Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors

Article abstract of DOI:10.1021/jm00098a015

A series of 1,2,4-oxadiazoles and 1,2,4-thiadiazoles containing a 2,6-di- tert-butylphenol substituent were prepared and evaluated as dual inhibitors of 5-lipoxygenase and cyclooxygenase in rat basophilic leukemia (RBL-1) cells. Several of these compounds