Chemical and Pharmaceutical Bulletin p. 1008 - 1026 (1997)
Update date:2022-08-03
Topics:
Inoue, Hirozumi
Konda, Mikihiko
Hashiyama, Tomiki
Otsuka, Hisao
Watanabe, Akishige
Gaino, Mitsunori
Takahashi, Kaoru
Date, Tadamasa
Okamura, Kimio
Takeda, Mikio
Narita, Hiroshi
Murata, Sakae
Odawara, Akio
Sasaki, Haruhiko
Nagao, Taku
2,3-Dihydro-1,5-benzothiazepin-4(5H)-ones substituted with an alkyl, alkoxy, alkylthio, hydroxy, or amino group on the fused benzene ring of the 1,5-benzothiazepine skeleton were synthesized and their vasodilating, antihypertensive, and platelet aggregation-inhibitory activities were investigated. (-)-cis-3-Acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-8- methyl-2-(4-methylphenyl)-1,5-benzothiazepin-4(5H)-one ((-)-13e) was selected for further studies as a potent inhibitor of platelet aggregation.
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(2013)
