UN EQUIVALENT SYNTHETIQUE CHIRAL DU PRENAL, LE FORMYL-TRIMETHYLENEMETHANE(FER)TRICARBONYLE. SYNTHESE DU (R)-(-)-IPSDIENOL

Article abstract of DOI:10.1016/S0040-4039(00)70649-6

Formyl-TMM (Iron)tricarbonyl 3 reacts with a high diastereoselectivity with organozinc derivatives to Iron stabilized TMM-alcohols.These are decomplexed, under partial hydrogenation, by photolysis in acetic acid to give allylic and homoallylic isoprenoic alcohols.Starting from the optically active complex (+)-3, this allows a rapid synthesis of (R)-(-)-Ipsdienol of high ee.