Journal of Medicinal Chemistry p. 3073 - 3076 (2008)
Update date:2022-07-30
Topics:
Tassoni, Emanuela
Giannessi, Fabio
Brunetti, Tiziana
Pessotto, Pompeo
Renzulli, Michela
Travagli, Massimiliano
Rajam?ki, Suvi
Prati, Samanta
Dottori, Secondo
Corelli, Federico
Cabri, Walter
Carminati, Paolo
Botta, Maurizio
We report the synthesis and evaluation of aminoalkylguanidine analogues and derivatives in C57BL/KsJ db/db diabetic mice, following identification by random screening of 1a and 1b as potential antihyperglycemics and/or modulators of food intake. These compounds are related to galegine, a γ,γ- dimethylallylguanidine. Between the newly identified compounds, 1h N-(cyclopropylmethyl)-N′-(4-(aminomethyl)-cyclohexylmethyl)guanidine showed the most balanced activity as antihyperglycemic and food intake-reducing agent.
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