Tetrahedron p. 2273 - 2276 (2010)
Update date:2022-08-04
Topics:
Bernotas, Ronald C.
Dooley, Rebecca J.
Expeditious routes to 1,2,3,4,4a,5-hexahydro-pyrazino[2,1-c][1,4]benzothiazine-6,6-dioxide, a methylenesulfone-constrained arylpiperazine, have been developed. The key step forms the tricyclic system in a cascade of reactions via a 1,4-addition, nitrogen alkylation, and aromatic substitution sequence.
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(2010)
