO.75-45-6) is shipped as a liquefied gas under its own vapor pressure, and is noncombustible. Difluorochloromethane can asphyxiate by the displacement of air. Contact with the liquid can cause frostbite.

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