Chemical and Pharmaceutical Bulletin p. 1008 - 1026 (1997)
Update date:2022-08-03
Topics:
Inoue, Hirozumi
Konda, Mikihiko
Hashiyama, Tomiki
Otsuka, Hisao
Watanabe, Akishige
Gaino, Mitsunori
Takahashi, Kaoru
Date, Tadamasa
Okamura, Kimio
Takeda, Mikio
Narita, Hiroshi
Murata, Sakae
Odawara, Akio
Sasaki, Haruhiko
Nagao, Taku
2,3-Dihydro-1,5-benzothiazepin-4(5H)-ones substituted with an alkyl, alkoxy, alkylthio, hydroxy, or amino group on the fused benzene ring of the 1,5-benzothiazepine skeleton were synthesized and their vasodilating, antihypertensive, and platelet aggregation-inhibitory activities were investigated. (-)-cis-3-Acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-8- methyl-2-(4-methylphenyl)-1,5-benzothiazepin-4(5H)-one ((-)-13e) was selected for further studies as a potent inhibitor of platelet aggregation.
View MoreContact:0086-22-2822 1962 / 2822 1963
Address:B-808, No. 1, North-South Street, Hexi District,
Contact:+86-28-88523492
Address:714rooms of Time Square, Pujiang County
Nanjing Raise Pharmatech Co., Ltd
website:http://www.raisechem.com
Contact:+86-25-58649566
Address:B381,No.606,Ningliu Road,Jiangbei New Area,Nanjing,Jiangsu Province,China
Shanghai Yuantai Chemical Products Co., Ltd
Contact:021--66129803
Address:Chengyin Road,Shanghai,China
Beijing Cooperate Pharmaceutical Co.,Ltd
website:http://www.cooperate-pharm.com/
Contact:86-01060279497
Address:No.507,Building 4,Tianhua Street, Biomedicine industrial Base
Doi:10.1021/jo9911084
(1999)Doi:10.1016/S0040-4039(96)02420-3
(1997)Doi:10.1021/ja00730a022
(1971)Doi:10.1016/S0957-4166(99)00299-2
(1999)Doi:10.1016/S0960-894X(99)00463-1
(1999)Doi:10.1039/c3ob40979a
(2013)
