A concise stereoselective synthesis of epibatidine employing conjugate addition to an alkenyl sulfone intermediate as the key step

DOI: 10.1055/s-1997-3225

Source and publish data:

Synlett p. 589 - 590 (1997)

Update date:2022-07-29

Topics:

Authors:

Giblin, Gerrard M. P.

Jones, Clifford D.

Simpkins, Nigel S.

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Article abstract of DOI:10.1055/s-1997-3225

A new synthesis of racemic epibatidine has been achieved, which involves conjugate addition of a metallated 2-methoxypyridine derivative to a suitably protected azabicyclic alkenyl sulfone as the key step.

Full text of DOI:10.1055/s-1997-3225

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