Synthesis of a phosphonate isostere of ganciclovir monophosphate: A highly cytomegalovirus active phosphonate nucleotide analogue

DOI: 10.1016/S0040-4039(00)89037-1

Source and publish data:

Tetrahedron Letters p. 3257 - 3260 (1990)

Update date:2022-08-03

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Authors:

Kim Kim

Misco Misco

Luh Luh

Martin Martin

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Article abstract of DOI:10.1016/S0040-4039(00)89037-1

A novel synthetic methodology for the hydroxymethyl substituted acyclic acetal functionality was developed. The rationally designed phosphonate analogue 3 of ganciclovir monophosphate was highly active against human cytomegalovirus.

Full text of DOI:10.1016/S0040-4039(00)89037-1

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