Synthetic Studies toward Rapamycin: A Solution to a Problem in Chirality Merger through Use of the Ireland Reaction

DOI: 10.1021/jo00020a026

Source and publish data:

Journal of Organic Chemistry p. 5826 - 5834 (1991)

Update date:2022-07-30

Topics:

Authors:

Fisher, Matthew J.

Myers, Cheryl D.

Joglar, Jesus

Chen, Shu-Hui

Danishefsky, Samuel J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00020a026

A program directed toward a total synthesis of rapamycin is described.This paper reports the synthesis of enoate 36, a fragment that would correspond to carbons 28-49 of rapamycin.The two building blocks required to reach 36 were allylic alcohol 5 and aci

Full text of DOI:10.1021/jo00020a026

Products guided by the article

Product name:(R)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-pentanal

Cas No:135708-77-9

R&D Labs maybe for 135708-77-9

Changzhou Anyi Biochem Co., Ltd.(expird)

Contact:+86-519-88836158

Address:no,51 caoda
Changzhou LanXu Chemical Co.,ltd.(expird)

Contact:86-0519-86330911,13656129734,15261186386

Address:Room 524, Depart.Chemical, Changzhou Science and Eductaion town, Jiangsu, China;Factory: Haian Fine Chemical Industry Park,Nantong,Jiangsu,China
SICHUAN TONGSHENG AMINOACID CO.LTD

website:http://www.aminoacid.cc

Contact:86-838-2274206/2850606

Address:Room 1-11-1,No.19 of North TianShan Road,Deyang,Sichuan China
Sichuan WeiKeqi Biological Technology Co., Ltd.

website:https://www.weikeqi-biotech.com/en

Contact:86-028-81700200

Address:sichuan Chengdu Qingjiang Zhonglu 63号
Shenyang Xingzhenghe Chemical Co., Ltd.

Contact:024-23509232

Address:No. 33, Naner Road, Heping Dist.

Relevant to this article

Phenylhalosilazanes

Doi:10.1134/S1070363211120127
(2011)
Metal-free, visible-light-mediated direct C-H arylation of heteroarenes with aryl diazonium salts

Doi:10.1021/ja212099r
(2012)
Hydrogen-bond-mediated cascade reaction involving chalcones: Facile synthesis of enantioenriched trisubstituted tetrahydrothiophenes

Doi:10.1021/ol2034959
(2012)
The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer

Doi:10.1021/jm3005866
(2012)
A novel -d-galactosynthase from Thermotoga maritima converts -d-galactopyranosyl azide to -galacto-oligosaccharides

Doi:10.1093/glycob/cwq177
(2011)
Reaction of 2-hydroxy-1,2,2-triphenylethyl propionate with non-activated ketones and enones: Stereoselective aldol and Michael addition

Doi:10.1002/1099-0690(200108)2001:16<3155::AID-EJOC3155>3.0.CO;2-8
(2001)

Article Doi