Synthesis of 1-methyl-5-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)uracil and 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)uracil. The C-nucleoside isostere of 3'-azido-3'-deoxythymidine and its 2'-'up'-fluoro analogue

DOI: 10.1021/jm00169a030

Source and publish data:

Journal of Medicinal Chemistry p. 1995 - 1999 (1990)

Update date:2022-08-05

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Authors:

Sochacka

Nawrot Nawrot

Pankiewicz

Watanabe

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Article abstract of DOI:10.1021/jm00169a030

1-Methyl-5-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)uracil (C-AZT), a C-nucleoside isostere of the potent anti-AIDS nucleoside 3'-azido-3'-deoxythymidine (AZT), was synthesized. 1-Methyl-2'-deoxy-5'-O-tritylpseudouridine (2a) was oxidized with CrO<

Full text of DOI:10.1021/jm00169a030

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