Synthesis and Cytotoxicity of Deoxyadenosine Analogues: Isomer Distribution in the Sodium Salt Glycosylation of 2,6-Disubstituted Purines

Article abstract of DOI:10.1021/jm00168a023

Several 2-substituted deoxyadenosine derivatives were synthesized and screened for cytotoxicity toward hematopoietic cells in culture.To prepare intermediates for these syntheses, the sodium salts of 2,6-dibromopurine and 2,6-bis(methylthio)purine were re