Diethyl 3,6-Dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11-dicarboxylates as Calcium Entry Antagonists: New Conformationally Restrained Analogues of Hantzsch 1,4-Dihydropyridines Related to Nitrendipine as Probes for Receptor-Site Conformation

DOI: 10.1021/jm00387a019

Source and publish data:

Journal of Medicinal Chemistry p. 690 - 695 (1987)

Update date:2022-07-29

Topics:

Authors:

Baldwin, John J.

Claremon, David A.

Lumma, Patricia K.

McClure, David E.

Rosenthal, Seth A.

et al. et al.

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Article abstract of DOI:10.1021/jm00387a019

The pharmacological activity of rigid analogues of 1,4-dihydropyridine calcium entry antagonists 9-16 is demonstrated by dose-dependent inhibition of the calcium concentration in depolarized rat aortic strips and by a <3H>nitrendipine binding assay in usi

Full text of DOI:10.1021/jm00387a019

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