The synthesis of a γ-keto-α-amino acid, a key intermediate in the synthesis of monatin, a new natural sweetener

Article abstract of DOI:10.1080/00397919308012584

An efficient method was developed for the synthesis of the keto-amino acid 2, a key intermediate in the synthesis of the novel sweet compound, monatin 1. Preparation of 2 entails coupling of a suitably protected indole acetate anion to an aspartic acid derivative.

Full text of DOI:10.1080/00397919308012584

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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The Synthesis of a γ-Keto-α-
amino Acid, a Key Intermediate
in the Synthesis of Monatin, a
New Natural Sweetener
Cedric W. Holzapfel a & Johan Olivier b
a Department of Chemistry , Rand Afrikaans
University , Johannesburg, South Africa
b MATTEK, CSIR , P.O. Box 395, Pretoria, South Africa
Published online: 24 Sep 2006.
To cite this article: Cedric W. Holzapfel & Johan Olivier (1993) The Synthesis
of a γ-Keto-α-amino Acid, a Key Intermediate in the Synthesis of Monatin, a
New Natural Sweetener, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 23:18, 2511-2526, DOI:
10.1080/00397919308012584
To link to this article: http://dx.doi.org/10.1080/00397919308012584
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