Journal of the American Chemical Society p. 6257 - 6265 (1989)
Update date:2022-07-29
Topics:
Horiguchi, Yoshiaki
Nakamura, Eiichi
Kuwajima, Isao
Total syntheses of (+/-)-cortisone and (+/-)-adrenosterone have been achieved in 18 steps with the aid of metal-assisted new synthetic sequences in particular, ene reaction and homoenolate chemistry.A novel double-hydroxylation reaction of enol silyl ethers leading to a single step construction of the dihydroxyacetone side chain in corticoids has been developed and applied to the synthesis of cortisone, cortexolone, and 16α-methylcortexolone.
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