GABA Agonists and Uptake Inhibitors. Synthesis, Absolute Stereochemistry, and Enantioselectivity of (R)-(-)- and (S)-(+)-Homo-β-proline

Article abstract of DOI:10.1021/jm00163a012

The cyclic analogue of 4-aminobutyric acid (GABA), 3-pyrrolidineacetic acid (homo-β-proline), is a potent agonist at GABA_A receptors, it interacts effectively with GABA-uptake mechanisms, and it is a moderately potent inhibitor of GABA_B