Synthetic studies on the polyene macrolide antibiotics. Development of syn- and anti-1,3-diol subunits and assembly of the polyacetate region of amphotericin B

DOI: 10.1021/jo00129a019

Source and publish data:

Journal of Organic Chemistry p. 7778 - 7790 (1995)

Update date:2022-09-26

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Authors:

McGarvey

Mathys Mathys

Wilson Wilson

Overly Overly

Buonora Buonora

Spoors Spoors

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Article abstract of DOI:10.1021/jo00129a019

The synthesis of syn- and anti-1,3-diol subunits from thiol ester oxazoline 4 has been described. The key features of these synthetic sequences include the stereodivergent allylation of an asymmetric β-amino aldehyde (7) and the stereospecific transformat

Full text of DOI:10.1021/jo00129a019

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