The active ester N-fmoc-3-O-[Ac4-α-D-Manp-(1→2)-Ac 3-α-D-Manp-1-]=thre-O-Pfp as a building block in solid-phase synthesis of an o-linked dimannosyl glycopeptide

Article abstract of DOI:10.1016/S0040-4039(00)97224-1

The active ester N^α-Fmoc-3-O-[Ac₄-α-D-Manp-(1→2)-Ac ₃-α-D-Manp-1-]-Thr-O-Pfp (6) was synthesized by direct condensation of Ac₄-α-D-Manp-(1→2)-Ac₃-α-D-Manp-Br (4) with Fmoc-Thr-O-Pfp (5) and used as a building block in an automated continuous-flow solid-phase synthesis of an O-glycosylated heptadeca amino acid fragment of the insulin-like growth factor 1 (IGF-1).