Diisopropylsilyl-linked oligonucleotide analogs: Solid-phase synthesis and physicochemical properties

Article abstract of DOI:10.1021/jo00079a030

A novel synthetic method has been developed for efficient preparation of silyl-linked oligodeoxyribonucleotide analogs. The method allows, for the first time, automated solid-phase synthesis of long oligomers uniformly linked with the silyl internucleosid