A Highly Stereoselective Synthesis of (E)-Alkene Dipeptide Isosteres via Organocyanocopper-Lewis Acid Mediated Reaction

DOI: 10.1021/jo00014a010

Source and publish data:

Journal of Organic Chemistry p. 4370 - 4382 (1991)

Update date:2022-08-03

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Authors:

Ibuka, Toshiro

Habashita, Hiromu

Otaka, Akira

Fujii, Nobutaka

Oguchi, Yusaku

Uyehara, Tadao et al.

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Article abstract of DOI:10.1021/jo00014a010

A stereoselective synthesis of protected (E)-alkene dipeptide isosteres by the reaction of the mesylates of homochiral δ-aminated γ-hydroxy (E)-α,β-enoates with either RCu(CN)Li-BF3 or RCu(CN)MgX.BF3 reagent is described.The degree of diastereoselectivity

Full text of DOI:10.1021/jo00014a010

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