THE SYNTHESIS OF A FLUORINATED ANALOGUE OF 5-AMINOLAEVULINIC ACID, A POTENTIAL INHIBITOR OF PORPHYRIN BIOSYNTHESIS

Article abstract of DOI:10.1016/S0022-1139(00)80192-X

5-Amino-2-fluorolaevulinic acid 3 has been synthesized in high yield by modification of a new route to 5-aminolaevulinic acid (ALA), involving γ-lactone intermediates.Initial studies suggest that 3 is an inhibitor of ALA dehydratase, an early enzyme of tetrapyrrole biosynthesis.