Heterocycles p. 523 - 527 (1990)
Update date:2022-08-03
Topics:
Shiao, Min-Jen
Shyu, Li-Ming
Chen, Chieh-Fu
A new synthesis of milrinone (6) from 6-methyl-5-(4-pyridinyl)-2(1H)-pyridone (4) is reported.A convenient synthesis of 3,4'-bipyridines (3a) and (3b) is achieved. 3a and 3b can be converted into pyridone 4 by hydrogenolysis and hydrolysis, respectively.Bromination at C-3 of the pyridone ring of 4 followed by cyanation affords milrinone (6).
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Doi:10.1021/ja00983a023
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