Heterocycles p. 523 - 527 (1990)
Update date:2022-08-03
Topics:
Shiao, Min-Jen
Shyu, Li-Ming
Chen, Chieh-Fu
A new synthesis of milrinone (6) from 6-methyl-5-(4-pyridinyl)-2(1H)-pyridone (4) is reported.A convenient synthesis of 3,4'-bipyridines (3a) and (3b) is achieved. 3a and 3b can be converted into pyridone 4 by hydrogenolysis and hydrolysis, respectively.Bromination at C-3 of the pyridone ring of 4 followed by cyanation affords milrinone (6).
View MoreMTT Pharma & Bio-technology Co.,Ltd(expird)
Contact:+86-21-58407925
Address:Room2019, Building C, Tomson Center, No.158, Zhang Yang Road, Shanghai, China
Contact:+86-574-89075960
Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
Contact:+86-(0)21-3770 9035
Address:Room 301, Building 2, Meijiabang Road 1508, Shanghai China
Jiaxing Anrui Material Technology Co., Ltd.
Contact:86-573-82651652 13305832579
Address:Room 407, Technology Building, 1369 Chennan Road, Jiaxing City, Zhejiang, China
Contact:0027-717-456976
Address:2ND FLOOR, 325 VAUSE ROAD, OVERPORT, 4001, SOUTH AFRICA
Doi:10.1021/ja00983a023
(1967)Doi:10.1021/acs.joc.8b03002
(2019)Doi:10.7164/antibiotics.55.722
(2002)Doi:10.1039/c4ob00603h
(2014)Doi:10.1055/s-1994-25553
(1994)Doi:10.1016/j.ejmech.2019.111661
(2019)
