Synthesis of batracylin and its N-sulfonamido analogues in [b-3C-im][NTf2] ionic liquid

DOI: 10.1016/j.tet.2014.02.076

Source and publish data:

Tetrahedron p. 2629 - 2633 (2014)

Update date:2022-08-04

Topics:

Authors:

Tseng, Ming-Chung

Lai, Peng-Yeh

Shi, Lin

Li, Hsin-Yi

Tseng, Min-Jen

Chu, Yen-Ho

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Article abstract of DOI:10.1016/j.tet.2014.02.076

Starting with commercial and inexpensive reagents, a high-yielding chemical process carried out in [b-3C-im][NTf₂] ionic liquid was achieved to afford the synthesis of batracylin and its N-sulfonamido analogues. Among all compounds synthesized, compounds 1, 11, and 14 exhibit potent inhibitory activity against human topoisomerase 1 (hTop1).

Full text of DOI:10.1016/j.tet.2014.02.076

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