Colchicine Models: Synthesis and Antitubulin Activity of 2'-Monosubstituted and 2',5-Disubstituted 2,3,4,4'-Tetramethoxy-1,1'-biphenyls. Synthesis of 4,4',5',6'-Tetramethoxy-1,1'-biphenyl-2,3'-dicarboxylic Acid

DOI: 10.1002/hlca.19890720203

Source and publish data:

Helvetica Chimica Acta p. 196 - 204 (1989)

Update date:2022-09-26

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Authors:

Itoh, Yoshikuni

Brossi, Arnold

Hamel, Ernest

Flippen-Anderson, Judith L.

George, Clifford

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Article abstract of DOI:10.1002/hlca.19890720203

Reductive amination of 2,3,4,4'-tetramethoxybiphenyl-2-carbaldehyde (4) with MeNH2 afforded methylamine 5 (Scheme 1).Hydroxymethylation of amine 8, prepared similarly from 4 by reductive amination with benzylamine followed by N-methylation, afforded alcoh

Full text of DOI:10.1002/hlca.19890720203

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