Application of organolithium and related reagents in synthesis. Part XI. Metallation of 2-methyl- and 4-methylnicotinic acids. A useful method for preparation of aza-isocoumarins

Article abstract of DOI:10.1080/00397919208019305

The metallation (LDA/THF) of 2-methyl- and 4-methylnicotinic acids (1) and (2), and the subsequent reaction of the lithiated species (3) and (4) with carbonyl electrophiles as a synthetic route of 5-aza- and 7-aza-isocoumarins (7), (8), (9) and (10), is d

Full text of DOI:10.1080/00397919208019305

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Synthetic Communications: An
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Organic Chemistry
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Application of Organolithium
and Related Reagents
in Synthesis. Part 111.
Metallation of 2-Methyl- and 4-
Methylnicotinic Acids. A Useful
Method for Preparation of AZA-
Isocoumarins
J. Epsztajn a , M. W. Płotka a & J. Ścianowski a
a Department of Organic Chemistry , Institute of
Chemistry, University , 90-136, Łódź, Narutowicza,
68, Poland
Published online: 24 Sep 2006.
To cite this article: J. Epsztajn , M. W. Płotka & J. Ścianowski (1992) Application of
Organolithium and Related Reagents in Synthesis. Part 111. Metallation of 2-Methyl-
and 4-Methylnicotinic Acids. A Useful Method for Preparation of AZA-Isocoumarins,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 22:9, 1239-1247, DOI: 10.1080/00397919208019305
To link to this article: http://dx.doi.org/10.1080/00397919208019305
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