Journal of Organic Chemistry p. 640 - 643 (1989)
Update date:2022-07-30
Topics:
Houminer, Y.
Southwick, E. W.
Williams, D. L.
The homolytic acylation of various monosubstituted pyrazines was studied for a wide spectrum of substituents.Methoxy and chloro substituents were found to direct ortho substitution, thus giving the corresponding 2,3-disubstituted pyrazines.Acetyl, carbethoxy, and carboxamide groups were found to direct para substitution, thus leading to the corresponding 2,5-disubstituted pyrazines.These selectivities result from the combination of the inductive and resonance effects of the substituents.The synthetic potential of the acylation reaction is demonstrated in the preparation of some novel pyrazine flavorants.
View MoreShanghai Mintchem Development ., Ltd
Contact:0086 21 5190 8570
Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China
SHIFANG SUHONG CHEMICAL CO.,LTD
Contact:+86-838-2224563
Address:Room 1207 Zongchen Sunshine No.128 Taishan South Road,Deyang City,Sichuan China
Contact:+86-15850770348
Address:51 OF XIANGFANGCUN ROAD, Nanjing 210002, China
Shanghai Yudiao Chemistry Technology Co.,Ltd
Contact:0086-18964703211
Address:Building NO.5, NO.218,Rongtian Road,ganxiang town,Jinshan District,shanghai,201518,china
Zibo Widespread International Business Co.,Ltd
Contact:+86-533-5187258
Address:Room 1012, No. 2 flat of Hongtai Building, Songling East Road, Zichuan, Zibo, Shandong, China
Doi:10.1021/ja9049228
(2009)Doi:10.1016/S0040-4039(00)80407-4
(1988)Doi:10.1016/j.molcatb.2012.11.006
(2013)Doi:10.1002/anie.202017190
(2021)Doi:10.1139/V06-065
(2006)Doi:10.1016/j.bmcl.2009.11.040
(2010)
