
Journal of Medicinal Chemistry p. 2059 - 2070 (1994)
Update date:2022-09-26
Topics: Acetic acid N-Substituted Aldose reductase inhibitors
Malamas
Hohman
The isoquinoline-1,3-dione framework featured in our clinical candidate (1) and its congener was used as the template in the design of several new series of aldose reductase inhibitors (ARIs). These series included N'- substituted spirosuccinimide, spirop
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Doi:10.1007/BF00763529
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(1987)