Methodology for the Enantioselective Synthesis of Aldols and Other 1,3-Dioxygenated Systems

Article abstract of DOI:10.1021/jo00292a008

The enantioselective synthesis of the spiroenones 3, 4 from (S)-glycidol-O-benzyl ether and lithiated furan derivatives is described.After conjugate addition of lithium dimethyl cuprate or lithium divinyl cuprate and conversion of the resulting saturated ketones to their respective iodides 7 and 8, fragmentation of these halides leads to the formation of acyclic aldol-containing carbon skeletons.