Diastereoselective addition of organolithiums to new chiral hydrazones. Enantioselective synthesis of (R)-coniine

Article abstract of DOI:10.1016/0040-4039(96)01151-3

The reactions of organolithiums with the new chiral hydrazones derived from (S)-indoline-2-carboxylic acid afforded chiral hydrazines with high diastereoselectivities (up to 99% de) and the present method was utilized for the preparation of high optically pure (R)-coniine (94% ee).