Novel Synthesis of (2S,3R,4S)-4-Amino-5-cyclohexyl-1-morpholino-2,3-pentanediol and (2S,3R,4S)-2-Amino-1-cyclohexyl-6-methyl-3,4-heptandiol, the C-Terminal Components of Renin Inhibitors

Article abstract of DOI:10.1246/cl.1990.1709

The title synthesis could be accomplished in a highly stereo-and regioselective manner by employing epoxide formation with inversion of configuration followed by epoxide opening with a nucleophile.