A SHORT STEP SYNTHESIS OF CLAVICIPITIC ACIDS FROM 4-CYANOMETHYLINDOLE

Article abstract of DOI:10.3987/R-1987-05-1197

4-(3-methyl-1-oxo-2-buten-1-yl)indole (3) was efficiently synthesized from 4-cyanomethyl-1-(p-toluenesulfonyl)indole by alkylation with 2-methyl-2-buten-1-yl tosylate and by successive aerobic oxidation and deprotection of N-tosyl group.The acylindole 3 was used for a short step synthesis of clavicipitic acids (4).