Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors

DOI: 10.1021/jm00098a015

Source and publish data:

Journal of Medicinal Chemistry p. 3691 - 3698 (1992)

Update date:2022-07-29

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Authors:

Unangst Unangst

Shrum Shrum

Connor Connor

Dyer Dyer

Schrier Schrier

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Article abstract of DOI:10.1021/jm00098a015

A series of 1,2,4-oxadiazoles and 1,2,4-thiadiazoles containing a 2,6-di- tert-butylphenol substituent were prepared and evaluated as dual inhibitors of 5-lipoxygenase and cyclooxygenase in rat basophilic leukemia (RBL-1) cells. Several of these compounds

Full text of DOI:10.1021/jm00098a015

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