A short and efficient synthesis of the C-3 to C-10 portion of the maytansinoids

DOI: 10.1016/S0040-4020(01)86450-4

Source and publish data:

Tetrahedron p. 4133 - 4142 (1991)

Update date:2022-07-30

Topics: Synthesis Efficient Experimental Chemical terms Maytansinoids

Authors:

Hodgson Hodgson

Parsons Parsons

Stones Stones

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Article abstract of DOI:10.1016/S0040-4020(01)86450-4

The cyclic carbamate (3), a key intermediate in our projected synthesis of trenudine (2), has been synthesised from 3,4-epoxycyclohexene (4) by ozonolytic cleavage of the cyclopentene (9) as a key step.

Full text of DOI:10.1016/S0040-4020(01)86450-4

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