Synthetic Studies toward Rapamycin: A Solution to a Problem in Chirality Merger through Use of the Ireland Reaction

DOI: 10.1021/jo00020a026

Source and publish data:

Journal of Organic Chemistry p. 5826 - 5834 (1991)

Update date:2022-07-30

Topics:

Authors:

Fisher, Matthew J.

Myers, Cheryl D.

Joglar, Jesus

Chen, Shu-Hui

Danishefsky, Samuel J.

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Article abstract of DOI:10.1021/jo00020a026

A program directed toward a total synthesis of rapamycin is described.This paper reports the synthesis of enoate 36, a fragment that would correspond to carbons 28-49 of rapamycin.The two building blocks required to reach 36 were allylic alcohol 5 and aci

Full text of DOI:10.1021/jo00020a026

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