1-1-Dichloro-2,2,2-trifluoroethyllithium in asymmetric synthesis, II. A route to optically pure 4,4,4-trifluoro-2-hydroxybutanoic acid

Article abstract of DOI:10.1055/s-1991-26412

On addition of pre-cooled butyllithium to 1,1,1-trichloro-2,2,2-trifluoroethane (1) in diethyl ether at -125°C, 1,1-dichloro-2,2,2-trifluoroethyllithium (2) is formed, addition of o-substituted benzaldehydes yields 1-aryl-2,2-dichloro-3,3,3-trifluoropropa