Total Synthesis of (-)-Denticulatins A and B: Marine Polypropionates from Siphonaria denticulata

Article abstract of DOI:10.1021/jo00296a044

A synthesis of the marine polypropionates (-)-denticulatin A (2a) and B (2b) is described.The targets, which are β-hydroxy ketones wherein the hydroxyl group is also a tertiary hemiketal, are sensitive to acid dehydration.An open chain form (26) of the de