Solid phase synthesis of a model nucleopeptide with a phosphodiester bond between the 5′ end of a trinucleotide and a serine residue

Article abstract of DOI:10.1016/S0040-4039(00)92178-6

The model nucleopeptide Boc-Ser(pTCT)-NHcHex has been assmbled on a polystyrene solid support using the phosphite triester approach. Fmoc and cyanoethyl groups have been used to protect the exocyclic amine of cytosine and phosphate groups respectively. Fi