Synthesis of β-Carboline-Benzodiazepine Hybrid Molecules: Use of the Known Structural Requirements for Benzodiazepine and β-Carboline Binding in Designing a Novel, High-Affinity Ligand for the Benzodiazepine Receptor

DOI: 10.1021/jm00390a023

Source and publish data:

Journal of Medicinal Chemistry p. 1248 - 1254 (1987)

Update date:2022-08-05

Topics:

Authors:

Dodd, Robert H.

Ouannes, Catherine

Potier, Marie-Claude

Carvalho, Lia Prado de

Rossier, Jean

Potier, Pierre

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Article abstract of DOI:10.1021/jm00390a023

Hybrid molecules incorporating pharmacologically important structural features of both 3-carboxy-β-carbolines and 1,4-benzodiazepines were synthesized, and their affinities for the benzodiazepine receptor were determined in vitro.One of this hybrids, 8,14

Full text of DOI:10.1021/jm00390a023

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