Electroreductive cyclization reactions. Stereoselection, creation of quaternary centers in bicyclic frameworks, and a formal total synthesis of quadrone

Article abstract of DOI:10.1016/0040-4039(90)87014-Q

The electroreductive cyclization reaction has been successfully applied to an efficient formal total synthesis of quadrone (1). Two of the four rings were created electrochemically, a third via a novel oxidativedecarboxylation and cyclization onto a remote nitrile functional group (22a24).