Colchicine Models: Synthesis and Antitubulin Activity of 2'-Monosubstituted and 2',5-Disubstituted 2,3,4,4'-Tetramethoxy-1,1'-biphenyls. Synthesis of 4,4',5',6'-Tetramethoxy-1,1'-biphenyl-2,3'-dicarboxylic Acid

Article abstract of DOI:10.1002/hlca.19890720203

Reductive amination of 2,3,4,4'-tetramethoxybiphenyl-2-carbaldehyde (4) with MeNH2 afforded methylamine 5 (Scheme 1).Hydroxymethylation of amine 8, prepared similarly from 4 by reductive amination with benzylamine followed by N-methylation, afforded alcoh